α₁‐Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline

Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal Condition

1964 • 7,448 citations

Periodontal Disease in Pregnancy I. Prevalence and Severity

1963 • 6,901 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs

1991 • 522 citations

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

1968 • 456 citations

Minocycline reduces gingival collagenolytic activity during diabetes

1983 • 415 citations

Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.

1994 • 381 citations

A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity

1987 • 307 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

Doxycycline inhibits neutrophil (PMN)‐type matrix metalloproteinases in human adult periodontitis gingiva

1995 • 277 citations

Low‐dose doxycycline therapy: Effect on gingival and crevicular fluid collagenase activity in humans

1990 • 228 citations

Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources

1985 • 215 citations

Conformation of the reactive site loop of .alpha.1-proteinase inhibitor probed by limited proteolysis

1992 • 197 citations

The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes.

1987 • 196 citations

Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals.

1986 • 178 citations

Matrix metalloproteinases and their inhibition in periodontal treatment.

1996 • 168 citations

The latent collagenase and gelatinase of human polymorphonuclear neutrophil leucocytes

1980 • 168 citations

Gingival Fluid and Serum in Periodontal Diseases: I. Quantitative Study of Immunoglobulins, Complement Components, and Other Plasma Proteins

1977 • 165 citations

Suppression of human neutrophil functions by tetracyclines

1991 • 160 citations

Blocking Periodontal Disease Progression by Inhibiting Tissue‐Destructive Enzymes: A Potential Therapeutic Role for Tetracyclines and Their Chemically‐Modified Analogs

1993 • 149 citations

Elastase as an Indicator of Periodontal Disease Progression

1992 • 144 citations

The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant.

1988 • 139 citations

Matrilysin Is Much More Efficient Than Other Matrix Metalloproteinases in the Proteolytic Inactivation of α1-Antitrypsin

1994 • 128 citations

Longitudinal Evaluation of Elastase as a Marker for the Progression of Periodontitis

1994 • 119 citations

Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.

1992 • 114 citations

A Non‐Antimicrobial Tetracycline Inhibits Gingival Matrix Metalloproteinases and Bone Loss in Porphyromonas gingivalis‐induced Periodontitis in Rats^a

1994 • 110 citations

Proteases and their inhibitors in chronic inflammatory periodontal disease

1986 • 106 citations

Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase

1993 • 103 citations

Imbalance between 95 kDa type IV collagenase and tissue inhibitor of metalloproteinases in sputum of patients with cystic fibrosis.

1995 • 101 citations

Inhibition of neutrophil superoxide production by human plasma α₁‐antitrypsin

1992 • 99 citations

Human neutrophil collagenase cleaves α1-antitrypsin

1990 • 98 citations

The “Cyclic” Regimen of Low‐Dose Doxycycline for Adult Periodontitis: A Preliminary Study

1996 • 91 citations

Neutrophil Elastase and its Inhibitors in Human Gingival Crevicular Fluid during Experimental Gingivitis

1992 • 90 citations

Treating Periodontal Diieases by Blocking Tissue-Destructive Enzymes

1994 • 87 citations

Inactivation of human plasma α₁‐proteinase inhibitor by human PMN leucocyte collagenase

1990 • 65 citations

Proteolytic inactivation of human α₁ antitrypsin by human stromelysin

1991 • 64 citations

Effect of Alpha-1-Proteinase Inhibitor on Neutrophil Chemotaxis

1990 • 59 citations

Scavenging of hypochlorous acid by tetracycline, rifampicin and some other antibiotics: a possible antioxidant action of rifampicin and tetracycline?

1988 • 59 citations

The ability of gingival crevicular fluid acute phase proteins to distinguish healthy, gingivitis and periodontitis sites

1992 • 55 citations

Use of anti-collagenase properties of doxycycline in treatment of alpha 1-antitrypsin deficiency panniculitis.

1991 • 53 citations

Functional Inactivation and Structural Disruption of Human α2-Macroglobulin by Neutrophils and Eosinophils

1989 • 49 citations

Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase

1993 • 45 citations

Neutrophil collagenase in sputum from patients with cystic fibrosis.

1994 • 39 citations

Elastase and α‐₁‐Proteinase Inhibitor in Gingival Crevicular Fluid and Gingival Tissue in Adult and Juvenile Periodontitis

1994 • 33 citations

The effect of treatment on IgG, IgA, IgM and α-2-macroglobulin in gingival crevicular fluid from patients with chronic adult periodontitis

1988 • 32 citations

Synthesis of α2-macroglobulin in human gingiva: A study of the concentration of macroglobulin and albumin in gingival fluid and serum

1990 • 27 citations

A collagenase assay using [3H-methyl]collagen

1981 • 24 citations

Human α₁-Proteinase Inhibitor Binds to Extracellular Matrix In Vitro

1993 • 21 citations

Endotoxin Abolishes the Induction of α2-Macroglobulin Synthesis in Cultured Human Monocytes Indicating Inhibition of the Terminal Monocyte Maturation into Macrophages

1988 • 4 citations