Mechanisms underlying pressure-related natriuresis: the role of the renin-angiotensin and prostaglandin systems. State of the art lecture.

On the local reactions of the arterial wall to changes of internal pressure

1902 • 1,485 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

1985 • 1,237 citations

Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs

1984 • 1,098 citations

Arterial pressure regulation

1972 • 1,044 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Prostaglandins: Their Disappearance from and Release into the Circulation

1967 • 898 citations

Mechanisms regulating renin release

1976 • 886 citations

The pharmacologic alteration of renin release.

1980 • 518 citations

Increased Production of Prostaglandin D2 in Patients with Systemic Mastocytosis

1980 • 430 citations

Contraction of Cultured Rat Glomerular Cells of Apparent Mesangial Origin after Stimulation with Angiotensin II and Arginine Vasopressin

1980 • 400 citations

Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney

1977 • 368 citations

Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.

1977 • 351 citations

Primary role of renal homografts in setting chronic blood pressure levels in rats.

1975 • 349 citations

Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules.

1984 • 338 citations

Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion.

1979 • 338 citations

Changes in Renal Blood Flow, Extraction of Inulin, Glomerular Filtration Rate, Tissue Pressure and Urine Flow With Acute Alterations of Renal Artery Blood Pressure

1951 • 327 citations

Diastolic coronary artery pressure-flow relations in the dog.

1978 • 300 citations

Bovine endothelial cells in culture produce thromboxane as well as prostacyclin.

1981 • 300 citations

Prostacyclin is not a circulating hormone in man

1982 • 290 citations

Estimated rate of prostacyclin secretion into the circulation of normal man.

1981 • 271 citations

Renal effects of drugs that inhibit prostaglandin synthesis

1980 • 270 citations

The secretion of urine as studied on the isolated kidney

1925 • 245 citations

Structural organization of the renal medulla: comparative and functional aspects

1981 • 240 citations

Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex

1978 • 232 citations

Contribution of the renin-angiotensin system to the control of intrarenal hemodynamics

1984 • 216 citations

The effects of combined renal vasodilatation and pressor agents on renal hemodynamics and the tubular reabsorption of sodium.

1966 • 208 citations

Evidence for a Direct Stimulatory Effect of Prostacyclin on Renin Release in Man

1982 • 208 citations

Prostaglandins and other arachidonic acid metabolites in the kidney

1986 • 206 citations

Prostaglandins and renin release: I. Stimulation of renin release from rabbit renal cortical slices by PGI2

1977 • 199 citations

Prostaglandin Biosynthesis and its Compartmentation in Vascular Smooth Muscle and Endothelial Cells

1986 • 195 citations

INFLUENCE OF GRADED ARTERIAL PRESSURE DECREMENT ON RENAL CLEARANCE OF CREATININE, P-AMINOHIPPURATE AND SODIUM

1949 • 190 citations

Incorporation of cytoplasmic vesicles into apical membrane of mammalian urinary bladder epithelium

1982 • 189 citations

Indomethacin-Induced Prostaglandin Inhibition with Hyperkalemia

1979 • 185 citations

The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia

1984 • 180 citations

Defect in the sodium-modulated tissue responsiveness to angiotensin II in essential hypertension.

1983 • 178 citations

Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells.

1981 • 166 citations

Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultivated coronary microvessel endothelial cells.

1983 • 155 citations

Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta.

1983 • 148 citations

Renal and circulatory mechanisms in congestive heart failure

1987 • 137 citations

Angiotensin II in arterial and renal venous plasma and renal lymph in the dog

1971 • 136 citations

Abnormal renal sodium handling in essential hypertension

1986 • 133 citations

Basal and stimulated rates of renal secretion and excretion of prostaglandins E2, Fα, and 13,14-dihydro-15-keto Fα in the dog

1978 • 125 citations

Second messengers in renin secretion

1985 • 123 citations

Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.

