Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.

1995 • 1,714 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Soy intake and cancer risk: A review of thein vitroandin vivodata

1994 • 1,330 citations

Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

1993 • 777 citations

Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women

1994 • 746 citations

Plasma concentrations of phyto-oestrogens in Japanese men

1993 • 739 citations

Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations

1990 • 691 citations

Phytoestrogen Interaction with Estrogen Receptors in Human Breast Cancer Cells*

1978 • 605 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Bioavailability of Soybean Isoflavones Depends upon Gut Microflora in Women

1995 • 552 citations

Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens

1993 • 541 citations

Daidzein Is a More Bioavailable Soymilk Isoflavone than Is Genistein in Adult Women

1994 • 517 citations

Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)

1987 • 508 citations

Molecular effects of genistein on estrogen receptor mediated pathways

1996 • 484 citations

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cellsin vitro

1997 • 467 citations

Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene

1991 • 467 citations

Protein kinase C inhibition by plant flavonoids

1989 • 453 citations

Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells

1988 • 443 citations

Dietary phytoestrogens and cancer: in vitro and in vivo studies

1992 • 435 citations

Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat

1995 • 428 citations

Free Radical Scavenging and Antioxidant Activity of Plant Flavonoids

1994 • 384 citations

Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets

1986 • 381 citations

The E-SCREEN Assay as a Tool to Identify Estrogens: An Update on Estrogenic Environmental Pollutants

1995 • 379 citations

Commonly occurring plant flavonoids have estrogenic activity.

1993 • 359 citations

Genistein suppresses mammary cancer in rats

1995 • 343 citations

Estrogenic Flavonoids: Structural Requirements for Biological Activity

1995 • 337 citations

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

1988 • 330 citations

Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes

1994 • 320 citations

Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations

1990 • 301 citations

Genistein arrests cell cycle progression at G2-M

1995 • 294 citations

Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction.

1996 • 246 citations

Oestrogenic effects of plant foods in postmenopausal women.

1990 • 227 citations

Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture

1992 • 224 citations

Bioflavonoid interaction with rat uterine type ii binding sites and cell growth inhibition

1988 • 208 citations

Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells.

1996 • 207 citations

Dietary Estrogens Act through Estrogen Receptor-Mediated Processes and Show No Antiestrogenicity in Cultured Breast Cancer Cells.

1994 • 191 citations

Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action

1995 • 184 citations

Flavonoid inhibition of aromatase enzyme activity in human preadipocytes

1993 • 178 citations

Suppression of active oxygen-induced cytotoricity by flavonoids

1993 • 168 citations

Aromatase inhibition by flavonoids

1990 • 162 citations

Stimulation of pS2 expression by diet-derived compounds.

1994 • 149 citations

Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N′ -nitro-N-nitrosoguanidine

1989 • 129 citations

Direct effects of estrogen on c-fos and c-myc protooncogene expression and cellular proliferation in human breast cancer cells

1989 • 122 citations

Quercetin Down-Regulates Signal Transduction in Human Breast Carcinoma Cells

1995 • 110 citations

Inhibition of Proteiin-Tyrosine Kinase Activity by Flavanoids and Related Compounds

1989 • 106 citations

Estrogen regulation of proto-oncogenes coding for nuclear proteins.

1993 • 106 citations

Dietary Soybean Isolate and Methionine Supplementation Affect Mammary Tumor Progression in Rats

1991 • 94 citations

Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids

1989 • 93 citations

The effect of dietary quercetin and rutin on AOM‐induced acute colonic epithelial abnormalities in mice fed a high‐fat diet

1993 • 89 citations

Effects of plant-derived flavonoids and polyphenolic acids on the activity of mutagens from cooked food

1986 • 86 citations

Cancer chemoprevention agent development strategies for genistein.

1995 • 85 citations

Effect of flax seed ingestion on the menstrual cycle

1993 • 79 citations

Association between dietary fiber, urinary excretion of lignans and isoflavonic phytoestrogens, and plasma non-protein bound sex hormones in relation to breast cancer

1987 • 73 citations

A Sensitive Bioassay for Detection of Dietary Estrogens in Animal Feeds

1990 • 71 citations

Inhibitory Effects of Flavonoids on Moloney Murine Leukemia Virus Reverse Transcriptase Activity

1992 • 67 citations

Techniques for detection of estrogenicity.

1995 • 64 citations

Inhibition of abl Oncogene Tyrosine Kinase Induces Erythroid Differentiation of Human Myelogenous Leukemia K562 Cells

1990 • 62 citations

Effects of flavonoids on xanthine oxidation as well as on cytochrome c reduction by milk xanthine oxidase.

1986 • 61 citations

Potent Inhibition of Breast Cancer Cell Lines by the Isoflavonoid Kievitone: Comparison with Genistein

1995 • 58 citations

Are the differences between estradiol and other estrogens, naturally occurring or synthetic, merely semantical?

1996 • 50 citations

Antiproliferative effect of genistein and adriamycin against estrogen-dependent and -independent human breast carcinoma cell lines.

1994 • 45 citations

Influence of culture conditions on the estrogenic cell growth stimulation of human breast cancer cells

1990 • 35 citations

Genomic cross-talk between the estrogen receptor and growth factor regulatory pathways in estrogen target tissues.

1994 • 35 citations

Decreased growth hormone response to growth hormone-releasing hormone in Turner's syndrome: Relation to body weight and adiposity

1991 • 29 citations

Are the differences between estradiol and other estrogens, naturally occurring or synthetic, merely semantical?

1996 • 22 citations

Regulation of estrogen receptor expression

1994 • 21 citations

Session Summary: Techniques for Detection of Estrogenicity

1995 • 9 citations