Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade

The effect of sodium ions on the electrical activity of the giant axon of the squid

1949 • 3,479 citations

POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES

1943 • 2,733 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Pharmacologic Analysis of Drug Receptor Interaction

1988 • 936 citations

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

1988 • 822 citations

DRUG INTERACTIONS AT THE GABA RECEPTOR-IONOPHORE COMPLEX

1982 • 696 citations

[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.

1983 • 544 citations

Antiepileptic drugs : mechanisms of action

1980 • 508 citations

Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neurons

1989 • 507 citations

Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low‐threshold current.

1989 • 458 citations

GABA _A -Receptor Function in Hippocampal Cells Is Maintained by Phosphorylation Factors

1988 • 303 citations

Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-gaba receptor-ionophore complex

1984 • 298 citations

Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurones

1977 • 254 citations

Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons.

1985 • 242 citations

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons

1989 • 225 citations

Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons

1986 • 178 citations

Convulsant/depressant site of action at the allosteric benzodiazepine-gaba receptor-ionophore complex

1983 • 164 citations

Evidence that bicuculline and picrotoxin act at separate sites to antagonize γ-aminobutyric acid in rat cuneate nucleus

1980 • 158 citations

Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction

1990 • 145 citations

Ethosuximide in the treatment of absence (petit mal) seizures

1975 • 126 citations

Rat hippocampal neurons in culture: properties of GABA-activated Cl- ion conductance

1984 • 116 citations

Classification of some GABA antagonists with regard to site of action and potency in slices of rat cuneate nucleus

1982 • 109 citations

Dissociation of [³⁵S]t‐Butylbicyclophosphorothionate Binding Differentiates Convulsant and Depressant Drugs that Modulate GABAergic Transmission

1985 • 96 citations

Barbiturate recognition site on the GABA/benzodiazepine receptor complex is distinct from the picrotoxinin/TBPS recognition site

1984 • 80 citations

Outward rectification of inhibitory postsynaptic currents in cultured rat hippocampal neurones.

1988 • 69 citations

Pentylenetetrazol: An antagonist of gaba at primary afferents of the isolated frog spinal cord

1976 • 55 citations

Requirement of NMDA receptor/channels for intracellular high-energy phosphates and the extent of intraneuronal calcium buffering in cultured mouse hippocampal neurons

1988 • 53 citations

Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site.

1983 • 49 citations

Effects of Antiepileptic Drugs on GABA Responses and on Reduction of GABA Responses by PTZ and DMCM on Mouse Neurons in Cell Culture

1989 • 43 citations

Methsuxirnide for complex partial seizures

1983 • 42 citations

Barbiturates allosterically inhibit GABA antagonist and benzodiazepine inverse agonist binding

1984 • 39 citations

Effects of ethosuxirnide and tetramethylsuccinimide on cultured cortical neurons

1984 • 36 citations

Plasma levels of methsuximide and N‐desmethylmethsuximide during methsuximide therapy

1974 • 34 citations

Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.

1982 • 32 citations

Plasma concentrations of phensludmide, methsuximide, and their metabolites in relation to clinical efficacy

1979 • 24 citations

Structure-activity relationships of alkyl-substituted gamma-butyrolactones and succinimides.

1982 • 21 citations

Comparison of epileptogenic properties of unsubstituted and beta-alkyl-substituted gamma-butyrolactones.

1982 • 21 citations