Human tumor cloning assays: Applications in clinical oncology and new antineoplastic agent development

Primary Bioassay of Human Tumor Stem Cells

1977 • 1,625 citations

Clinical Prediction Rules

1985 • 1,381 citations

Quantitation of Differential Sensitivity of Human-Tumor Stem Cells to Anticancer Drugs

1978 • 982 citations

Primary Bioassay of Human Myeloma Stem Cells

1977 • 478 citations

Mouse myeloma tumor stem cells: a primary cell culture assay.

1971 • 395 citations

Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy

1981 • 378 citations

A Critical Appraisal of the Human Tumor Stem-Cell Assay

1983 • 365 citations

Prospective clinical trial of a human tumor cloning system.

1983 • 340 citations

Direct cloning of human ovarian carcinoma cells in agar.

1978 • 305 citations

An in vitro colony assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents

1978 • 296 citations

Application of a human tumor colony-forming assay to new drug screening.

1985 • 217 citations

IN-VITRO CLONOGENIC ASSAY FOR PREDICTING RESPONSE OF OVARIAN CANCER TO CHEMOTHERAPY

1980 • 165 citations

Chemosensitivity testing of human solid tumors. A review of 1582 assays with 258 clinical correlations

1984 • 131 citations

Positive correlation between histological tumor involvement and generation of tumor cell colonies in agarose in specimens taken directly from patients with small-cell carcinoma of the lung.

1980 • 114 citations

Drug and radiation sensitivity measurements of successful primary monolayer culturing of human tumor cells using cell-adhesive matrix and supplemented medium.

1986 • 107 citations

Direct cloning of human neuroblastoma cells in soft agar culture.

1980 • 97 citations

Characterization of cells obtained by mechanical and enzymatic means from human melanoma, sarcoma, and lung tumors.

1981 • 95 citations

Chemotherapy of Mouse Myeloma: Quantitative Cell Cultures Predictive of Response In Vivo

1973 • 88 citations

Activity of mitoxantrone in a human tumor cloning system.

1981 • 87 citations

Human myeloma in vitro colony growth: interrelationships between drug sensitivity, cell kinetics, and patient survival duration

1983 • 79 citations

Detection of neuroblastoma cells in bone marrow using GD2 specific monoclonal antibodies.

1986 • 77 citations

Biphasic Effect of Vanadium Salts on In Vitro Tumor Colony Growth

1987 • 72 citations

Clinical correlations with chemosensitivities measured in a rapid thymidine incorporation assay.

1984 • 70 citations

Experimental studies of the biology of human small cell lung cancer.

1983 • 66 citations

Limitations of the clonal agar assay for the assessment of primary human ovarian tumour biopsies

1982 • 60 citations

In vitro stem cell assay in head and neck squamous carcinoma

1980 • 60 citations

Improved plating efficiencies for human tumors cloned in capillary tubes versus Petri dishes.

1986 • 51 citations

Quantitation of drug sensitivity by human metastatic melanoma colony-forming units

1981 • 51 citations

Model for estimation of clinically achievable plasma concentrations for investigational anticancer drugs in man.

1986 • 50 citations

In Vitro Methods to Predict for Patient Response to Chemotherapy

1980 • 49 citations

Clinical Correlations With Drug Sensitivities in the Clonogenic Assay

1982 • 48 citations

Colony growth and chemosensitivity in vitro of human melanoma biopsies. relationship to clinical parameters

1982 • 41 citations

Activity of 9–10 anthracenedicarboxaldehyde bis[(4,5-dihydro-1 H-imidazol-2-yl)hydrazone]dihydrochloride (CL216,942) in a human tumor cloning system

1981 • 39 citations

Improved growth of in vitro colonies in human acute leukemia with the feeding culture method.

1977 • 37 citations

In vitro predictive testing: The Sulfonamide Era

1987 • 37 citations

Prospective correlative chemosensitivity testing in high-dose intraarterial chemotherapy for liver metastases.

1986 • 35 citations

Utilization of a human tumor cloning system to monitor for marrow involvement with small cell carcinoma of the lung.

