Expression of PDGF receptors and ligand-induced migration of partially differentiated human monocyte-derived macrophages Influence of IFN-γ and TGF-β

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

Signal transduction via platelet-derived growth factor receptors

1998 • 735 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Interferon-γ elicits arteriosclerosis in the absence of leukocytes

2000 • 375 citations

Structural and functional studies on platelet-derived growth factor.

1992 • 335 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

1988 • 314 citations

Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

1985 • 286 citations

Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.

1990 • 263 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

Platelet-derived growth factor gene expression in human atherosclerotic plaques and normal artery wall.

1988 • 245 citations

Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds.

1995 • 227 citations

Platelet‐derived Growth Factor

1995 • 200 citations

Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.

1992 • 179 citations

Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor

1989 • 179 citations

Cell-mediated immunity in atherosclerosis

1997 • 172 citations

Signalling mechanisms in the regulation of vascular cell migration

1995 • 170 citations

Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells

1992 • 119 citations

Thrombosis and atherosclerosis

1997 • 118 citations

Transforming growth factor-β1 regulates platelet-derived growth factor receptor β subunit in human liver fat-storing cells

1995 • 99 citations

Mechanism of action of platelet-derived growth factor

1996 • 99 citations

IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-gamma-activated site and a GC-rich element.

1998 • 91 citations

Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases

1999 • 73 citations

Differing signal transductions elicited by three isoforms of platelet-derived growth factor in vascular smooth muscle cells.

1993 • 69 citations

Heparan Sulfate Proteoglycans Mediate a Potent Inhibitory Signal for Migration of Vascular Smooth Muscle Cells

1998 • 68 citations

Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function.

1993 • 65 citations

Characterization of the retention motif in the C-terminal part of the long splice form of platelet-derived growth factor A-chain.

1994 • 59 citations

Transforming growth factor beta 1 downregulates the platelet-derived growth factor alpha-receptor subtype on human lung fibroblasts in vitro.

1995 • 56 citations

Dimerization of extracellular domains of platelet-derived growth factor receptors. A revised model of receptor-ligand interaction

1993 • 55 citations

Alternative Splicing Determines the Binding of Platelet-Derived Growth Factor (PDGF-AA) to Glycosaminoglycans

1996 • 55 citations

Structural Determinants in the Platelet-derived Growth Factor α-Receptor Implicated in Modulation of Chemotaxis

1996 • 53 citations

Migratory and proliferative effect of platelet‐derived growth factor in rabbit retinal endothelial cells: Evidence of an autocrine pathway of platelet‐derived growth factor

1994 • 52 citations

Regulation of differential expression of platelet-derived growth factor α- and β-receptor mRNA in normal and malignant human mesothelial cell lines

1996 • 39 citations

Platelet-Derived Growth Factor β-Receptors Can Both Promote and Inhibit Chemotaxis in Human Vascular Smooth Muscle Cells

1997 • 37 citations

Density‐dependent inhibitory effect of transforming growth factor‐β on human fibroblasts involves the down‐regulation of platelet‐derived growth factor α‐receptors

1993 • 36 citations

Maximal PDGF-induced lung fibroblast chemotaxis requires PDGF receptor-alpha

1996 • 33 citations

Different Effects of Basic Fibroblast Growth Factor and Transforming Growth Factor-β on the Two Platelet-Derived Growth Factor Receptors' Expression in Scleroderma and Healthy Human Dermal Fibroblasts

1995 • 32 citations

Processing of PDGF gene products determines interactions with glycosaminoglycans

1999 • 26 citations

Receptor binding of PDGF‐AA and PDGF‐BB, and the modulation of PDGF receptors by TGF‐β, in human periodontal ligament cells

1995 • 25 citations

Excess early signaling activity inhibits cellular chemotaxis toward PDGF-BB.

1994 • 25 citations

Scavenging, signalling and adhesion coupling in macrophages: implications for atherogenesis

1997 • 24 citations

Effects of Platelet-Derived Growth Factor on the Synthesis of Lipoprotein Lipase in Human Monocyte–Derived Macrophages

1995 • 23 citations

CONFIRMATION OF ALTERNATIVELY SPLICED PLATELET-DERIVED GROWTH FACTOR-A CHAIN AND CORRELATION WITH EXPRESSION OF PDGF RECEPTOR-α IN HUMAN CARDIAC ALLOGRAFTS1,2

1995 • 23 citations

Effect of Phenotype on the Transcription of the Genes for Platelet-Derived Growth Factor (PDGF) Isoforms in Human Smooth Muscle Cells, Monocyte-Derived Macrophages, and Endothelial Cells In Vitro

1997 • 21 citations

Platelet-derived growth factor is not chemotactic for human peripheral blood monocytes

1989 • 21 citations

Modification of macrophage function and effects on atherosclerosis

1996 • 18 citations

Quantitation of Platelet-Derived Growth Factor Receptors in Human Arterial Smooth Muscle Cells In Vitro

1997 • 16 citations