The Alveolar Macrophage and its Role in Toxicology

Microfilaments in Cellular and Developmental Processes

1971 • 1,563 citations

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

1968 • 1,492 citations

Pulmonary Alveolar Proteinosis

1958 • 1,133 citations

The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells.

1972 • 1,102 citations

AN EXAMINATION OF THE CYTOTOXIC EFFECTS OF SILICA ON MACROPHAGES

1966 • 868 citations

Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System

1968 • 840 citations

Studies on Pulmonary Alveolar Macrophages from the Normal Rabbit: A Technique to Procure Them in a High State of Purity

1961 • 726 citations

Air Pollution and Human Health

2013 • 516 citations

METABOLIC PATTERNS IN THREE TYPES OF PHAGOCYTIZING CELLS

1963 • 500 citations

Pulmonary Emphysema and Alpha₁‐Antitrypsin Deficiency

1964 • 465 citations

TRANSFORMATION OF MONOCYTES IN TISSUE CULTURE INTO MACROPHAGES, EPITHELIOID CELLS, AND MULTINUCLEATED GIANT CELLS

1966 • 449 citations

THE PARTICULATE HYDROLASES OF MACROPHAGES

1963 • 422 citations

ANTIBODY FORMATION INITIATED IN VITRO

1963 • 360 citations

Hypersensitivity diseases of the lungs due to fungi and organic dusts

1971 • 324 citations

Physico-Chemical Properties of Silica in Relation to its Toxicity

1966 • 324 citations

Diffuse fibrosing alveolitis (diffuse interstitial fibrosis of the lungs): Correlation of histology at biopsy with prognosis

1967 • 317 citations

Air Pollution and Human Health

1970 • 317 citations

CELLS AND TISSUES IN CULTURE

1966 • 312 citations

In Vivo incorporation of choline‐³H, leucine‐³H and galactose‐³H in alveolar type II pneumocytes in relation to surfactant synthesis. A quantitative radioautographic study in mouse by electron microscopy

1972 • 302 citations

The cellular origin of pulmonary surfactant.

1971 • 279 citations

Antimicrobial Agents and Chemotherapy

1966 • 273 citations

THE PARTICULATE HYDROLASES OF MACROPHAGES

1963 • 273 citations

ALLERGIC REACTIONS OF THE LUNGS TO ENZYMES OF BACILLUS SUBTILIS

1969 • 258 citations

Histopathology of Irradiation from External and Internal Sources

1949 • 256 citations

Lipoperoxidation of Lung Lipids in Rats Exposed to Nitrogen Dioxide

1968 • 251 citations

DRUGS IN HOSPITAL.

1965 • 247 citations

Human alveolar macrophages: comparison of phagocytic ability, glucose utilization, and ultrastructure in smokers and nonsmokers

1970 • 241 citations

Pulmonary Deposition and Retention of Inhaled Aerosols

1964 • 228 citations

THE IN VITRO DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES

1965 • 227 citations

THE ULTRASTRUCTURAL BASIS OF ALVEOLAR-CAPILLARY MEMBRANE PERMEABILITY TO PEROXIDASE USED AS A TRACER

1968 • 227 citations

Selective Effects of Anti-Macrophage Serum, Silica and Anti-Lymphocyte Serum on Pathogenesis of Herpes Virus Infection of Young Adult Mice

1970 • 211 citations

A hypothesis for pulmonary clearance and its implications.

1968 • 211 citations

Relation of Smoking and Age to Emphysema

1972 • 201 citations

FOCAL DEGRADATION AS A BIOLOGICAL PROCESS.

1964 • 193 citations

The Depressant Effect of Cigarette Smoke on the in Vitro Antibacterial Activity of Alveolar Macrophages

1967 • 188 citations

Cytochalasin B reversibly inhibits phagocytosis: functional, metabolic, and ultrastructural effects in human blood leukocytes and rabbit alveolar macrophages.