1980 • 110 citations

The ultrastructure of the rat renal medulla as observed after improved fixation methods

1974 • 107 citations

Evidence for mesangial glomerular receptors for angiotensin II linked to mesangial cell contractility

1980 • 107 citations

PGI2 production by rat blood vessels: Diminished prostacyclin formation in veins compared to arteries

1978 • 106 citations

Mechanism of natriuresis and diuresis during elevated renal arterial pressure

1965 • 103 citations

Mechanisms of angiotensin II natriuresis and antinatriuresis

1985 • 101 citations

Angiotensin II Binding Sites on Isolated Rat Renal Brush Border Membranes*

1982 • 100 citations

Histochemical localisation of prostaglandin synthetase

1971 • 90 citations

Angiotensin II-Binding Sites in Rat and Primate Isolated Renal Tubular Basolateral Membranes*

1983 • 89 citations

Effect of renal perfusion pressure on sodium reabsorption from proximal tubules of superficial and deep nephrons

1986 • 89 citations

Is prostacyclin a physiologically important circulating anti-platelet agent?

1980 • 88 citations

Glomerular Hemodynamics in Rats with Chronic Sodium Depletion

1979 • 87 citations

Regulation of papillary plasma flow by angiotensin II

1987 • 87 citations

Metabolism of prostacyclin in the rabbit kidney.

1979 • 82 citations

Regulation of Vasopressin Action by Prostaglandins

1982 • 81 citations

Control of glomerular filtration rate by circulating angiotensin II

1981 • 80 citations

Angiotensin II receptors in the kidney.

1986 • 78 citations

Regulation of glomerular filtration rate and sodium excretion by angiotensin II.

1986 • 78 citations

Intrarenal role of angiotensin II and [des-Asp1]angiotensin II

1979 • 77 citations

The fine structure of the blood vessels of the renal medulla with particular reference to the control of the medullary circulation

1967 • 76 citations

Hyperkalemia Associated With Indomethacin

1981 • 73 citations

Participation of renal cortical prostaglandins in the regulation of glomerular filtration rate

1981 • 71 citations

Antibodies which antagonise the effects of prostacyclin

1978 • 70 citations

Effect of beta-adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation

1975 • 69 citations

Role of hydrostatic and oncotic pressures in renal sodium reabsorption.

1983 • 68 citations

Evidence of Prostacyclin Deficiency in the Syndrome of Hyporeninemic Hypoaldosteronism

1986 • 65 citations

Prostacyclin produced by the pregnant uterus in the dog may act as a circulating vasodepressor substance.

1981 • 64 citations

Angiotensin II receptor regulation in isolated renal glomeruli.

1983 • 63 citations

Effect of prostaglandins on renal epithelial electrolyte transport

1981 • 61 citations

Angiotensin II and prostaglandins in control of vasa recta blood flow

1988 • 61 citations

Angiotensin II: evidence for its role as an intrarenal hormone.

1982 • 60 citations

Abolition by calcium antagonists of the autoregulation of renal blood flow

1974 • 60 citations

Role of proximal convoluted tubule in pressure diuresis in the rat

1986 • 58 citations

Direct evidence for myogenic autoregulation of the renal microcirculation in the hamster.

1980 • 57 citations

Calcium-dependent contractile activation of cerebral artery produced by quick stretch

1982 • 53 citations

Identification of an angiotensin receptor in rabbit renomedullary interstitial cells in tissue culture. Correlation with prostaglandin biosynthesis.

1980 • 51 citations

Low renal papillary plasma flow in both Dahl and Kyoto rats with spontaneous hypertension.

1976 • 51 citations

Pressure diuresis mechanism in the control of renal function and arterial pressure.

1986 • 50 citations

Vasopressin-prostaglandin interactions in isolated tubules from rat outer medulla.

1980 • 48 citations

Circadian Rhythm of Plasma Renin Activity in Older Normal and Essential Hypertensive Men: Relation with Inactive Renin, Aldosterone, Cortisol and REM Sleep

1986 • 47 citations

Stretch-induced phosphorylation of the 20,000-dalton light chain of myosin in arterial smooth muscle.

1983 • 46 citations

Renal inner medullary prostaglandin synthesis. A calcium-calmodulin-dependent process suppressed by urea.

