Human C‐ERBB‐2 proto‐oncogene product as a target for bispecific‐antibody‐directed adoptive tumor immunotherapy

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Adoptive Immunotherapy of Established Pulmonary Metastases with LAK Cells and Recombinant Interleukin-2

1984 • 687 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.

1989 • 479 citations

Hybrid antibodies can target sites for attack by T cells

1985 • 479 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody

1985 • 339 citations

Preliminary trial of specific targeting therapy against malignant glioma

1990 • 241 citations

Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts

1961 • 215 citations

Human T cells targeted with anti-T3 cross-linked to antitumor antibody prevent tumor growth in nude mice.

1987 • 89 citations

Frequency and surface phenotype of human T lymphocytes producing interleukin 2. Analysis by limiting dilution and cell cloning

1985 • 75 citations

Protein kinase C required for cytotoxic T lymphocyte triggering.

1987 • 74 citations

Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies.

1985 • 59 citations

Bispecific antibodies and targeted cellular cytotoxicity

1991 • 57 citations

Targeted cytotoxic cells in human peripheral blood lymphocytes.

1990 • 53 citations

Thymic stromal cell clone with nursing activity supports the growth and differentiation of murine CD4+8+ thymocytes in vitro.

1990 • 50 citations

Bispecific F(ab′)₂ monomer prepared with anti‐CD3 and anti‐tumor monoclonal antibodies is most potent in induction of cytolysis of human T cells

1989 • 49 citations

A Murine Monoclonal Antibody that Recognizes an Extracellular Domain of the Human c‐erbB‐2 Protooncogene Product

1989 • 46 citations

Induction of cytotoxicity in human peripheral blood mononuclear cells by monoclonal antibody OKT3.

1987 • 44 citations

Induction of cytotoxicity in human T cells coated with anti-glioma × anti-CD3 bispecific antibody against human glioma cells

1990 • 39 citations

Generation propagation, and targeting of human CD4+ helper/killer T cells induced by anti-CD3 monoclonal antibody plus recombinant IL-2. An efficient strategy for adoptive tumor immunotherapy.

1992 • 35 citations

Mechanism of inhibition and induction of cytolytic activity in cytotoxic T lymphocytes by CD3 monoclonal antibodies.

1987 • 30 citations

Administration of slowly released recombinant interleukin 2 Augmentation of the efficacy of adoptive immunotherapy with lymphokine-activated killer (LAK) cells

1986 • 25 citations

Significance of T4 or T8 Phenotype of Human Cytotoxic T-Lymphocyte Clones

1986 • 16 citations

Macrophage–T Cell Interaction Is Essential for the Induction of p75 Interleukin 2 (IL–2) Receptor and IL–2 Responsiveness in Human CD4⁺ T Cells

1991 • 13 citations

Bispecific Antibody‐directed Antitumor Activity of Human CD4⁺ Helper/Killer T Cells Induced by Anti–CD3 Monoclonal Antibody plus Interleukin 2

1991 • 9 citations