Emerging role of anti-tumor necrosis factor therapy in rheumatic diseases.

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

2000 • 2,992 citations

Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease

1999 • 2,656 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

2000 • 1,757 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor ? monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis

1998 • 1,642 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial

2000 • 1,463 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial

2001 • 913 citations

Still's disease in the adult.

1971 • 735 citations

Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis

1995 • 686 citations

A proinflammatory role for IL-18 in rheumatoid arthritis

1999 • 629 citations

Localization of Tumor Necrosis Factor α in Synovial Tissues and at the Cartilage–Pannus Junction in Patients With Rheumatoid Arthritis

1991 • 585 citations

Infliximab for the treatment of fistulas in patients with Crohn's disease

1999 • 529 citations

Successful treatment of active ankylosing spondylitis with the anti–tumor necrosis factor α monoclonal antibody infliximab

2000 • 492 citations

Elevated tumour necrosis factor-alpha (TNF-α) biological activity in psoriatic skin lesions

1994 • 481 citations

The Majority of Epidermal T Cells in Psoriasis Vulgaris Lesions can Produce Type 1 Cytokines, Interferon-γ, Interleukin-2, and Tumor Necrosis Factor-α, Defining TC1 (Cytotoxic T Lymphocyte) and TH1 Effector Populations:1 a Type 1 Differentiation Bias is also Measured in Circulating Blood T Cells in Psoriatic Patients

1999 • 479 citations

The Cytokine Network in Lesional and Lesion-Free Psoriatic Skin Is Characterized by a T-Helper Type 1 Cell-Mediated Response

1993 • 464 citations

Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. A department of veterans affairs cooperative study

1996 • 449 citations

Thalidomide: current and potential clinical applications

2000 • 328 citations

Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study

2000 • 298 citations

Patterns of cytokine production in psoriatic synovium.

1998 • 293 citations

Randomized, Double‐Blind, Placebo Controlled Trial of Low‐Dose Pulse Methotrexate in Psoriatic Arthritis

1984 • 292 citations

Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behçet's disease. A comparative study with familial Mediterranean fever and healthy subjects.

1993 • 283 citations

Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease

2001 • 267 citations

Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis.

1994 • 237 citations

Macrophage‐derived cytokine and nuclear factor κB p65 expression in synovial membrane and skin of patients with psoriatic arthritis

2000 • 214 citations

RADIOLOGIC DIAGNOSIS AND PATHOLOGY OF THE SPONDYLOARTHROPATHIES

1998 • 202 citations

Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Bechçet's disease; soluble TNFR-75 as a biological marker of disease activity.

1997 • 174 citations

Correlated increases of tumour necrosis factor-alpha, interleukin-6 and granulocyte monocyte-colony stimulating factor levels in suction blister fluids and sera of psoriatic patients relationships with disease severity

1994 • 165 citations

Serum TNF-alpha levels correlate with disease severity and are reduced by effective therapy in plaque-type psoriasis.

1997 • 150 citations

Treatment of intestinal Behcet's syndrome with chimeric tumour necrosis factor alpha antibody

2001 • 148 citations

Treatment of Behçet's disease—An update

2001 • 147 citations

The sacroiliac joint in the spondyloarthropathies

1996 • 145 citations

Efficacy of infliximab in refractory ankylosing spondylitis: results of a six-month open-label study

2002 • 142 citations

Corticosteroid sparing effect of low dose methotrexate treatment in adult Still's disease.

1999 • 135 citations

Cytokine production in culture by cells isolated from the synovial membrane

1989 • 135 citations

Cytokines in Behçet's disease.

1996 • 133 citations

Serum ferritin and isoferritins are tools for diagnosis of active adult Still's disease.

1994 • 131 citations

Successful treatment of a small cohort of patients with adult onset of Still's disease with infliximab: first experiences

2001 • 126 citations

Course of gut inflammation in spondylarthropathies and therapeutic consequences

1996 • 103 citations

Infliximab in the treatment of adult Still's disease refractory to conventional therapy.

2001 • 101 citations

Tumor necrosis factor

1991 • 95 citations

Tumor necrosis factor-α expression in muscles of polymyositis and dermatomyositis

2000 • 90 citations

Amyloidosis induced, end stage renal disease in patients with familial Mediterranean fever is highly associated with point mutations in the MEFV gene

2001 • 85 citations

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

2001 • 68 citations

Correlation between plasma TNF-alpha, IGF-1, biochemical markers of bone metabolism, markers of inflammation/disease activity, and clinical manifestations in ankylosing spondylitis.

2000 • 66 citations

Update on therapy for refractory dermatomyositis and polymyositis

1996 • 62 citations

Suppression of fever and the acute-phase response in a patient with juvenile chronic arthritis treated with monoclonal antibody to tumour necrosis factor-alpha (cA2)

1997 • 61 citations

A preliminary study of etanercept in the treatment of severe, resistant psoriatic arthritis.

2001 • 50 citations

Expression of tumor necrosis factor-α in muscles of polymyositis

1997 • 47 citations

Short term effects of corticosteroid pulse treatment on disease activity and the wellbeing of patients with active rheumatoid arthritis

2001 • 45 citations

THU0237 Enbrel® (etanercept) in patients with psoriatic arthritis and psoriasis

2001 • 21 citations

Levels of interleukin‐18 and its binding inhibitors in the blood circulation of patients with adult‐onset Still's disease

2001 • 17 citations

Adult onset still's disease: Clinical features and course

1992 • 14 citations

Cytokine Production in Culture by Cells Isolated from the Synovial Membrane

1989 • 14 citations

Therapeutic advances in ankylosing spondylitis

2001 • 10 citations

NSAID-induced gastrointestinal toxicity.

1995 • 8 citations

Psoriatic arthritis.

1995 • 1 citations