An update on superoxide dismutase 1 in familial amyotrophic lateral sclerosis

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction

1995 • 683 citations

Superoxide Dismutase Activity, Oxidative Damage, and Mitochondrial Energy Metabolism in Familial and Sporadic Amyotrophic Lateral Sclerosis

1993 • 627 citations

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

1994 • 604 citations

Superoxide and superoxide dismutases

1993 • 518 citations

Superoxide Dismutases

1986 • 450 citations

Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin β2

1995 • 447 citations

Familial adult motor neuron disease: amyotrophic lateralsclerosis

1986 • 401 citations

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.

1994 • 397 citations

Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity

1991 • 373 citations

Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in management

1985 • 369 citations

A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease

1994 • 356 citations

Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase

1995 • 318 citations

Onset, natural history and outcome in idiopathic adult motor neuron disease

1993 • 293 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.

1985 • 251 citations

Merritt's Textbook of Neurology.

1991 • 224 citations

Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors

1994 • 223 citations

Epidemiologic Investigations of Amyotrophic Lateral Sclerosis

1955 • 181 citations

Rapid Communication: Cu/Zn Superoxide Dismutase Activity in Familial and Sporadic Amyotrophic Lateral Sclerosis

1994 • 161 citations

Superoxide Dismutase 1 Subunits with Mutations Linked to Familial Amyotrophic Lateral Sclerosis Do Not Affect Wild-type Subunit Function

1995 • 149 citations

superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

1994 • 149 citations

The natural history of motoneuron loss in amyotrophic lateral sclerosis

1988 • 146 citations

Superoxide Dismutase Concentration and Activity in Familial Amyotrophic Lateral Sclerosis

1995 • 125 citations

Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis.

1995 • 109 citations

Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis.

1994 • 98 citations

Familial motor neuron disease

1976 • 94 citations

Familial Amyotrophic Lateral Sclerosis, 1850-1989: A Statistical Analysis of the World Literature

1991 • 90 citations

Identification of a novel S0D1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of lle113Thr in three others

1994 • 88 citations

A Novel Mutation in Cu/Zn Superoxide Dismutase Gene in Japanese Familial Amyotrophic Lateral Sclerosis

1994 • 84 citations

Epidemiologic Investigations of Amyotrophic Lateral Sclerosis

1955 • 79 citations

Impaired copper binding by the H46R mutant of human Cu,Zn superoxide dismutase, involved in amyotrophic lateral sclerosis

1994 • 77 citations

Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis

1994 • 77 citations

Variance of age at onset in a Japanese family with amyotrophic lateral sclerosis associated with a novel cu/zn superoxide dismutase mutation

1995 • 70 citations

Identification of a new missense point mutation in exon 4 of the Cu/Zn superoxide dismutase (SOD-1) gene in a family with amyotrophic lateral sclerosis

1994 • 70 citations

A two basepair deletion in the SOD 1 gene causes familial amyotrophic lateral sclerosis.

1994 • 66 citations

Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis

1995 • 58 citations

Differences in the pharmacokinetic properties of orally administered all-trans-retinoic acid and 9-cis-retinoic acid in the plasma of nude mice.

1994 • 58 citations

Motor neurone disease and animal models

1994 • 58 citations

An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon ⁴

1995 • 57 citations

Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis

1996 • 52 citations

IMMUNOHISTOCHEMICAL DEMONSTRATION OF Cu/Zn SUPEROXIDE DISMUTASE IN THE SPINAL CORD OF PATIENTS WITH FAMILIAL AMYOTRO-PHIC LATERAL SCLEROSIS

1993 • 51 citations

Two novel mutations in the gene for coppe zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis

1995 • 50 citations

A novel two-base mutation in the superoxide dismutase gene associated with familial amyotrophic lateral sclerosis in Japan

1996 • 45 citations

Autosomal dominant amyotrophic lateral sclerosis: a novel mutation in the Cu/Zn superoxide dismutase-1 gene

1994 • 39 citations

Motor neuron disease caused by mutations in superoxide dismutase 1

1995 • 36 citations

The D90A mutation results in a polymorphism of Cu, Zn superoxide dismutase that is prevalent in northern Sweden and Finland

1995 • 32 citations

A novel point mutation in the Cu/Zn superoxide dismutase gene in a patient with familial amyotrophic lateral sclerosis

1995 • 26 citations

Spinal cord TRH deficiency is associated with incomplete recovery of denervated muscle in the rat

1988 • 26 citations

Mutations in Cu/Zn superoxide dismutase (SOD1) are associated with familial amyotrophic lateral sclerosis (ALS)

1993 • 12 citations