Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Experiments in molecular genetics

1972 • 28,260 citations

Laboratory course manual for methods in yeast genetics

1986 • 1,310 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

A workbench for multiple alignment construction and analysis

1991 • 1,005 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes

1992 • 707 citations

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

1993 • 668 citations

Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site

1983 • 667 citations

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

1992 • 613 citations

Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription

1992 • 596 citations

Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators

1993 • 589 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure.

1992 • 535 citations

Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae

1984 • 501 citations

Nucleosome loss activates yeast downstream promoters in vivo

1988 • 456 citations

Ion-exchange chromatography of nucleotides on poly-(ethyleneimine)-cellulose thin layers

1964 • 433 citations

Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB

1993 • 418 citations

A multisubunit complex containing the SWI1/ADR6,SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated fromyeast.

1994 • 396 citations

Initiation of Transcription by RNA Polymerase II: A Multi-step Process

1993 • 390 citations

DNA topoisomerase I is involved in both repression and activation of transcription

1993 • 380 citations

Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription

1992 • 379 citations

Yeast histone H4 N-terminal sequence is required for promoter activation in vivo

1991 • 330 citations

Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene Promoter

1988 • 320 citations

Family of proteins that interact with TFIID and regulate promoter activity

1991 • 319 citations

Activation of class II gene transcription by regulatory factors is potentiated by a novel activity

1991 • 318 citations

The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation.

1993 • 299 citations

Internal protein sequence analysis: Enzymatic digestion for less than 10 μg of protein bound to polyvinylidene difluoride or nitrocellulose membranes

1992 • 290 citations

The relationship between the "TATA" sequence and transcription initiation sites at the HIS4 gene of Saccharomyces cerevisiae.

1985 • 265 citations

Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP.

1988 • 263 citations

Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.

1990 • 255 citations

The yeast STE12 protein binds to the DNA sequence mediating pheromone induction.

1989 • 245 citations

Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation.

1991 • 244 citations

Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH.

1992 • 230 citations

Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome.

1992 • 218 citations

Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2.

1994 • 202 citations

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.

1994 • 199 citations

Nucleosome Core Displacement in Vitro via a Metastable Transcription Factor-Nucleosome Complex

1992 • 198 citations

A yeast TFIIB-related factor involved in RNA polymerase III transcription.

1992 • 181 citations

An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family.

1992 • 173 citations

A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae.

1992 • 168 citations

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

1993 • 167 citations

Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast.

1981 • 165 citations

Two components of Saccharomyces cerevisiae transcription factor IIIB (TFIIIB) are stereospecifically located upstream of a tRNA gene and interact with the second-largest subunit of TFIIIC.

1991 • 160 citations

Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus

1991 • 159 citations

Yeast SNF2/SWI2, SNF5, and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid.

1992 • 157 citations

An ATP-dependent inhibitor of TBP binding to DNA.

1993 • 156 citations

Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position.

1990 • 150 citations

Identification of a minimal set of proteins that is sufficient for accurate initiation of transcription by RNA polymerase II.

1993 • 148 citations

Isolation of Two Genes That Encode Subunits of the Yeast Transcription Factor IIA

1992 • 137 citations

Factors Involved in Specific Transcription by Mammalian RNA Polymerase II: Purification and Analysis of Transcription Factor ILA and Identification of Transcription Factor IIJ

1992 • 136 citations

Assembly and disassembly of the Drosophila RNA polymerase II complex during transcription.

1990 • 134 citations

An expanding family of helicases within the “DEAD/H” superfamily

1993 • 128 citations

Pheromone Response Elements Are Necessary and Sufficient for Basal and Pheromone-Induced Transcription of the FUS1 Gene of Saccharomyces cerevisiae

1991 • 126 citations

Reconstitution of transcription with five purified initiation factors and RNA polymerase II from Saccharomyces cerevisiae

1992 • 121 citations

Threshold Phenomena and Long-Distance Activation of Transcription by RNA Polymerase II

1992 • 118 citations

Molecular cloning of Drosophila TFIID subunits

1994 • 114 citations

CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters.

1993 • 109 citations

Molecular cloning of RAD16, a gene involved in differential repair inSaccharomyces cerevisiae

1992 • 108 citations

Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeastS.cerevisiae

1992 • 98 citations

A highly conserved domain of TFIID displays species specificity in vivo

1991 • 97 citations

The SNF2, SNF5 and SNF6 genes are required for Ty transcription in Saccharomyces cerevisiae.

1991 • 97 citations

Regulation of RNA polymerase II transcription

1993 • 97 citations

Induction of the yeast α-specific STE3 gene by the peptide pheromone a-factor

1984 • 97 citations

Sequence of RAD54, a Saccharomyces cerevisiae gene involved in recombination and repair

1991 • 94 citations

Architecture of a yeast U6 RNA gene promoter.

1993 • 93 citations

Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor

1992 • 92 citations

Immunopurification of yeast TATA-binding protein and associated factors. Presence of transcription factor IIIB transcriptional activity

1993 • 88 citations

Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein.

1991 • 85 citations

Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box-containing and TATA-less genes.

1994 • 81 citations

Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA.

1989 • 79 citations

Two distinct domains in the yeast transcription factor IID and evidence for a TATA box-induced conformational change.

1991 • 73 citations

Signal-mediated import of bacteriophage T7 RNA polymerase into the Saccharomyces cerevisiae nucleus and specific transcription of target genes.

1990 • 72 citations

Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau).

1992 • 64 citations

Transcriptional activator components and poxvirus DNA-dependent ATPases comprise a single family

1993 • 48 citations

The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene related to Drosophila and yeast transcriptional regulator genes

1992 • 44 citations

Isolation and characterization of the SUD1 gene, which encodes a global repressor of core promoter activity in Saccharomyces cerevisiae

1993 • 31 citations

TSF1 to TSF6, required for silencing the Saccharomyces cerevisiae GAL genes, are global regulatory genes.

1993 • 29 citations

Control of DNA synthesis genes in budding yeast: involvement of the transcriptional modulatorMOT1 in the expression of the DNA polymerase α gene

1992 • 24 citations