1971 • 187 citations

HEMATOPOIETIC ORIGIN OF MACROPHAGES AS STUDIED BY CHROMOSOME MARKERS IN MICE

1968 • 185 citations

Ozone Toxicology

1965 • 181 citations

Electron Microscopic Study of the Phagocytosis Process in Lung

1960 • 172 citations

GLYCOPROTEINS IN MEMBRANES

1968 • 165 citations

Ozone and Lipid Peroxidation

1969 • 164 citations

The Cell Periphery

1969 • 160 citations

DEPRESSION OF PHAGOCYTOSIS BY SOLUTES IN CONCENTRATIONS FOUND IN THE KIDNEY AND URINE*

1962 • 158 citations

Macrophages and immunity

1969 • 157 citations

THE IN VITRO DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES

1966 • 156 citations

CUTANEOUS HYPERSENSITIVITY DUE TO BERYLLIUM

1951 • 155 citations

Influence of Ozone on Pulmonary Cells

1968 • 152 citations

BACTERIOLOGY OF LOWER-RESPIRATORYTRACT SECRETIONS, SPUTUM, AND UPPER-RESPIRATORY-TRACT SECRETIONS IN " NORMALS " AND CHRONIC BRONCHITICS

1959 • 151 citations

A Possible Experimental Approach to the Association of Hereditary 1-Antitrypsin Deficiency and Pulmonary Emphysema.

1966 • 146 citations

THE ORIGIN OF ALVEOLAR MACROPHAGES IN MOUSE RADIATION CHIMERAS

1972 • 145 citations

A HISTOCHEMICAL STUDY OF PHAGOCYTIC AND ENZYMATIC FUNCTIONS OF RABBIT MONONUCLEAR AND POLYMORPHONUCLEAR EXUDATE CELLS AND ALVEOLAR MACROPHAGES

1963 • 145 citations

24-Hour Rhythms at Several Levels of Integration in Mice on Different Lighting Regimens.

1958 • 140 citations

Low Yield of Pulmonary Surfactant in Cigarette Smokers

1972 • 135 citations

Mixed hematopoietic and pulmonary origin of 'alveolar macrophages' as demonstrated by chromosome markers.

1966 • 135 citations

The origin of the mononuclear cells in inflammatory exudates induced by fibrinogen

1965 • 128 citations

Embryonic Origin of the Mouse Macrophage

1972 • 124 citations

Recovery of free cells from rat lungs by repeated washings.

1968 • 121 citations

The Ultrastructure of Mouse Lung: The Alveolar Macrophage

1958 • 114 citations

The Intravascular Lifespan of Monocytes

1966 • 114 citations

Effect of Ozone on Lipid Peroxidation in the Red Blood Cell.

1967 • 114 citations

The pathological anatomy of simple pneumokoniosis in coal workers

1953 • 113 citations

EFFECTS OF X-RAY ON LYMPHOID AND HEMOPOIETIC TISSUES OF ALBINO MICE

1948 • 110 citations

ROLE OF INTERFERON IN RECOVERY FROM VIRUS INFECTIONS

1960 • 107 citations

Asbestos Air Pollution

1972 • 106 citations

IDENTIFICATION OF PERITONEAL MACROPHAGES IN MOUSE RADIATION CHIMERAS

1963 • 105 citations

Alveolar lipo‐proteinosis: An ultrastructural comparison of the experimental and human forms

1972 • 103 citations

Lysosomes and the Toxicity of Particulate Pollutants

1971 • 103 citations

Experimental Study of Hypersecretion of Mucus in the Bronchial Tree

1963 • 100 citations

Structure and development of the asbestos body.

1969 • 99 citations

The effect of neuraminidase on the phagocytic process in human monocytes.

1966 • 98 citations

The ultrastructure of alveolar macrophages from human cigarette smokers and nonsmokers.

1971 • 96 citations

Pulmonary alveolar proteinosis.

1967 • 95 citations

Alveolar macrophages. Structural and functional differences between nonsmokers and smokers of marijuana and tobacco.

1971 • 95 citations

A pathway to pulmonary fibrosis: an ultrastructural study of mouse and rat following radiation to the whole body and hemithorax.

1970 • 93 citations

The pulmonary interstitial cell as immediate precursor of the alveolar macrophage.

1972 • 91 citations

Modification of human red cells by virus action; the receptor gradient for virus action in human red cells.

