A PCR-based method for detection and quantification of small RNAs

MicroRNAs

2004 • 33,206 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Real-time quantification of microRNAs by stem-loop RT-PCR

2005 • 4,707 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

Identification of Tissue-Specific MicroRNAs from Mouse

2002 • 3,236 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

2004 • 2,341 citations

A pancreatic islet-specific microRNA regulates insulin secretion

2004 • 2,054 citations

A germline-specific class of small RNAs binds mammalian Piwi proteins

2006 • 1,629 citations

A novel class of small RNAs bind to MILI protein in mouse testes

2006 • 1,439 citations

Human embryonic stem cells express a unique set of microRNAs

2004 • 960 citations

A novel class of small RNAs in mouse spermatogenic cells

2006 • 827 citations

Microarray analysis of microRNA expression in the developing mammalian brain

2004 • 784 citations

Characterization of the piRNA Complex from Rat Testes

2006 • 728 citations

let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells

2006 • 612 citations

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

2003 • 574 citations

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

2006 • 553 citations

A high-throughput method to monitor the expression of microRNA precursors

2004 • 475 citations

Approaches to microRNA discovery

2006 • 463 citations

Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs

2005 • 424 citations

Numerous microRNPs in neuronal cells containing novel microRNAs

2003 • 378 citations

RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse

2001 • 321 citations

MicroRNA Mirn122a Reduces Expression of the Posttranscriptionally Regulated Germ Cell Transition Protein 2 (Tnp2) Messenger RNA (mRNA) by mRNA Cleavage1

2005 • 227 citations

Detection of single DNA base differences by competitive oligonucleotide priming

1989 • 178 citations

Reciprocal expression of lin‐41 and the microRNAs let‐7 and mir‐125 during mouse embryogenesis

2005 • 173 citations

Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells

2004 • 154 citations

The Expression of the let-7 Small Regulatory RNA Is Controlled by Ecdysone during Metamorphosis in Drosophila melanogaster

2002 • 144 citations

The expanding transcriptome: the genome as the ‘Book of Sand’

2006 • 86 citations

Proofreading DNA: recognition of aberrant DNA termini by the Klenow fragment of DNA polymerase I.

1994 • 70 citations

Polymerase chain reaction (PCR) mutagenesis enabling rapid non‐radioactive detection of common β‐thalassaemia mutations in Mediterraneans

1991 • 63 citations

Reverse transcriptase template switching during reverse transcriptase–polymerase chain reaction: Artificial generation of deletions in ribonucleotide reductase mRNA

2001 • 53 citations

Analysis of mRNA Transcripts from the NAD(P)H Oxidase 1 (Nox1) Gene

2004 • 44 citations

Reverse Transcription Slippage over the mRNA Secondary Structure of the LIP1 Gene

2001 • 37 citations

Cellular Dynamics of Small RNAs

2006 • 32 citations

Evaluation of 15 Polymerases and Phosphorothioate Primer Modification for Detection of UV-induced C:G to T:A Mutations by Allele-specific PCR¶

2004 • 18 citations

Template switching within exons 3 and 4 of KV11.1 (HERG) gives rise to a 5′ truncated cDNA

2006 • 5 citations