Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

1987 • 806 citations

A new method for staining nerve fibers and nerve endings in mounted paraffin sections

1936 • 790 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

über eigenartige Krankheitsfälle des späteren Alters

1911 • 673 citations

Plaques, tangles and dementia

1982 • 603 citations

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

1987 • 469 citations

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

1986 • 419 citations

Silver staining of Alzheimer's neurofibrillary changes by means of physical development.

1971 • 402 citations

Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea

1982 • 398 citations

The car☐yl third of tau is tightly bound to paired helical filaments

1988 • 342 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining

1988 • 280 citations

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

1983 • 252 citations

A specific histochemical marker (lectinRicinus communis agglutinin-1) for normal human microglia, and application to routine histopathology

1986 • 208 citations

Oligodendroglial Microtubular Tangles in Olivopontocerebellar Atrophy

1990 • 181 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain.

1989 • 140 citations

Senile dementia of Alzheimer type: Astroglial reaction to extracellular neurofibrillary tangles in the hippocampus

1982 • 126 citations

THE IMMUNOHISTOCHEMICAL DEMONSTRATION OF SUBSEQUENCES OF THE PRECURSOR OF THE AMYLOID A4 PROTEIN IN SENILE PLAQUES IN ALZHEIMER'S DISEASE

1989 • 119 citations

Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

1990 • 106 citations

Quantitative histological studies on the aged human brain

1970 • 106 citations

Amyloid β-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia

1990 • 100 citations

Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta-protein of Alzheimer's disease.

1990 • 79 citations

A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles

1989 • 72 citations

Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques

1990 • 70 citations

Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

1991 • 68 citations

Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia

1990 • 46 citations

Alzheimer's neurofibrillary tangles are penetrated by astroglial processes and appear eosinophilic in their final stages

1987 • 37 citations

Degeneration of neuronal processes in rats induced by a protease inhibitor, leupeptin

1989 • 35 citations

Characterization of Antisera to Paired Helical Filaments and Tau

1990 • 33 citations

Solubility of neurofibrillary tangles and ultrastructure of paired helical filaments in sodium dodecylsulphate

1988 • 4 citations

The fine structure of eosinophilic stages of Alzheimer's neurofibrillary tangles

1983 • 3 citations