Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

GABA_A Receptor Channels

1994 • 1,948 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

APRIORITY

1961 • 1,293 citations

A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease

1994 • 953 citations

Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.

1991 • 338 citations

Modification of the binding properties of muscarinic receptors by gallamine.

1983 • 321 citations

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

1995 • 259 citations

A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group

1994 • 164 citations

Allosteric modulation of muscarinic acetylcholine receptors

1995 • 155 citations

Benzodiazepines on trial: a research strategy for their rehabilitation

1996 • 144 citations

Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis.

1995 • 130 citations

Allosteric antagonists of the muscarinic acetylcholine receptor

1991 • 102 citations

Allosteric regulation of cloned m1–m5 muscarinic receptor subtypes

1991 • 101 citations

Chapter 34 The cholinergic system in Alzheimer disease

1990 • 98 citations

Drug design for neuroscience

1994 • 92 citations

Drug design for neuroscience

1993 • 79 citations

Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium.

1983 • 78 citations

Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site.

1996 • 71 citations

New functionally selective muscarinic agonists

1993 • 47 citations

The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vivo

1993 • 47 citations

Receptor biochemistry: A practical approach

1993 • 44 citations

Competition between positive and negative allosteric effectors on muscarinic receptors.

1995 • 42 citations

Receptor biochemistry: A practical approach

1991 • 35 citations

Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium.

1988 • 34 citations

Preclinical and Phase 1 clinical characterization of CI-979/ RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease

1995 • 30 citations

Phase I clinical trials with WAL 2014, a new muscarinic agonist for the treatment of Alzheimer's disease

1995 • 28 citations

In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832

1995 • 21 citations