Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1

1997 • 1,715 citations

Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis

1998 • 702 citations

Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

1998 • 663 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

Selective vulnerability in the gerbil hippocampus following transient ischemia

1984 • 562 citations

Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration

1997 • 332 citations

Global Ischemia Induces Downregulation of Glur2 mRNA and Increases AMPA Receptor-Mediated Ca²⁺Influx in Hippocampal CA1 Neurons of Gerbil

1997 • 295 citations

Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy

1999 • 290 citations

Hypoxia—ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum

1997 • 271 citations

Neurotransmitter transporters : structure, function, and regulation

2002 • 251 citations

Review Article The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype

1998 • 239 citations

Traumatic Brain Injury Down‐Regulates Glial Glutamate Transporter (GLT‐1 and GLAST) Proteins in Rat Brain

1998 • 226 citations

Mechanisms of Secondary Brain Damage in Global and Focal Ischemia: A Speculative Synthesis

1995 • 208 citations

Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus

1995 • 145 citations

The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study

1998 • 130 citations

Selective vulnerability of hippocampal CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: Brain microdialysis study

1992 • 100 citations

Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease

1999 • 96 citations

Non‐synaptic Localization of the Glutamate Transporter EAACI in Cultured Hippocampal Neurons

1997 • 93 citations

GABA Agonist "Muscimol" Is Neuroprotective in Repetitive Transient Forebrain Ischemia in Gerbils

1993 • 89 citations

Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus

1995 • 79 citations

Rapid Down‐Regulation of GABA_A Receptors in the Gerbil Hippocampus Following Transient Cerebral Ischemia

1995 • 68 citations

Zonisamide as a neuroprotective agent in an adult gerbil model of global forebrain ischemia: a histological, in vivo microdialysis and behavioral study

1997 • 67 citations

Glutamate excitotoxicity in transient global cerebral ischemia

1996 • 64 citations

The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluations

1996 • 62 citations

Rapid decline of GABA_A receptor subunit mrna expression in hippocampus following transient cerebral ischemia in the gerbil

1993 • 61 citations

Protection against post-ischemic behavioral pathology by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil

1991 • 60 citations

Expression of Two Glutamate Transporters, GLAST and EAAT4, in the Human Cerebellum: Their Correlation in Development and Neonatal Hypoxic-Ischemic Damage

1998 • 59 citations

Fimbria‐Fornix Transections Selectively Down‐Regulate Subtypes of Glutamate Transporter and Glutamate Receptor Proteins in Septum and Hippocampus

1996 • 54 citations

Differential Expressions of Glycine Transporter 1 and Three Glutamate Transporter mRNA in the Hippocampus of Gerbils with Transient Forebrain Ischemia

1999 • 43 citations

The High-Affinity Glutamate Transporter Family

1997 • 43 citations

The glycine antagonist and free radical scavenger 7-C1-thio-kynurenate reduces CA1 ischemic damage in the gerbil

1994 • 42 citations

Activation of iron handling system within the gerbil hippocampus after cerebral ischemia

1996 • 38 citations

CGS-19755 is neuroprotective during repetitive ischemia: This effect is significantly enhanced when combined with hypothermia

1993 • 36 citations

Beneficial effects of S-adenosyl-l-methionine on blood–brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils

1997 • 26 citations

Editing of GluR2 RNA in the Gerbil Hippocampus after Global Cerebral Ischemia

1996 • 24 citations

Effects of MK-801 and Pentobarbital on Cholinergic Terminal Damage and Delayed Neuronal Death in the Ischemic Gerbil Hippocampus

1997 • 20 citations

Effect of glutamate transporter on neuronal damage induced by photochemical thrombotic brain ischemia

1998 • 20 citations

Comparative neuroprotective properties of the benzodiazepine receptor full agonist diazepam and the partial agonist PNU-101017 in the gerbil forebrain ischemia model

1998 • 15 citations