1946 • 90 citations

Airborne Carcinogens and Allied Compounds

1967 • 90 citations

Spore concentrations in the air of farm buildings

1964 • 88 citations

PATHOLOGIC ANATOMY OF THE LUNGS FOLLOWING SHOCK AND TRAUMA

1968 • 82 citations

The influence of bacterial species on pulmonary resistance to infection in mice subjected to hypoxia, cold stress, and ethanolic intoxication.

1965 • 82 citations

THE SPECIFICITY OF THE CYTOTOXIC ACTION OF SILICA--A STUDY IN VITRO.

1963 • 81 citations

THE FIBROGENIC ACHON OF SILICA

1969 • 78 citations

The pathogenesis of experimental pulmonary aspergillosis. An ultrastructural study of alveolar macrophages after phagocytosis of a flavus spores in vivo.

1971 • 77 citations

Effect of Atmospheric Pollutants on Susceptibility to Respiratory Infection I. Effect of Ozone

1961 • 75 citations

Induction of Experimental Emphysema^1,2

1972 • 74 citations

Effect of alcohol on the mobilization of alveolar macrophages.

1968 • 74 citations

Daily Periodicity of Susceptibility of Mice to Pneumococcal Infection

1969 • 71 citations

The biochemical activities of rabbit alveolar macrophages during phagocytosis

1965 • 70 citations

The mammalian respiratory tract surface. A scanning electron microscopic study.

1972 • 70 citations

The Fate of Inhaled Particles in the Early Postexposure Period

1960 • 69 citations

The regional deposition of inhaled aerosols in man.

1970 • 69 citations

Covert Reduction in Ventilatory Surface in Rats During Prolonged Exposure to Subacute Nitrogen Dioxide^1,2

1972 • 66 citations

Pulmonary alveolar proteinosis. A study using enzyme histochemistry, electron microscopy, and surface tension measurement.

1966 • 66 citations

Cigarette Smoke: Protection of Alveolar Macrophages by Glutathione and Cysteine

1968 • 65 citations

Pulmonary alveolar macrophage. Oxidative metabolism of isolated cells and mitochondria and effect of cadmium ion on electron- and energy-transfer reactions

1971 • 64 citations

Lysosomal Stability during Phagocytosis of Aspergillus flavus Spores by Alveolar Macrophages of Cortisone-Treated Mice

1968 • 64 citations

Origin of the lung macrophage. Evidence derived from radiation injury.

1969 • 63 citations

Pathogenesis of the nitrogen dioxide-induced lesion in the rat lung: a review and presentation of new observations.

1968 • 62 citations

Responses of Alveolar Macrophages to Metals

1972 • 62 citations

A quantitative study of bronchial mucous gland volume, emphysema and smoking in a necropsy population

1971 • 61 citations

Identification of Cells Labeled with Tritiated Thymidine in the Pulmonary Alveolar Walls of the Mouse^1,2,3

1969 • 61 citations

Synthesis of Dipalmitoyl Lecithin by Alveolar Macrophages

1972 • 60 citations

The Origin of Pulmonary Alveolar Macrophages

1971 • 60 citations

Ozone and the Antibacterial Defense Mechanisms of the Murine Lung

1971 • 57 citations

Diseases Due to Immunologic Reactions in the Lungs

1972 • 56 citations

Some biochemical effects of asbestos on macrophages.

1972 • 56 citations

Effect of Bacillus Calmette-Guérin on the Levels of Acid Phosphatase, Lysozyme and Cathepsin in Rabbit Alveolar Macrophages

1965 • 56 citations

Nitrogen Dioxide Effects on Alveolar Macrophages

1972 • 56 citations

INFLUENCE OF IRRADIATION ON RESISTANCE TO INFECTION

1960 • 56 citations

ELECTRON‐MICROSCOPE STUDIES OF ASBESTOSIS IN MAN AND ANIMALS

1965 • 55 citations

Asbestos Contamination of Parenteral Drugs

1972 • 54 citations

Immunological aspects of silicosis.

