Enlargement of High Density Lipoprotein in Mice via Liver X Receptor Activation Requires Apolipoprotein E and Is Abolished by Cholesteryl Ester Transfer Protein Expression

Beyond Cholesterol

1989 • 6,533 citations

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

1996 • 2,293 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

1999 • 1,708 citations

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

1996 • 1,678 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

2000 • 1,619 citations

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

1999 • 1,527 citations

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

1999 • 1,441 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

The Response-to-Retention Hypothesis of Early Atherogenesis

1995 • 1,365 citations

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

2000 • 1,285 citations

High density lipoprotein metabolism.

1984 • 1,230 citations

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

2003 • 1,075 citations

Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor

2000 • 962 citations

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway

1999 • 732 citations

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

2001 • 643 citations

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

2000 • 543 citations

Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice

2000 • 477 citations

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

1978 • 430 citations

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.

1995 • 416 citations

Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels

1999 • 378 citations

Plasma lipid transfer proteins.

1988 • 374 citations

Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

2001 • 356 citations

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

2000 • 355 citations

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

1991 • 300 citations

Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic Gluconeogenesis

2003 • 289 citations

Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis

2001 • 287 citations

Atherogenic Hyperlipoproteinemia: The Cellular and Molecular Biology of Plasma Lipoproteins Altered by Dietary Fat and Cholesterol

1982 • 281 citations

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations

2003 • 225 citations

Liver X Receptor Activators Display Anti-Inflammatory Activity in Irritant and Allergic Contact Dermatitis Models: Liver-X-Receptor-Specific Inhibition of Inflammation and Primary Cytokine Production

2003 • 224 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 222 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 204 citations

Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron 1

2001 • 199 citations

Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency.

1990 • 183 citations

Phospholipid Transfer Protein Is Regulated by Liver X Receptors in Vivo

2002 • 183 citations

Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins.

1985 • 163 citations

Apolipoprotein E and the Apolipoprotein E-Deficient Mouse

1995 • 142 citations

Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitro.

1983 • 142 citations

1999 George Lyman Duff Memorial Lecture

2000 • 135 citations

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

2002 • 123 citations

An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels.

1992 • 122 citations

Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein

1999 • 121 citations

The Lipidation by Hepatocytes of Human Apolipoprotein A-I Occurs by Both ABCA1-dependent and -independent Pathways

2003 • 86 citations

The ABCA1 transporter functions on the basolateral surface of hepatocytes

2002 • 82 citations

Identification of apolipoprotein B-100 low density lipoproteins, apolipoprotein B-48 remnants, and apolipoprotein E-rich high density lipoproteins in the mouse.

1994 • 81 citations

Transgenic mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans.

1995 • 64 citations

Beyond LDL-C – The Importance of Raising HDL-C

2002 • 48 citations

Expression of simian CETP in normolipidemic Fisher rats has a profound effect on large sized apoE-containing HDL

2002 • 20 citations