Origin and Evolution of Human microRNAs From Transposable Elements

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

MicroRNAs

2004 • 33,206 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

The functions of animal microRNAs

2004 • 10,392 citations

The Human Genome Browser at UCSC

2002 • 9,920 citations

<tt>BLAT</tt>—The <tt>BLAST</tt>-Like Alignment Tool

2002 • 8,153 citations

Exaptation—a Missing Term in the Science of Form

1982 • 4,836 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

miRBase: microRNA sequences, targets and gene nomenclature

2005 • 4,598 citations

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

2005 • 3,888 citations

A gene atlas of the mouse and human protein-encoding transcriptomes

2004 • 3,443 citations

Non-coding RNAs and cancer: microRNAs and beyond

2011 • 3,324 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

MicroRNA targets in Drosophila

2003 • 3,228 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

Repbase Update, a database of eukaryotic repetitive elements

2005 • 3,073 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila

2007 • 2,410 citations

The UCSC Table Browser data retrieval tool

2003 • 2,324 citations

Non-coding RNA

2006 • 2,274 citations

Fast folding and comparison of RNA secondary structures

1994 • 2,262 citations

Selfish DNA: the ultimate parasite

1980 • 2,095 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

A uniform system for microRNA annotation

2003 • 1,841 citations

Identification of hundreds of conserved and nonconserved human microRNAs

2005 • 1,825 citations

Selfish genes, the phenotype paradigm and genome evolution

1980 • 1,779 citations

Genesis: cluster analysis of microarray data

2002 • 1,737 citations

The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

2005 • 1,482 citations

Aligning Multiple Genomic Sequences With the Threaded Blockset Aligner

2004 • 1,473 citations

RNA polymerase III transcribes human microRNAs

2006 • 1,359 citations

Role of transposable elements in heterochromatin and epigenetic control

2004 • 1,198 citations

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

2005 • 1,079 citations

The origins of genome architecture

2007 • 1,030 citations

An RNA gene expressed during cortical development evolved rapidly in humans

2006 • 978 citations

The colorectal microRNAome

2006 • 934 citations

Evolution's cauldron: Duplication, deletion, and rearrangement in the mouse and human genomes

2003 • 874 citations

Fast and reliable prediction of noncoding RNAs

2005 • 667 citations

Cell-type-specific signatures of microRNAs on target mRNA expression

2006 • 650 citations

Origin of a substantial fraction of human regulatory sequences from transposable elements

2003 • 575 citations

PERSPECTIVE: TRANSPOSABLE ELEMENTS, PARASITIC DNA, AND GENOME EVOLUTION

2001 • 566 citations

MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues

2004 • 557 citations

A distal enhancer and an ultraconserved exon are derived from a novel retroposon

2006 • 489 citations

Identification and Classification of Conserved RNA Secondary Structures in the Human Genome

2006 • 486 citations

Forces Shaping the Fastest Evolving Regions in the Human Genome

2006 • 481 citations

Accelerated Evolution of Conserved Noncoding Sequences in Humans

2006 • 470 citations

Approaches to microRNA discovery

2006 • 463 citations

GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies

2004 • 458 citations

Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions

2003 • 440 citations

Turning junk into gold: domestication of transposable elements and the creation of new genes in eukaryotes

2006 • 397 citations

Mammalian microRNAs derived from genomic repeats

2005 • 296 citations

Transgene silencing by the host genome defense: implications for the evolution of epigenetic control mechanisms in plants and vertebrates.

2000 • 286 citations

A Family of Human MicroRNA Genes from Miniature Inverted-Repeat Transposable Elements

2007 • 285 citations

DNA sequence insertion and evolutionary variation in gene regulation.

1996 • 251 citations

Functional noncoding sequences derived from SINEs in the mammalian genome

2006 • 227 citations

Human microRNA prediction through a probabilistic co-learning model of sequence and structure

2005 • 219 citations

Heritable transposon silencing initiated by a naturally occurring transposon inverted duplication

2005 • 177 citations

Thousands of corresponding human and mouse genomic regions unalignable in primary sequence contain common RNA structure

2006 • 165 citations

Alu elements within human mRNAs are probable microRNA targets

2006 • 155 citations

Short RNAs Can Identify New Candidate Transposable Element Families in Arabidopsis

2002 • 138 citations

RNAi protects the Caenorhabditis elegans germline against transposition

2004 • 103 citations

Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements.

2003 • 102 citations

Transposable elements donate lineage-specific regulatory sequences to host genomes

2005 • 100 citations

A large family of ancient repeat elements in the human genome is under strong selection

2006 • 96 citations

P-element homologous sequences are tandemly repeated in the genome of Drosophila guanche.

1992 • 93 citations

Mutationism and the dual causation of evolutionary change

2006 • 86 citations

Computational evidence for hundreds of non-conserved plant microRNAs

2005 • 85 citations

A family of conserved noncoding elements derived from an ancient transposable element

2006 • 69 citations

Conserved fragments of transposable elements in intergenic regions: evidence for widespread recruitment of MIR- and L2-derived sequences within the mouse and human genomes

2003 • 63 citations

Bioinformatic discovery of microRNA precursors from human ESTs and introns

2006 • 59 citations

Host defenses to transposable elements and the evolution of genomic imprinting

2005 • 55 citations

3'UTR-located ALU elements: donors of potential miRNA target sites and mediators of network miRNA-based regulatory interactions.

2007 • 37 citations

Transposable element derived DNaseI-hypersensitive sites in the human genome.

2006 • 35 citations

Detecting MicroRNA Targets by Linking Sequence, MicroRNA and Gene Expression Data

2006 • 31 citations