1963 • 53 citations

Nitrogen Dioxide Inhibition of Viral-Induced Resistance in Alveolar Monocytes

1970 • 53 citations

The effects of increased particles on the number of alveolar macrophages.

1970 • 52 citations

Elastase-Like, Esteroprotease Activity in Human and Rabbit Alveolar Macrophage Granules

1971 • 52 citations

Atypical Reaction to Inhaled Silica

1967 • 51 citations

Hyperplasia of Type 2 Pneumocytes and Nitrogen Dioxide (10 ppm) Exposure

1971 • 51 citations

Diseases Due to Immunologic Reactions in the Lungs

1972 • 51 citations

The surface complexes of the lung. A cytochemical partition of phospholipid surfactant and mucopolysaccharide.

1970 • 50 citations

Effect of ozone on acid hydrolases of the pulmonary alveolar macrophage.

1970 • 50 citations

Pathophysiology of Hereditary Emphysema

1971 • 46 citations

Alveolar Macrophages: Reduced Number in Rats after Prolonged Inhalation of Lead Sesquioxide

1968 • 44 citations

Ultrastructural Alterations of Alveolar Tissue of Mice

1967 • 43 citations

THE DISTRIBUTION OF INTRAVENOUSLY INJECTED PERITONEAL MACROPHAGES IN THE MOUSE

1965 • 43 citations

Studies on the Cytotoxic Action of Silica Dusts on Macrophages in Vitro

1968 • 43 citations

The intracellular site of surfactant synthesis

1973 • 42 citations

Enzymatic changes in fluorescent alveolar macrophages of the lungs of cigarette smokers.

1968 • 42 citations

Synergistic effects of aerosols

1955 • 42 citations

Interference of Cadmium Ion With Oxidative Metabolism of Alveolar Macrophages

1971 • 42 citations

Ozone Effect on Lysosomal Hydrolases of Alveolar Macrophages in Vitro

1971 • 41 citations

Patterns of bacterial clearance in murine influenza.

1965 • 41 citations

THE ULTRASTRUCTURAL CHANGES THAT OCCUR DURING THE TRANSFORMATION OF LUNG MACROPHAGES TO GIANT CELLS AND FIBROBLASTS IN EXPERIMENTAL ASBESTOSIS.

1963 • 40 citations

Rabbit Alveolar Macrophage Damage Caused by in Vivo Ozone Inhalation

1970 • 40 citations

Cigarette smoking, asbestos, and pulmonary fibrosis.

1971 • 40 citations

The pathogenesis of coal miner's pneumoconiosis

1964 • 39 citations

The Distribution of Inhaled Plutonium-239 Dioxide Particles Within Pulmonary Macrophages

1969 • 39 citations

THE RESPONSE OF THE HISTIOCYTES AND MACROPHAGES IN THE LUNGS OF RABBITS INJECTED WITH FREUND'S ADJUVANT.

1964 • 39 citations

The “Emphysema Profile” in Two Midwestern Cities in North America

1969 • 38 citations

Alveolar Reactivity Following Inhalation of Particles

1964 • 37 citations

The Pulmonary Macrophage Response to Irritants

1969 • 37 citations

Structure of rat lung after protracted oxygen breathing.

1967 • 36 citations

Transfer of Interferon-Producing Macrophages: New Approach to Viral Chemotherapy

1970 • 36 citations

The effect of acute renal failure on the bacterial clearance mechanisms of the lung.

1966 • 34 citations

Plutonium Inhalation Studies-VI Pathologic Effects of Inhaled Plutonium Particles in Dogs

1964 • 32 citations

MACROPHAGE PLASMA MEMBRANE

1971 • 32 citations

Effect of cadmium ion on respiration and ATPase activity of the pulmonary alveolar macrophage: A model for the study of environmental interference with pulmonary cell function

1970 • 32 citations

Leçons sur la pathologie comparée de l'inflammation : faites à l'Institut Pasteur en Avril et Mai 1891

1892 • 31 citations

Mononuclear Phagocytes

2016 • 31 citations

The J. Burns Amberson LECTURE The induction and expression of cell-mediated hypersensitivity in the lung.