1981 • 45 citations

Prostaglandins in the sodium excretory response to altered renal arterial pressure in dogs

1985 • 45 citations

Effect of peritubular infusion of angiotensin II on rat proximal nephron function

1974 • 45 citations

Regulation of prostaglandin E2 synthesis by angiotensin II, potassium, osmolality, and dexamethasone

1980 • 44 citations

Angiotensin-mediated alterations in nephron function in Goldblatt hypertensive rats

1982 • 44 citations

The medullary microcirculation

1987 • 43 citations

Acute renal artery constriction increases renal prostaglandin I2 biosynthesis and renin release in the conscious dog.

1982 • 43 citations

Intrarenal mechanisms mediating pressure natriuresis: role of angiotensin and prostaglandins.

1986 • 42 citations

The Ultrastructure of the Renal Medulla and the Interstitial Cells

1980 • 42 citations

Turnover, Membrane Insertion, and Degradation of Sodium Channels in Rabbit Urinary Bladder

1983 • 41 citations

Contribution of angiotensin to the control of medullary hemodynamics.

1986 • 39 citations

A Method for Measurement of Angiotensin II in Tissues and its Application to Rat Kidney

1976 • 37 citations

Effects of locally formed angiotensin II on renal hemodynamics.

1986 • 37 citations

Synthesis of prostaglandin E2 in different segments of isolated collecting tubules from adult and neonatal rabbits

1985 • 37 citations

Calcium ion dependence of myogenic renal plasma flow autoregulation: evidence from the isolated perfused rat kidney.

1982 • 36 citations

Kallikrein-kinin and renin-angiotensin systems in rat renal lymph

1984 • 35 citations

Influence of tissue pressure on renal blood flow autoregulation

1964 • 35 citations

EFFECTS OF ELEVATED URETERAL PRESSURE ON RENAL BLOOD FLOW.

1964 • 33 citations

Prostaglandin-E2 receptors in the rat kidney: Biochemical characterization and localization

1987 • 31 citations

The influence of increase of ureter pressure on the isolated mammalian kidney

1931 • 30 citations

The antihypertensive function of the kidney. Its elucidation by captopril plus unclipping.

1985 • 30 citations

Renal Hypoprostaglandism, Hypertension, and Type IV Renal Tubular Acidosis Reversed by Furosemide

1983 • 29 citations

SOME MATHEMATICAL FORMS OF AUTOREGULATORY MODELS.

1964 • 28 citations

Cytochemical localization of endogenous peroxidase activity in renal medullary collecting tubules and papillary mucosa of the rat.

1976 • 28 citations

Effects of long-term treatment with indomethacin on renal function.

1986 • 27 citations

Regulation of renal hemodynamics.

1982 • 26 citations

Renin-angiotensin system and renal circulation in clinical congestive heart failure.

1987 • 26 citations

Prostaglandin synthesis by isolated cells from the outer medulla and from the thick ascending loop of Henle of rabbit kidney.

1982 • 25 citations

Prostaglandin receptors in rat kidney

1984 • 23 citations

Prostaglandin blockade blunts the natriuresis of elevated renal interstitial hydrostatic pressure

1988 • 23 citations

Platelet Interactions with the Endothelium and the Subendothelium: the Role of Thrombin and Prostacyclin

1979 • 21 citations

Interrelationship of blood flow, juxtaglomerular cells, and hypertension: role of physical equilibrium and Ca

1986 • 21 citations

Absence of direct effects of prostaglandins on sodium chloride transport in the mammalian nephron

1981 • 20 citations

Calcium-dependent stimulation of renal medullary prostaglandin synthesis by furosemide.

1982 • 20 citations

Pressure Diuresis in Dogs with Diabetes Insipidus

1971 • 19 citations

Location of [¹²⁵I]‐angiotensin II receptors on rat kidney cortex epithelial cells

1984 • 19 citations

The effect of indomethacin on autoregulation of renal blood flow in the anasthetized dog.

1977 • 19 citations

The humorally mediated antihypertensive system of the rat kidney: a physiological depressor mechanism?

1987 • 16 citations

Influence of angiotensins (I, II & III) on prostaglandin production by minced rat renal medulla

1981 • 8 citations

Role of transmural pressure in local regulation of blood flow through kidney

1965 • 6 citations