1981 • 33 citations

Phase I clinical investigation of 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride with correlative in vitro human tumor clonogenic assay.

1982 • 32 citations

Factors that influence growth of head and neck squamous carcinoma in the soft agar cloning assay

1984 • 30 citations

Phase I evaluation and pharmacokinetics of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193).

1985 • 30 citations

Antitumor activity of esorubicin in human tumor clonogenic assay with comparisons to doxorubicin.

1984 • 30 citations

Clinical application of the clonogenic assay.

1983 • 29 citations

Comparison between clinical response and in vitro drug sensitivity of primary human tumors in the adhesive tumor cell culture system.

1987 • 29 citations

Colony formation in vitro as a prognostic indicator for primary breast cancer.

1987 • 26 citations

In vitro chemosensitivities of human tumor stem cells to the Phase II drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and prospective in vivo correlations.

1982 • 25 citations

Cloning efficiency. A possible prognostic indicator in squamous cell carcinoma of the head and neck

1983 • 25 citations

Predictability of response to clinical thermochemotherapy by the clonogenic assay

1983 • 25 citations

The human tumor clonogenic assay in human breast cancer.

1985 • 25 citations

Human tumor stem cell assay: A prospective clinical trial

1984 • 24 citations

In vitro chemotheraphy testing of gynecologic tumors: Basis for planning therapy?

1983 • 24 citations

Relation of in vitro colony survival to clinical response in a prospective trial of single-agent chemotherapy for metastatic melanoma.

1984 • 23 citations

Use of a human tumor cloning system to evaluate analogs of methotrexate and mitoxantrone.

1984 • 23 citations

Review of experience with interferon and drug sensitivity testing of ovarian carcinoma in semisolid agar culture

1981 • 22 citations

Breast cancer as analyzed by the human tumor stem cell assay.

1983 • 21 citations

The human tumour cloning assay in the management of breast cancer patients

1985 • 20 citations

Correlation between drug sensitivity determined by clonogenic cell assay and clinical effect of chemotherapy in patients with primary lung cancer.

1984 • 18 citations

Individualized chemotherapy in multiple myeloma by cytostatic drug sensitivity testing of colony-forming stem cells.

1981 • 15 citations

Predictive Model for Plasma Concentration-Versus-Time Profiles of Investigational Anticancer Drugs in Patientsi

1988 • 12 citations

Human tumor clonogenic assay in patients with unknown primary carcinomas.

1984 • 10 citations

Cytotoxicity of 2-Chlorodeoxyadenosine in a Human Tumor Colony-Forming Assay

1986 • 10 citations

Predictive tests for the response to cancer chemotherapy: limitations related to the prediction of rare events.

1984 • 9 citations

Soft agar clonogenic assay for predicting chemosensitivity of human tumor cells from malignant effusions.

1981 • 9 citations

Sensitivity of renal cell carcinoma to leukocyte interferon in the human tumor clonogenic assay and clinical correlations

1984 • 8 citations

Use of the human tumor stem cell assay to study chemotherapy sensitivity in cancer of the cervix.

1984 • 8 citations

In vitro assessment of antineoplastic therapy

1981 • 8 citations

Clonogenic in vitro growth and histologic grading of primary human breast tumors

1985 • 8 citations

Chemosensitivities of human clonogenic breast tumor cells

1986 • 8 citations

Human tumor stem cell clonogenic assay sensitivity in malignant tumors and clinical correlation.

1982 • 7 citations

Prognostic evaluation of human tumor cell in vitro cloning assay.

1982 • 6 citations

[In vitro resistance testing of tumors in relation to cytostatics. 2. Examinations with human malignomas].

1980 • 5 citations

Long-distance transportation of specimens for human tumor cloning.

1982 • 4 citations

Experience with the colony-forming (stem cell) assay of in vitro chemosensitivity in the management of patients with advanced malignant melanoma.

1984 • 3 citations

In Vitro Assessment of the Therapeutic Value of Antineoplastic Agents

1982 • 3 citations

Potential therapeutic and diagnostic applications of the growth of testicular cancer in soft agar

1983 • 3 citations