Polarized Th2 cytokine expression by both mucosal γδ and αβ T cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

The mucosal immune system: from fundamental concepts to vaccine development

1992 • 912 citations

The common mucosal immune system and current strategies for induction of immune responses in external secretions

1987 • 810 citations

Immune interferon: a pleiotropic lymphokine with multiple effects

1985 • 676 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells.

1989 • 444 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.

1988 • 242 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

1992 • 186 citations

Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.

1990 • 183 citations

Construction of recombinant RNA templates for use as internal standards in quantitative RT-PCR.

1993 • 180 citations

Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin

1994 • 119 citations

Selective induction of Th2 cells in murine Peyer's patches by oral immunization

1992 • 118 citations

The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations.

1988 • 105 citations

Distribution, persistence, and recall of serum and salivary antibody responses to peroral immunization with protein antigen I/II of Streptococcus mutans coupled to the cholera toxin B subunit

1991 • 102 citations

Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues.

1992 • 98 citations

Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.

1993 • 93 citations

Mucosal and systemic immune responses in BALB/c mice to Bacteroides gingivalis fimbriae administered orally

1989 • 74 citations

Interleukin 5 is a differentiation factor for IgA B cells

1989 • 73 citations

Distinction of mouse CD8+ suppressor effector T cell clones from cytotoxic T cell clones by cytokine production and CD45 isoforms.

1993 • 73 citations

Function of αβ TCR⁺ intestinal intraepithelial lymphocytes: T_h1-and T_h2-type cytokine production by CD4⁺ CD8⁻ and CD4⁺ CD8⁺ T cells for helper activity

1993 • 68 citations

Interleukin-5 induces maturation but not class switching of surface IgA-positive B cells into IgA-secreting cells.

1989 • 63 citations

Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.

1993 • 62 citations

Regulation of mucosal responses by CD4⁺ T lymphocytes: effects of anti-L3T4 treatment on the gastrointestinal immune system

1991 • 41 citations

Regulation of the IgM and IgA anti-dextran B1355S response: synergy between IFN-gamma, BCGF II, and IL 2.

1985 • 37 citations

Increase of precursor frequency and clonal size of murine IgE-secreting cells by IL-4.

1988 • 36 citations

The cellular basis of salivary immunity in the mouse: Incidence and distribution of B cells, T cells and macrophages in single‐cell suspensions of the major salivary glands

1986 • 31 citations

Characterization of cytokine‐producing cells in mucosal effector sites: CD3⁺ T cells of Th1 and Th2 type in salivary gland‐associated tissues

1994 • 30 citations

Secretory immune responses in ageing rats. II. Phenotype distribution of lymphocytes in secretory and lymphoid tissues.

1988 • 30 citations

Phenotype of mononuclear leucocytes resident in rat major salivary and lacrimal glands.

1988 • 27 citations

Quantitative Measurement of Human T-Cell Receptor Vβ Subfamilies by Reverse Transcription-Polymerase Chain Reaction Using Synthetic Internal mRNA Standards

1993 • 21 citations