Mechanism of pokeweed mitogen inhibition of rhIL-4-induced human IgE synthesis

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Single step separation of human T and B cells using AET treated SRBC rosettes

1976 • 337 citations

Measurement of IgE in normal and allergic serum by radioimmunoassay.

1971 • 335 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

1988 • 315 citations

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

1991 • 270 citations

Interleukin 5 enhances interleukin 4‐induced IgE production by normal human B cells. The role of soluble CD23 antigen

1988 • 265 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Abnormalities in the Regulation of Human IgE Synthesis

1978 • 242 citations

CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production.

1991 • 219 citations

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

1988 • 208 citations

Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE.

1988 • 175 citations

Subpopulations of circulating B cells and regulatory T cells involved in in vitro immunoglobulin E production in atopic patients with elevted serum immunoglobulin E.

1980 • 132 citations

Human IgE Biosynthesis in Vitro: Studies with Atopic and Normal Blood Mononuclear Cells and Subpopulations

1979 • 120 citations

Induction of human IgE synthesis by a factor derived from T cells of patients with hyper-IgE states.

1983 • 100 citations

Human IgE antibody synthesis in vitro: stimulation of IgE responses by pokeweed mitogen and selective inhibition of such responses by human suppressive factor of allergy (SFA).

1981 • 77 citations

Human IgE synthesis in vitro: a reassessment.

1981 • 70 citations

In vitro production of IgE by human peripheral blood mononuclear cells. I. Rate of IgE biosynthesis.

1980 • 67 citations

Recombinant human IL-4 induces IgE and IgG synthesis by normal and atopic donor mononuclear cells. Similar dose response, time course, requirement for T cells, and effect of pokeweed mitogen.

1990 • 66 citations

Stimulation and regulation of human IgE production in vitro using peripheral blood lymphocytes

1979 • 63 citations

In vitro production of IgE by human peripheral blood mononuclear cells. II. Cells involved in the spontaneous IgE production in atopic patients.

1980 • 63 citations

Regulation of the IgE System: Experimental and Clinical Aspects

1984 • 55 citations

IgE production in vitro by human blood mononuclear cells: a comparison between atopic and nonatopic subjects

1983 • 51 citations

In vitro stimulation of IgE production at a single precursor level by human alloreactive T helper clones.

1984 • 48 citations

In vitro synthesis of IgE by human peripheral blood leucocytes. III. Release of pre-formed antibody.

1983 • 46 citations

Lack of pokeweed mitogen-induced IgE formation in vitro by human peripheral blood mononuclear cells: detection of cross-reacting idiotypic determinants on polyclonal Ig by antibodies to a single IgE myeloma protein.

1983 • 43 citations

Disulfide assignments in recombinant mouse and human interleukin 4

1991 • 42 citations

Effect of recombinant human interleukin 4 on spontaneous in vitro human IgE synthesis^*

1988 • 41 citations

Stimulation of primary in vitro IgE antibody responses in culture of human peripheral mononuclear cells.

1981 • 38 citations

Isotype-specific human B lymphocytes that produce immunoglobulin E in vitro when stimulated by pokeweed mitogen

1980 • 28 citations

A cell culture system that enhances mononuclear cell IgE synthesis induced by recombinant human interleukin-4

1990 • 28 citations

In vitro production of IgE by lymphocytes from a patient with hyperimmunoglobulinaemia E, eosinophilia and increased lymphocytes carrying surface IgE.

1975 • 27 citations

Variability of IgE protein measurement in cell-culture supernatants: Results from a multicenter collaborative study

1986 • 26 citations

Human IgE mRNA expression by peripheral blood lymphocytes stimulated with interleukin 4 and pokeweed mitogen

1990 • 24 citations

Human IgE, IgG and IgE Antibody Synthesis <i>in vitro</i>

1980 • 23 citations

In vitro synthesis of IgE by human lymphocytes. I. The spontaneous secretion of IgE by B lymphocytes from allergic individuals: a model to investigate the regulation of human IgE synthesis.

1984 • 21 citations

Selective enhancement of human IgE production in vitro by synergy of pokeweed mitogen and mercuric chloride.

1983 • 16 citations

In vitro IgE formation by peripheral blood lymphocytes from normal individuals and patients with allergic bronchopulmonary aspergillosis.

1980 • 15 citations

IgE production in vitro by peripheral blood mononuclear cells of patients with parasitic helminth infections.

1984 • 14 citations

Workshop on measurement of in vitro IgE synthesis and regulation of IgE synthesis

1986 • 12 citations

Human IgE synthesis in vitro by pokeweed mitogen-stimulated human lymphoid cells: verification with a reconfirmed epsilon-specific radioimmunoassay.

1984 • 11 citations

Regulatory Effect of Hydrocortisone on the in vitro Synthesis of IgE by Human Lymphocytes

1985 • 8 citations

Regulation of Human IgE Synthesis

1985 • 7 citations

A Monoclonal Antibody-Based Radioimmunoassay for the in vitro Production of IgE by Lymphocyte Cultures

1985 • 6 citations

The regulatory effect of histamine on the immune response: III. Defect on in vitro IgE production in atopics.

1984 • 6 citations

Induction of IgE Synthesis in Anti-IgM-Activated Nonatopic Human B Cells by Recombinant Interleukin-3

1989 • 5 citations

In Vitro Production of IgE and IgG Protein by Blood Mononuclear Cells from Non‐Atopic and Atopic Donors

1985 • 4 citations

In vitro IgE-secretion in atopic eczema: influence of allergens and mitogens and role of CD8 T cell subpopulation.

1989 • 3 citations

The determination of IgE synthesis in vitro methodological aspects

1990 • 3 citations

Human rib bone marrow mononuclear cells spontaneously synthesize and secrete IgEin vitro

1991 • 3 citations

In vitro IgE‐secreting cells in man I. Mitogen‐independent and ‐dependent subpopulations

1985 • 2 citations

The Regulatory Effect of Macrophages on the in Vitro Synthesis of IgE

1985 • 1 citations