The respiration‐linked limiting step of tumor cell transition from the non‐cycling to the cycling state: Its inhibition by oxidizable substrates and its relationships to purine metabolism

Principles of biochemistry

1978 • 5,242 citations

Methods of enzymatic analysis

1964 • 5,230 citations

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Über die Eigenschaften eines neuen Chromogens für die Blutzuckerbestimmung nach der GOD/POD-Methode

1970 • 644 citations

Growth, Nutrition, and Metabolism of Cells in Culture

1977 • 467 citations

Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation

1963 • 418 citations

THE METABOLISM OF TUMOURS

1931 • 372 citations

The Biochemistry of the Nucleic Acids

1954 • 340 citations

The glycolysis and respiration of tumors

1961 • 285 citations

INHIBITION OF AN ELECTRON TRANSPORT COMPONENT BY ANTIMYCIN A

1952 • 271 citations

Bioenergetics and the problem of tumor growth.

1972 • 240 citations

Gluconeogenesis: Its Regulation in Mammalian Species

1977 • 209 citations

Regulation of the citric acid cycle in mammalian systems

1980 • 171 citations

The Ability of Purine and Thymine Derivatives and of Glycine to Support the Growth of Mammalian Cells in Culture

1959 • 136 citations

The cellular location of dihydroorotate dehydrogenase: Relation to de novo biosynthesis of pyrimidines

1976 • 135 citations

The Tumor Dormant State

1981 • 123 citations

Enzymatic Aspects of Folic Acid

1963 • 114 citations

Why do tumor cells have a high aerobic glycolysis?

1976 • 114 citations

Extracellular Compartments of Solid Tumors

1975 • 105 citations

Regulation of Pyruvate Dehydrogenase in Rat Liver Mitochondria by Phosphorylation-Dephosphorylation

1974 • 104 citations

Occurrence of the malate-aspartate shuttle in various tumor types.

1976 • 95 citations

Growth-Promoting Properties of Pyruvate, Oxalacetate, and -Ketoglutarate For Isolated Walker Carcinosarcoma 256 Cells

1958 • 72 citations

Nutritional requirements for growth of a mouse lymphoma in cell culture

1960 • 58 citations

The Role of Glycolysis in the Growth of Tumor Cells

1965 • 53 citations

Oxocarboxylic acids, pyridine nucleotide‐linked oxidoreductases and serum factors in regulation of cell proliferation

1979 • 48 citations

Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts

1980 • 46 citations

On the Role of Dihydroorotate Dehydrogenase in Growth Cessation of Ehrlich Ascites Tumor Cells Cultured under Oxygen Deficiency

1980 • 42 citations

Inhibition of Glycolysis by Pyruvate in Relation to the Accumulation of Citric Acid Cycle Intermediates in the Perfused Rat Heart

1964 • 37 citations

The Significance of Glycolysis<xref ref-type="fn" rid="FN2">2</xref>

1965 • 36 citations

The role of respiration in tumor cell transition from the noncycling to the cycling state

1981 • 34 citations

Reversal of adenine toxicity by pyrimidine nucleosides

1961 • 29 citations

Control of pyrimidine biosynthesis in human lymphocytes. Inhibitory effect of guanine and guanosine on induction of enzymes for pyrimidine biosynthesis de novo in phytohemagglutinin-stimulated lymphocytes.

1976 • 26 citations

Modern approaches to the study of mammalian cells in culture

1960 • 26 citations

The cell cycle 1981: One or more limit cycle oscillations?

1981 • 20 citations

On the mechanism of the glucose-induced ATP catabolism in ascites tumour cells and its reversal by pyruvate

1980 • 20 citations

Effects of pyruvate on the growth of normal and transformed hamster embryo fibroblasts

1982 • 18 citations

Regulation of Energy Metabolism in Normal and Tumor Tissues

1975 • 16 citations

Substrate modification of the Crabtree effect in Ehrlich Ascites tumor cells

1965 • 15 citations

Pyruvate inhibition of glycolysis in ehrlich ascites tumor cells

1968 • 15 citations

The role of pyruvate in the oxidation of glucose and lactate

1961 • 15 citations

Control of Pyrimidine Biosynthesis in Human Lymphocytes

1973 • 11 citations

Inhibition of Tumor cell Glycolysis by DPNH₂, and Reversal of the Inhibition by DPN, Pyruvate or Methylene blue

1963 • 8 citations

STUDIES ON THE KINETICS OF INITIAL CYCLE PROGRESSION IN VITRO OF ASCITES TUMOUR CELLS SUBSEQUENT TO ISOLATION FROM ASCITES FLUID

1980 • 8 citations

PROTEIN METABOLISM IN TUMOR CELLS AT VARIOUS STAGES OF GROWTH IN VIVO

1974 • 8 citations

[Research on the nature of the substrates of endogenous respiration of Yoshida's ascites hepatoma].

1965 • 4 citations

[ACTION OF VARIOUS INHIBITORS ON THE ENDOGENOUS RESPIRATION OF HEPATOMA ASCITES CELLS AND OF THE LIVER].

1963 • 3 citations