Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats

1962 • 638 citations

Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning

1985 • 516 citations

ACUTE REGULATION OF TYROSINE HYDROXYLASE BY NERVE ACTIVITY AND BY NEUROTRANSMITTERS VIA PHOSPHORYLATION

1989 • 487 citations

Opioid receptor-coupled second messenger systems

1991 • 466 citations

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

1990 • 317 citations

Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.

1988 • 280 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

Self-administration of methionine enkephalin into the nucleus accumbens

1984 • 238 citations

Depression of Mesolimbic Dopamine Transmission and Sensitization to Morphine During Opiate Abstinence

1992 • 224 citations

Morphine and Cocaine Exert Common Chronic Actions on Tyrosine Hydroxylase in Dopaminergic Brain Reward Regions

1991 • 211 citations

Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of μ- and κ-opioid agonists

1987 • 189 citations

Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes

1984 • 168 citations

Motivational properties of opioids: evidence that an activation of σ-receptors mediates reinforcement processes

1987 • 167 citations

Opposite motivational effects of endogenous opioids in brain and periphery

1985 • 166 citations

Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens

1991 • 156 citations

Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal

1989 • 145 citations

Autoradiographic localization of μ-opioid and neurotensin receptors within the mesolimbic dopamine system

1989 • 143 citations

Mixed-inhibitor-prodrug as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

1992 • 139 citations

Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid δ and dopamine D1 receptor stimulation

1992 • 125 citations

Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus.

1984 • 121 citations

A topographic localization of enkephalin on the dopamine neurons of the rat substantia nigra and ventral tegmental area demonstrated by combined histofluorescence-immunocytochemistry

1980 • 121 citations

Facilitation of self-stimulation behavior following intracerebral microinjections of opioids into the ventral tegmental area

1979 • 120 citations

Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.

1992 • 116 citations

A rapid and inexpensive technique for assessing the reinforcing effects of opiate drugs

1979 • 108 citations

Neural basis of psychomotor stimulant and opiate reward: Evidence suggesting the involvement of a common dopaminergic system

1986 • 102 citations

Reward produced by microinjection of (d-Ala2),Met5-enkephalinamide into the ventral tegmental area

1982 • 100 citations

Effects of 6-OHDA lesions of the central medial nucleus accumbens on rat intravenous morphine self-administration

1985 • 86 citations

Conditioned Drug Effects on Spatial Preference: Critical Evaluation

2003 • 77 citations

Pertussis toxin abolishes μ- and δ-opioid agonist-induced place perference

1991 • 65 citations

The effects of low doses of morphine on the activity of dopamine-containing cells and on behavior

1982 • 61 citations

Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine

1992 • 57 citations

In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding

1992 • 54 citations

Naloxone enhances the expression of morphine-induced conditioned place preference

1990 • 52 citations

Endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain.

1984 • 51 citations

6-OHDA lesions of the ventral tegmental area block morphine-induced but not amphetamine-induced facilitation of self-stimulation

1985 • 51 citations

Conditioned place preference produced by infusion of Met-enkephalin into the medial preoptic area

1991 • 50 citations

Enkephalin Degrading Enzyme Inhibitors: A Physiological Way to New Analgesics and Psychoactive Agents

1986 • 48 citations

Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101

1992 • 45 citations

Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine

1992 • 42 citations

Endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain.

1984 • 41 citations

Opioid peptides: molecular pharmacology, biosynthesis, and analysis.

1986 • 33 citations

Using antagonists to assess neurochemical coding of a drug's ability to establish a conditioned place preference

1990 • 27 citations

Morphine-induced place conditioning is not confounded by drug-induced alterations in locomotor activity

1989 • 25 citations

Dose-dependent and baseline-dependent conditioning with d-amphetamine in the place conditioning paradigm

1989 • 23 citations

Heroin and morphine: Aversive and analgesic effects in rats

1981 • 23 citations

Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J AND DBA/2J)

1989 • 19 citations

Kelatorphan, a potent enkephalinases inhibitor, and opioid receptor agonists DAGO and DTLET, differentially modulate self-stimulation behaviour depending on the site of administration

1989 • 18 citations

Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum

1990 • 7 citations