Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

Behavioral despair in mice: a primary screening test for antidepressants.

1977 • 3,241 citations

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

1995 • 1,800 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

Pharmacology of nociceptin and its receptor: a novel therapeutic target

2000 • 426 citations

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

1997 • 351 citations

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: Anxiolytic profile in the rat

2000 • 272 citations

Increase by the ORL₁ receptor (opioid receptor‐like₁) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

1996 • 231 citations

Address and Message Sequences for the Nociceptin Receptor: A Structure−Activity Study of Nociceptin-(1−13)-peptide amide

1997 • 215 citations

Sex differences in emotional behaviour in the rat: Correlation between open-field defecation and active avoidance

1974 • 145 citations

Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system

2000 • 117 citations

Nociceptin inhibits noradrenaline release in the mouse brain cortex via presynaptic ORL1 receptors

1998 • 81 citations

Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identification of a selective antagonist

2000 • 81 citations

Modulation of 5‐hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin

2000 • 72 citations

Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms

1998 • 68 citations

Inhibitory effect of nociceptin on [³H]‐5‐HT release from rat cerebral cortex slices

1999 • 62 citations

Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice

2001 • 55 citations

In vitro characterization of J-113397, a non-peptide nociceptin/orphanin FQ receptor antagonist

2000 • 50 citations

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

2000 • 45 citations

Further characterization of the ORL₁ receptor‐mediated inhibition of noradrenaline release in the mouse brain in vitro

1999 • 37 citations