1971 • 31 citations

Alteration of the Pathogenicity ofPasteurella pneumotropicafor the Murine Lung Caused by Changes in Pulmonary Antibacterial Activity

1967 • 30 citations

Effects of bacteria and viruses on ciliated epithelium. A study of the mechanisms of pulmonary resistance to infection: the relationship of bacterial clearance to ciliary and alveolar macrophage function.

1966 • 30 citations

The Effect of Silicosis on the Antibacterial Defense Mechanisms of the Murine Lung

1969 • 29 citations

Effects of exposure to ozone on defensive mechanisms of the lung.

1971 • 29 citations

AN IN SITU METHOD FOR HARVESTING GUINEA PIG ALVEOLAR MACROPHAGES.

1964 • 29 citations

PULMONARY ANTHRACOSIS —A COMMUNITY DISEASE

1914 • 29 citations

An Inhibitor in Human Lung Macrophages Active Against Human Neutrophil Elastase¹

1972 • 28 citations

Pulmonary Macrophage Clearance

1968 • 28 citations

Loss of Protective Factor for Alveolar Macrophages When Exposed to Ozone

1971 • 28 citations

Synergistic effects of aerosols. II. Effects on rate of clearance from the lung.

1959 • 28 citations

Fluorescent histiocytes in sputum related to smoking.

1960 • 27 citations

THE RETICULOENDOTHELIAL SYSTEM, CORTISONE, AND THYROID FUNCTION: THEIR RELATION TO NATIVE RESISTANCE TO INFECTION*

1960 • 27 citations

Cellular response to Freund's adjuvant in the rabbit lung. An electron microscope study.

1966 • 27 citations

Experimental Studies on Deposition of Inhaled Aerosols

1964 • 26 citations

The effects of chrysotile asbestos dust on lung macrophages maintained in organ culture. An electron-microscope study.

1967 • 26 citations

An autoradiographic study of the effect of neuraminidase or trypsin on transfused lymphocytes.

1969 • 26 citations

Ultrastructural Alterations of Alveolar Tissue of Mice

1966 • 24 citations

The application of the diffusion‐chamber technique to the study of silicosis

1958 • 23 citations

Experimental infective pneumoconiosis. IV. Massive pulmonary fibrosis produced by coal-mine dust and isoniazid-resistant tubercle bacilli of low virulence.

1955 • 23 citations

A concept of dust disposal in the lungs

1955 • 23 citations

The Pathology of Pneumoconiosis

1949 • 22 citations

The Effect of Whole-Body X Irradiation on the Bactericidal Activity of Phagocytic Cells II. Survival of Pseudomonas Aeruginosa within Livers and Spleens of Mice

1959 • 22 citations

Pulmonary alveolar macrophage: Demonstration of Na+ - K+, Mg++ ATPase activity

1969 • 21 citations

INFLUENCE OF IRRADIATION ON RESISTANCE TO INFECTION

1960 • 21 citations

THE DISTRIBUTION AND BEHAVIOUR OF INTRAVENOUSLY INJECTED PULMONARY ALVEOLAR MACROPHAGES IN THE MOUSE

1966 • 21 citations

The Effect of Cortisone on Experimental Silicosis

1952 • 19 citations

Desquamative interstitial pneumonia-like syndrome in rabbits. Produced experimentally by Freund's adjuvant.

1967 • 19 citations

Fine Structure of Alveolar Areas in the Lung Following Inhalation of²³⁹PuO₂Particles

1971 • 18 citations

Experimental infective Pneumoconiosis

1958 • 18 citations

Storage and Excretion of Lead 210 in Dogs

1962 • 18 citations

Pulmonary Involvement in Hypovolemic Shock

1972 • 18 citations

Tumours in Mice after Pulmonary Deposition of Radioactive Particles

1960 • 18 citations

Pulmonary Alveolar Macrophage

1971 • 16 citations

The phenomenon of macrophage congregation in vitro and its relationship to in vivo NO2 exposure of guinea pigs.

1968 • 16 citations

Toxic effects of mixtures of sulphur dioxide and smoke with air

1957 • 16 citations

Observations on the mechanism of silicotic fibrogenesis.

