Inhibition of lignocaine metabolism by β-adrenoceptor antagonists in rat and human liver microsomes

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1951 • 319,299 citations

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The Carbon Monoxide-binding Pigment of Liver Microsomes

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An investigation of the comparative liposolubilities of β-adrenoceptor blocking agents

1981 • 177 citations

Biphasic Decrease of Radioactive Hemoprotein from Liver Microsomal CO-binding Particles

1969 • 105 citations

Inhibition of antipyrine metabolism by beta‐adrenoceptor antagonists.

1981 • 87 citations

Lidocaine elimination: Effects of metoprolol and of propranolol

1983 • 78 citations

Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man

1984 • 77 citations

The absorption of β-adrenoceptor antagonists in rat in-situ small intestine; the effect of lipophilicity

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Correlation of biological activity and high-pressure liquid chromatographic retention index for a series of propranolol, barbiturate, and anthranilic acid analogs

1979 • 47 citations

The inhibitory effect of propranolol pretreatment on its own metabolism in the rat.

1981 • 45 citations

Biological fate of butylated hydroxytoluene (BHT); Binding in vitro of BHT to liver microsomes.

1979 • 43 citations

Irreversible binding and metabolism of propranolol by human liver microsomes—Relationship to polymorphic oxidation

1987 • 42 citations

Evidence for Two Catalytically Different Binding Sites of Liver Microsomal Cytochrome P‐450: Importance for Species and Sex Differences in Oxidation Pattern of Lidocaine

1977 • 40 citations

Effects of beta‐adrenoceptor antagonists on the pharmacokinetics of lignocaine.

1984 • 37 citations

S-(N-methylcarbamoyl)-N-acetylcysteine: A urinary metabolite of the hepatotoxic experimental antitumour agent N-methylformamide (NSC 3051) in mouse, rat and man

1986 • 36 citations

Metabolism of Lidocaine in Human Liver in Vitro

1980 • 30 citations

Relationship between difference spectra and metabolism

1970 • 28 citations

Biphasic decrease of radioactive hemoprotein from liver microsomal carbon monoxide-binding particles. Effect of phenobarbital and chlordane.

1969 • 26 citations

Precursor–Metabolite Interaction in the Metabolism of Lidocaine

1984 • 25 citations

Lack of effect of atenolol on antipyrine clearance.

1982 • 20 citations

Pharmacokinetics and dynamics of penbutolol in humans: Evidence for pathway-specific stereoselective clearance

1986 • 19 citations

Kinetics and Biotransformation of Adrenergic Inhibitors

1981 • 15 citations

Interaction of a series of β-adrenergic blocking drugs with rat hepatic microsomal monooxygenase

1979 • 13 citations

Lung Accumulation of Some β-Adrenoceptor Antagonists

1978 • 12 citations

Penbutolol and propranolol: a comparison of their effects on antipyrine clearance in man.

1985 • 11 citations

The inhibition of rat hepatic microsomal propranolol metabolism by a covalently bound reactive metabolite.

1980 • 9 citations

Effect of penbutolol on lidocaine kinetics.

1983 • 7 citations

Distribution of β-Adrenoceptor Blocking Drugs into Cerebrospinal Fluid in Rats

1986 • 6 citations