The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vivo

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.

1989 • 627 citations

Localization of a family of muscarinic receptor mRNAs in rat brain

1988 • 472 citations

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors

1990 • 130 citations

Relative affinities of drugs acting at cholinoceptors in displacing agonist and antagonist radioligands: the NMS/Oxo‐M ratio as an index of efficacy at cortical muscarinic receptors

1988 • 108 citations

Pharmacological differences between two muscarinic responses of the rat superior cervical ganglion in vitro

1987 • 54 citations

Predicting the biologically conformations of short polypeptides

1989 • 44 citations

Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives

1992 • 43 citations

Direct measurement of muscarinic agents in the central nervous system of mice using ex vivo binding

1989 • 31 citations

A novel series of non‐quaternary oxadiazoles acting as full agonists at muscarinic receptors

1990 • 30 citations

Central effects of muscarinic agonists and antagonists on hippocampal theta rhythm and blood pressure in the anaesthetised rat

1991 • 22 citations

In vivo characterisation of novel efficacious muscarinic receptor agonists

1990 • 15 citations

Characterization of rat liver β‐adrenoceptors during perinatal development as determined by [¹²⁵I]‐iodopindolol radioligand binding assays

1988 • 10 citations

Deleted Work

1955 • 0 citations