New Approaches to Specific Immunomodulation in Transplantation

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Indirect presentation of MHC antigens in transplantation

1994 • 362 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

T cell receptor antagonists and partial agonists

1995 • 303 citations

T cell activation via Leu-23 (CD69).

1989 • 296 citations

CHRONIC REJECTION—AN UNDEFINED CONUNDRUM

1991 • 291 citations

The molecular basis of alloreactivity

1990 • 278 citations

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.

1992 • 266 citations

Contribution of direct and indirect recognition pathways to T cell alloreactivity.

1993 • 242 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

Mechanisms influencing the immunodominance of T cell determinants.

1988 • 227 citations

Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.

1994 • 227 citations

Allelic variation in the DR subregion of the human major histocompatibility complex.

1987 • 220 citations

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

1992 • 218 citations

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.

1994 • 216 citations

Predominant use of a Vα gene segment in mouse T-cell receptors for cytochrome c

1986 • 206 citations

THE ROLE OF ANTI-HLA ANTIBODIES IN HEART TRANSPLANTATION

1991 • 198 citations

Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists

1994 • 195 citations

Identifying Strategies for Immune Intervention

1993 • 194 citations

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

1991 • 165 citations

Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat.

1992 • 163 citations

SOLUBLE HLA ANTIGENS, ANTI-HLA ANTIBODIES, AND ANTIIDIOTYPIC ANTIBODIES IN THE CIRCULATION OF RENAL TRANSPLANT RECIPIENTS

1991 • 162 citations

T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.

1991 • 138 citations

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 • 123 citations

Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone.

1992 • 114 citations

The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86

1993 • 107 citations

Antibody conjugates mimic specific B cell presentation of antigen: relationship between T and B cell specificity.

1987 • 103 citations

Dominance of one T-cell receptor in the H–2Kb/TNP response

1987 • 98 citations

T cell recognition of allo-peptides in context of syngeneic MHC

1991 • 98 citations

Antigen uptake and presentation by dendritic leukocytes.

1992 • 96 citations

Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides.

1990 • 91 citations

MEDIATION OF ACUTE BUT NOT CHRONIC REJECTION OF MHC-INCOMPATIBLE RAT KIDNEY GRAFTS BY ALLOREACTIVE CD4 T CELLS ACTIVATED BY THE DIRECT PATHWAY OF SENSITIZATION

1993 • 89 citations

Processed MHC class I alloantigen as the stimulus for CD4+ T-cell dependent antibody-mediated graft rejection

1992 • 89 citations

Limited T cell response to donor MHC peptides during allograft rejection. Implications for selective immune therapy in transplantation.

1994 • 85 citations

T cell recognition of allopeptides in context of syngeneic MHC.

1992 • 78 citations

Immunodominance: intramolecular competition between T cell epitopes.

1991 • 77 citations

THE INDIRECT PATHWAY OF ALLORECOGNITION

1995 • 74 citations

Allorecognition of isolated, denatured chains of class I and class II major histocompatibility complex molecules. Evidence for an important role for indirect allorecognition in transplantation

1992 • 66 citations

Limited usage of T cell receptor V beta genes by allopeptide-specific T cells.

1993 • 63 citations

Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells.

1991 • 60 citations

Indirect T cell allorecognition: a cyclosporin A resistant pathway for T cell help for antibody production to donor MHC antigens

1993 • 57 citations

Preferential pairing of T-B specificities in the same antigen: the concept of directional help

1988 • 56 citations

Lymphocytes infiltrating rat cardiac allografts express a limited repertoire of T cell receptor V beta genes.

1993 • 55 citations

Selective immunosuppression by administration of major histocompatibility complex (MHC) class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation.

1992 • 43 citations

T cell recognition of self-human histocompatibility leukocyte antigens (HLA)-DR peptides in context of syngeneic HLA-DR molecules.

1992 • 41 citations

EVIDENCE FOR DIRECT AND INDIRECT PATHWAYS IN THE GENERATION OF THE ALLOIMMUNE RESPONSE AGAINST PANCREATIC ISLETS

1991 • 38 citations

POSSIBLE INVOLVEMENT OF ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY

1990 • 37 citations

The late results of renal transplantation and the importance of chronic rejection as a cause of graft loss.

1989 • 36 citations

Naturally processed HLA class I bound peptides from c-myc-transfected cells reveal allele-specific motifs.

1993 • 31 citations

MHC class II binding of peptides derived from HLA-DR 1.

1992 • 30 citations

T CELL RECEPTOR Vβ GENE USAGE IN HLA-DR1-REACTIVE HUMAN T CELL POPULATIONS

1992 • 27 citations

Peptide binding to soluble HLA-DR4 molecules produced by insect cells.

1992 • 23 citations

REVERSAL OF DIABETES BY HUMAN FETAL PANCREAS

1991 • 22 citations

ENHANCED PRODUCTION OF INTERFERON-γ BY T LYMPHOCYTES CLONED FROM REJECTED KIDNEY GRAFTS

1991 • 20 citations

ENDOMYOCARDIAL BIOPSIES AFTER HEART TRANSPLANTATION

1993 • 19 citations

Antigen‐processing organelles from DRB1*1101 and DRB1*1104 B cell lines display a differential degradation activity

1995 • 16 citations

Current status of renal transplantation.

1990 • 12 citations

Registry report: International Society for Heart and Lung Transplantation.

1991 • 9 citations

Analysis of T Lymphocytes Cloned from Rejected Kidney Allograft: High Frequency of Cytotoxic T Cell Precursor

1988 • 1 citations