Failure to withstand oxidative stress induced by phospholipid hydroperoxides as a possible cause of the lens opacities in systemic diseases and ageing

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1968 • 7,671 citations

Ciba foundation symposium

1964 • 2,217 citations

Lipid hydroperoxide measurement by oxidation of Fe²⁺ in the presence of xylenol orange. Comparison with the TBA assay and an iodometric method

1991 • 607 citations

Development of synthetic compounds with glutathione peroxidase activity

1989 • 403 citations

Oxidative stress on lens and cataract formation: role of light and oxygen

1984 • 305 citations

Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo?

1989 • 301 citations

<scp>l</scp>-carnosine (β-alanyl-<scp>l</scp>-histidine) and carcinine (β-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities

1994 • 223 citations

Molecular mechanism of cataractogenesis: III. Toxic metabolites of oxygen as initiators of lipid peroxidation and cataract

1984 • 219 citations

Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA

1992 • 211 citations

GLUTATHIONE PEROXIDASE IN LENS AND A SOURCE OF HYDROGEN PEROXIDE IN AQUEOUS HUMOUR

1965 • 187 citations

Lipid Peroxidation In Biomembranes

2018 • 177 citations

Studies on the Oxidation of Cysteine to Cystine in Lens Proteins During Cataract Formation*

1951 • 177 citations

Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins

1990 • 171 citations

Lipid peroxidation in cataract of the human

1986 • 168 citations

Cataracts in the Royal College of Surgeons rat: Evidence for initiation by lipid peroxidation products

1985 • 139 citations

Photoperoxidation in Lens and Cataract Formation: Preventive Role of Superoxide Dismutase, Catalase and Vitamin C

1982 • 132 citations

Lipid peroxidation as a possible cause of cataract

1988 • 116 citations

Human cataract formation.

1984 • 113 citations

Lipid peroxidation in biomembranes

1989 • 107 citations

Lipid peroxide and reactive oxygen species generating systems of the crystalline lens

1994 • 99 citations

Effects of lipid peroxidation products on the rat lens in organ culture: A possible mechanism of cataract initiation in retinal degenerative disease

1983 • 95 citations

Lipid peroxidation and human cataractogenesis in diabetes and severe myopia

1989 • 92 citations

Disulphide cross-linked protein of high molecular weight in human cataractous lens

1973 • 92 citations

Age-Dependent Changes in Lipid Peroxide Levels in the Lipoprotein Fractions of Human Serum

1984 • 91 citations

The Stereochemistry of the Reactions of Lipoxygenases and Their Metabolites. Proposed Nomenclature of Lipoxygenases and Related Enzymes

1986 • 90 citations

Oxidative modification of lens crystallins by H2O2 and chelated iron

1989 • 86 citations

Lipid peroxide and transition metals are required for the toxicity of oxidized low density lipoprotein to cultured endothelial cells

1991 • 83 citations

Antioxidant activity of l-carnosine, a natural histidine-containing dipeptide in crystalline lens

1989 • 76 citations

Lens opacity induced by lipid peroxidation products as a model of cataract associated with retinal disease

1989 • 75 citations

Peroxide-induced effects on lens cation transport following inhibition of glutathione reductase activity in vitro

1987 • 73 citations

Molecular mechanisms of cataractogenesis: IV. Evidence of phospholipid · malondialdehyde adduct in human senile cataract

1986 • 65 citations

Structural Characterization of Lipid Membranes from Clear and Cataractous Human Lenses

1993 • 53 citations

The alpha and gamma crystallin content in aqueous humor of eyes with clear lenses and with cataracts

1979 • 52 citations

The dual effect of oxidation on lipid bilayer structure

1992 • 51 citations

Accumulation of lipid peroxidation products in human cataracts

1989 • 49 citations

Ca²⁺-ATPase activity in the human lens

1989 • 49 citations

Source of cholesterol for the ocular lens, studied with U18666A: A cataract-producing inhibitor of lipid metabolism

1983 • 49 citations

A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases.

1984 • 49 citations

Oxidative inhibition of Ca2+-ATPase in the rabbit lens.

1989 • 48 citations

Modelling cortical cataractogenesis. XI. Vitamin C reduces γ-crystallin leakage from lenses in diabetic rats

1990 • 48 citations

Activity of glutathione peroxidase and glutathione reductase in the human lens related to age

1986 • 45 citations

The alteration of lipid peroxide in glucocorticoid-induced cataract of developing chick embryos and the effect of ascorbic acid

1986 • 45 citations

Developments in Biochemistry

1947 • 43 citations

Systemic Human Diseases as Oxidative Risk Factors in Cataractogenesis

1988 • 42 citations

Free Radical Enhancer Xenobiotic is an Inducer of Cataract in Rabbit

1991 • 41 citations

Lipoproteins and lipids in cow and human aqueous humor

1984 • 37 citations

The synthesis of cyclooxygenase products in ocular tissues of various species

1984 • 36 citations

Spectral characterization of lipid peroxidation in rabbit lens membranes induced by hydrogen peroxide in the presence of Fe2+Fe3+ cations: A site-specific catalyzed oxidation

1994 • 36 citations

Serum lipid peroxide levels in rats with inherited cataracts.

1985 • 35 citations

The effect of ascorbate, hydroperoxides, and bradykinin on prostaglandin production by corneal and lens cells.

1982 • 32 citations

Age-related changes in glutathione synthesis in the eye lens

1990 • 31 citations

Lipid fluorophores of the human crystalline lens with cataract

1989 • 31 citations

Development of fluorescence and cross-links in eye lens crystallin by interaction with lipid peroxy radicals

1991 • 27 citations

Peroxide-metabolizing systems of the crystalline lens

1992 • 26 citations

The alpha-crystallin content of aqueous humour in cortical, nuclear, and complicated cataracts

1976 • 26 citations

Distribution of phospholipid-malondialdehyde-adduct in the human lens.

1989 • 26 citations

Macrophage mediated damage to rat lenses in culture: a possible model for uveitis-associated cataract.

1983 • 25 citations

Systemic human diseases as oxidative risk factors in cataractogenesis. II. Chronic renal failure

1990 • 25 citations

A Study on Lipid Peroxide-induced Lens Damage In Vitro

1994 • 24 citations

REACTIVITY OF PHOTOCHEMICALLY‐GENERATED LIPID HYDROPEROXIDES IN CELL MEMBRANES WITH GLUTATHIONE PEROXIDASE

1989 • 21 citations

Generation of lipoxygenase products in the avascular tissues of the eye

1985 • 20 citations

Na,K-ATPase and phospholipid degradation in bovine and human lenses

1992 • 17 citations

Aldehyde Dehydrogenase, Aldose Reductase, and Free Radical Scavengers in Cataract

1991 • 16 citations

Morphometric evaluation of human lens opacification

1989 • 14 citations

Image analysis of the lens opacities induced in developing chick embryo by glucocorticoid

1992 • 13 citations

ESR spin label and ultrastructural monotoring of protein-lipid interactions in the lends fiber-cell plasma membranes in relation to human ageing and cataractogenesis

1992 • 11 citations

Comparative Studies on Fatty Acid Composition and Phospholipases A and C Activities in Rabbit and Bovine Iris-Ciliary Body

1993 • 4 citations