Clonal Origin of Multiple Lung Cancers

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Cancer statistics, 1995

1995 • 1,434 citations

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

1988 • 458 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors

1985 • 387 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract.

1993 • 241 citations

Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung

1992 • 188 citations

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

1993 • 180 citations

Multiple primary lung cancers. Results of surgical treatment.

1990 • 164 citations

Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions

1995 • 160 citations

Multiple primary lung cancers

1990 • 139 citations

Assessment of clonality in human tumors: a review.

1990 • 135 citations

Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression

1995 • 129 citations

Common clonal origin of synchronous primary head and neck squamous cell carcinomas: Analysis by tumor karyotypes and fluorescence in situ hybridization

1995 • 99 citations

Synchronous Primary Lung Cancers

1993 • 56 citations

Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias.

1997 • 44 citations

K-ras activation in non-small cell lung cancer in the dog

1993 • 40 citations

Altered DNA methylation patterns in human lung carcinomas.

1986 • 4 citations