Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by Phenytoin

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 • 805 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

1999 • 537 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital

2002 • 455 citations

The Importance of Drug Interactions in Epilepsy Therapy

2002 • 451 citations

Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes

2003 • 399 citations

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

2001 • 355 citations

Induction of CYP2C genes in human hepatocytes in primary culture.

2001 • 316 citations

Interactions between antiepileptic and chemotherapeutic drugs

2003 • 249 citations

Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products

2003 • 248 citations

Dexamethasone Enhances Constitutive Androstane Receptor Expression in Human Hepatocytes: Consequences on Cytochrome P450 Gene Regulation

2000 • 246 citations

Clinical Importance of Hepatic Cytochrome P450 in Drug Metabolism

1995 • 236 citations

The Course of Seizure Disorders in Patients With Malignant Gliomas

1995 • 225 citations

A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression

2003 • 208 citations

Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite.

1996 • 197 citations

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.

1997 • 195 citations

Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

2001 • 184 citations

Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells

2003 • 181 citations

Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia

2000 • 178 citations

REGULATION OF CYP2B6 IN PRIMARY HUMAN HEPATOCYTES BY PROTOTYPICAL INDUCERS

2004 • 176 citations

[42] Use of human hepatocytes to study P450 gene induction

1996 • 171 citations

The use of adult human hepatocytes in primary culture and other in vitro systems to investigate drug metabolism in man

1996 • 157 citations

Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction

1997 • 146 citations

The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver

2001 • 146 citations

Phenobarbital-Elicited Activation of Nuclear Receptor CAR in Induction of Cytochrome P450 Genes

2000 • 117 citations

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

2000 • 95 citations

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

2001 • 88 citations

Nuclear Receptor CAR as a Regulatory Factor for the Sexually Dimorphic Induction ofCYP2B1Gene by Phenobarbital in Rat Livers

2001 • 83 citations

Glucocorticoid Receptor Enhancement of Pregnane X Receptor-Mediated CYP2B6 Regulation in Primary Human Hepatocytes

2003 • 83 citations

Modulation of Mouse and Human Phenobarbital-Responsive Enhancer Module by Nuclear Receptors

2002 • 78 citations

Antiepileptic Drug Intoxication: Factors and Their Significance

1991 • 67 citations

Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR

2003 • 63 citations

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

2001 • 46 citations

Enantioselective induction of cyclophosphamide metabolism by phenytoin

1999 • 40 citations

Phenytoin-induced alteration in the N -dechloroethylation of ifosfamide stereoisomers

1997 • 35 citations

Residue Threonine 350 Confers Steroid Hormone Responsiveness to the Mouse Nuclear Orphan Receptor CAR

2002 • 22 citations

Ticlopidine-Induced Phenytoin Toxicity

1998 • 21 citations

Direct expression of fluorescent protein-tagged nuclear receptor CAR in mouse liver

2002 • 16 citations