The Proteolytic Cleavage of Protein Kinase C Isotypes, Which Generates Kinase and Regulatory Fragments, Correlates with Fas‐Mediated and 12‐O‐Tetradecanoyl‐Phorbol‐13‐Acetate‐Induced Apoptosis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

A License to Kill

1996 • 649 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.

1979 • 513 citations

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis

1996 • 484 citations

Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)

1989 • 470 citations

Calpain activation in apoptosis

1994 • 445 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.

1994 • 356 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

1993 • 306 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate.

1996 • 204 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

The lipid binding, regulatory domain of protein kinase C. A 32-kDa fragment contains the calcium- and phosphatidylserine-dependent phorbol diester binding activity.

1986 • 140 citations

Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.

1995 • 133 citations

Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.

1994 • 131 citations

ICE/CED-3 proteasesin apoptosis

1996 • 128 citations

Activation of protein kinase Cdelta in human myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine

1996 • 119 citations

Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C

1987 • 117 citations

Relationship between Apoptosis and the Cell Cycle in Lymphocytes: Roles of Protein Kinase C, Tyrosine Phosphorylation, and AP1

1993 • 111 citations

Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta.

1994 • 111 citations

Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ

1991 • 105 citations

Regulation of protein kinase C isoform proteins in phorbol ester-stimulated Jurkat T lymphoma cells.

1993 • 97 citations

Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate.

1994 • 90 citations

Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester.

1990 • 89 citations

Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-d-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells

1994 • 86 citations

Expression and Biochemical Characterization of Human Protein Kinase C‐θ

1994 • 83 citations

Protein Kinase C Domains Involved in Interactions with Other Proteins

1994 • 82 citations

Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts

1994 • 80 citations

Purification and characterization of protein kinase C .epsilon. from rabbit brain

1992 • 77 citations

Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.

1992 • 75 citations

Conversion of protein kinase C from a Ca2+-dependent to an independent form of phorbol ester-binding protein by digestion with trypsim

1986 • 74 citations

Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.

1995 • 68 citations

Phorbol ester treatment of U937 cells with altered protein kinase C content and distribution induces cell death rather than differentiation.

1995 • 56 citations

Dissimilar effects of phorbol ester and diacylglycerol derivative on protein kinase activity in the monoblastoid U937 cell.

1987 • 53 citations

Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils.

1990 • 53 citations

Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M

1993 • 50 citations

Role of cofactors in protein kinase C activation

1992 • 48 citations

Degradation of protein kinase Cα and its free catalytic subunit, protein kinase M, in intact human neuroblastoma cells and under cell‐free conditions

1994 • 47 citations

Protein kinase C activation promotes cell survival in mature lymphocytes prone to apoptosis

1994 • 45 citations

Downregulation of Protein Kinase C Suppresses Induction of Apoptosis in Human Prostatic Carcinoma Cells

1996 • 40 citations

Calpain Inhibitor-Induced Apoptosis in Human Prostate Adenocarcinoma Cells

1995 • 36 citations

Catalytic fragment of protein kinase C exhibits altered substrate specificity toward smooth muscle myosin light chain

1991 • 33 citations

Effect of phorbol esters on cytosolic protein kinase C content and activity in the human monoblastoid U937 cell.

1991 • 31 citations

Characterization of human TUR leukemia cells: continued cell cycle progression in the presence of phorbol ester is associated with resistance to apoptosis.

1994 • 26 citations

The involvement of protein kinase C in activation-induced cell death in T-cell hybridoma

1992 • 26 citations

Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells

1997 • 24 citations

A link between cell-surface receptors and ICE proteases

1996 • 12 citations

Sodium benzylideneascorbate induces apoptosis in HIV‐replicating U1 cells

1994 • 4 citations