Molecular approaches to vertebrate limb morphogenesis

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Models of biological pattern formation

1982 • 1,851 citations

Gene Activity in Early Development

1968 • 1,725 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

A homologous protein-coding sequence in drosophila homeotic genes and its conservation in other metazoans

1984 • 920 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Diffusion in Embryogenesis

1970 • 895 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.

1984 • 776 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

A new retinoic acid receptor identified from a hepatocellular carcinoma

1988 • 613 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Retinoic acid and thyroid hormone induce gene expression through a common responsive element

1988 • 586 citations

Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific

1989 • 493 citations

Vitamin A and pattern formation in the regenerating limb

1982 • 463 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes.

1989 • 403 citations

A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1.

1989 • 399 citations

Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

1988 • 393 citations

Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis.

1989 • 373 citations

Limb Development and Regeneration

1987 • 357 citations

The molecular organization of the Antennapedia locus of drosophila

1983 • 331 citations

En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.

1987 • 330 citations

A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development

1985 • 312 citations

Cellular death in morphogenesis of the avian wing

1962 • 298 citations

Mesoderm induction and mesoderm-inducing factors in early amphibian development

1989 • 274 citations

Pattern formation. A primer in developmental biology

1985 • 256 citations

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

1989 • 251 citations

Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila

1984 • 244 citations

A Novel Thyroid Hormone Receptor Encoded by a cDNA Clone from a Human Testis Library

1987 • 242 citations

Spatial distribution of cellular protein binding to retinoic acid in the chick limb bud

1988 • 241 citations

Retinoic acid regulates growth hormone gene expression

1989 • 240 citations

Gene Activity in Early Development

1988 • 237 citations

Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox.

1988 • 219 citations

Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells

1985 • 209 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

The bithorax complex: control of segmental identity

1987 • 188 citations

Cellular retinoic acid-binding protein from rat testis. Purification and characterization

1978 • 187 citations

The localization and regulation of Antennapedia protein expression in Drosophila embryos

1986 • 186 citations

A model for chondrogenic condensations in the developing limb: the role of extracellular matrix and cell tractions

1985 • 183 citations

Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads.

1989 • 176 citations

An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation.

1988 • 176 citations

An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters

1988 • 166 citations

A description of chick wing bud development and a model of limb morphogenesis

1973 • 155 citations

Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridine.

1983 • 154 citations

Retinoic acid-induced pattern duplication in regenerating urodele limbs

1984 • 153 citations

Influence of retinoid nutritional status on cellular retinol- and cellular retinoic acid-binding protein concentrations in various rat tissues.

1985 • 145 citations

Vertebrate homeodomain proteins: families of region-specific transcription factors

1989 • 145 citations

Studies on the mechanism of retinoid-induced pattern duplications in the early chick limb bud: temporal and spatial aspects.

1985 • 139 citations

Homeotic genes and the control of segment diversity

1988 • 138 citations

Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid

1988 • 135 citations

Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

1987 • 123 citations

Positional signalling by Hensen’s node when grafted to the chick limb bud

1986 • 110 citations

Do multigene families regulate vertebrate development?

1988 • 109 citations

Characterization of concentration gradients of a morphogenetically active retinoid in the chick limb bud.

1987 • 109 citations

A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos

1988 • 105 citations

Position dependent expression of a homeobox gene transcript in relation to amphibian limb regeneration.

1988 • 94 citations

Complementary homeo protein gradients in developing limb buds.

1989 • 88 citations

Development in mammals, vol. 5

1984 • 81 citations

Characterization of retinoid metabolism in the developing chick limb bud

1988 • 79 citations

Mutational Analysis of the Chicken Progesterone Receptor

1989 • 77 citations

Expression pattern of homeobox-containing genes during chick embryogenesis

1989 • 69 citations

Morphogenetic gradients — past and present

1987 • 58 citations

Retinoic acid-binding protein in the chick limb bud: identification at developmental stages and binding affinities of various retinoids

1986 • 56 citations

Views of limb development and regeneration

1986 • 46 citations

The time required for positional signalling in the chick wing bud

1980 • 43 citations

Vitamin A and the control of pattern in developing limbs.

1983 • 42 citations

Identification of the cellular retinoic acid binding protein (cRABP) within the embryonic mouse (CD‐1) limb bud

1985 • 41 citations

Isolation of potential vertebrate limb-identity genes.

1989 • 36 citations

The mouse Hox2.3 homeobox-containing gene: regulation in differentiating pluripotent stem cells and expression pattern in embryos

1987 • 28 citations

The role of the zone of polarizing activity in controlling the differentiation of the apical mesenchyme of the chick wing-bud: histochemical thechniques in the analysis of a developmental problem

1981 • 24 citations

Experimental manipulation leading to induction of dorsal ectodermal ridges on normal limb buds results in a phenocopy of the eudiplopodia chick mutant

1986 • 19 citations

Expression of a murine homeobox gene precedes the induction of c-fos during mesodermal differentiation of P19 teratocarcinoma cells

1988 • 18 citations

The murine homeo box gene product, Hox 1.1 protein, is growth-controlled and associated with chromatin

1987 • 15 citations