1970 • 16 citations

The phenomenon of respiratory failure in shock: The genesis of “shock lung”

1972 • 15 citations

Severe pulmonary emphysema. A comparison of patients with and without 1 -antitrypsin deficiency.

1972 • 15 citations

Die Phagocytoseaktivität von permanenten Fibroblasten (Monocyten), Rattenalveolarmakrophagen und menschlichen Entzündungsmakrophagen unter der Wirkung von Glucocorticoiden

1967 • 15 citations

Tuberculosis in anthracosilicosis.

1952 • 15 citations

Long-term storage, migration and elimination of dust in the lungs of animals, with special respect to the influence of polyvinyl-pyridine-N-oxide.

1970 • 15 citations

Solubility Theory of Silicosis. A Critical Study.

1947 • 14 citations

Alterations in the bactericidal ability of rabbit alveolar macrophages as a result of tumbling stress.

1973 • 14 citations

Pulmonary antibacterial mechanisms and the pathogenesis of pulmonary disease.

1968 • 12 citations

CILIARY ACTIVITY AND HISTOLOGIC OBSERVATIONS IN THE TRACHEA AFTER EXPOSURE TO AMMONIA AND CARBON PARTICLES

1967 • 11 citations

Toxicology: The Respiratory Tract

1971 • 11 citations

A study of macrophage--pulmonary vascular bed interactions in malaria-infected hamsters.

1969 • 11 citations

EFFECT OF HOSPITAL BOARD GOVERNANCE PRACTICES ON PATIENT SAFETY OUTCOME

2021 • 10 citations

The Effect of Oxygen Toxicity on the Inactivation of Bacteria by the Lung

1972 • 10 citations

Distribution and Excretion of Polonium-210. VI. After Intratracheal Administration in the Rat

1964 • 9 citations

Alkylating anticancer agents and phagocytosis. II. Effects of alkylating agents on numerical distribution and histochemistry of reticuloendothelial cells.

1972 • 9 citations

Pneumoconiosis, Silicosis, and the Physics and Chemistry of Dust

1957 • 9 citations

RESPIRATORY SEQUELS TO NON-THORACIC INJURY

1972 • 9 citations

Influence of nitrogen dioxide on the uptake of parainfluenza-3 virus by alveolar macrophages.

1972 • 9 citations

The effects of air contamination on health. I.

1967 • 9 citations

Upper Respiratory Tract Clearance in Rats after Thoracic Irradiation

1969 • 9 citations

Histochemische Untersuchungen zur Wirkung von Chlorochindiphosphat

1961 • 8 citations

Toxic Factors in Enzymes Used in Laundry Products

1971 • 8 citations

Effect of sulphur dioxide on the enzyme activity of the alveolar macrophage of rats

1970 • 8 citations

The Anthracotic Pneumoconioses

1971 • 7 citations

Dehydration and Recovery of Free Alveolar Macrophages

1971 • 7 citations

Distribution and Excretion of Polonium-210. XI. Autoradiographic Studies after Intratracheal Administration in the Rabbit

1964 • 7 citations

The effects of duration and intermittency of exposure on the elimination of air-borne dust from high and low rank coal mines.

1970 • 7 citations

Pathophysiology of the alveolar macrophage system.

1967 • 6 citations

Properties and behavior of air contaminants.

1950 • 5 citations

Detergents: Side Effects of the Washday Miracles

1970 • 5 citations

THE PATHOLOGY OF PNEUMONOCONIOSIS

1934 • 5 citations

The role of alveolar macrophages in inhalation infection of rabbits with vaccinia virus. II. Experiments with medium and small doses of virus.

1969 • 4 citations

Sialomucin and pulmonary cell injury. Ultrastructural and cytochemical studies in mice exposed to oxygen.

1971 • 3 citations

Occupational lung diseases and inferential relationships to general population hazards.

1971 • 2 citations

BRONCHITIS AND DISABILITY

1971 • 2 citations

Effect of poly-2-vinylpyridine-1-oxide on hemolysis by water

1971 • 2 citations

Effects of Photochemical Smog on Alveolar Lung Tissues of Young and Old Mice — An Electron Microscope Study

1967 • 1 citations