Dexfenfluramine

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Impact of Informing Overweight Individuals about the Role of Genetics in Obesity: An Online Experimental Study

2013 • 5,797 citations

Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991

1994 • 2,623 citations

Waist circumference as a measure for indicating need for weight management

1995 • 1,846 citations

An Adoption Study of Human Obesity

1986 • 1,308 citations

The Body-Mass Index of Twins Who Have Been Reared Apart

1990 • 1,283 citations

Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

1996 • 1,131 citations

Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis

1992 • 1,077 citations

Waist circumference action levels in the identification of cardiovascular risk factors: prevalence study in a random sample

1995 • 1,009 citations

Serotonin and appetite

1984 • 579 citations

Limitations in the assessment of dietary energy intake by self-report

1995 • 480 citations

Measurements of total energy expenditure provide insights into the validity of dietary measurements of energy intake

1993 • 414 citations

INTERNATIONAL TRIAL OF LONG-TERM DEXFENFLURAMINE IN OBESITY

1989 • 315 citations

Continuous infusion of glucose with model assessment: measurement of insulin resistance and ?-cell function in man

1985 • 288 citations

A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors

1992 • 279 citations

Primary pulmonary hypertension and fenfluramine use.

1993 • 245 citations

Genetics of obesity in adult adoptees and their biological siblings.

1989 • 240 citations

The Cost of Obesity

1994 • 205 citations

Obesity in Europe

1994 • 201 citations

Current views on obesity

1996 • 196 citations

Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system

1986 • 191 citations

Use and Abuse of Appetite-Suppressant Drugs in the Treatment of Obesity

1993 • 183 citations

Appetite Suppressants

1992 • 183 citations

Pulmonary hypertension and fenfluramine

1981 • 169 citations

Serotonin and the biology of feeding

1992 • 151 citations

Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers

1993 • 144 citations

D-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects

1985 • 127 citations

Prevalence of obesity: a comparative survey in France, the United Kingdom and the United States.

1992 • 118 citations

Dexfenfluramine

1992 • 113 citations

Neurochemical Mechanism of Action of Anorectic Drugs

1993 • 112 citations

Very low-calorie diets. National Task Force on the Prevention and Treatment of Obesity, National Institutes of Health

1993 • 110 citations

Long-term weight loss: the effect of pharmacologic agents

1994 • 100 citations

The Cost of Obesity

1994 • 95 citations

Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective.

1991 • 89 citations

Dexfenfluramine and serotonin neurotoxicity: further preclinical evidence that clinical caution is indicated.

1994 • 87 citations

d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors

1993 • 82 citations

Pulmonary hypertension and dexfenfluramine

1992 • 76 citations

Dexfenfluramine neurotoxicity in brains of non-human primates

1991 • 75 citations

Regulation of nutrient metabolism and energy expenditure

1995 • 73 citations

Neuroendocrine abnormalities in human obesity

1995 • 71 citations

Species differences in the kinetics and metabolism of fenfluramine isomers.

1982 • 68 citations

Improvement of Insulin-Induced Glucose Disposal in Obese Patients With NIDDM After 1-Wk Treatment With d-Fenfluramine

1991 • 68 citations

Pulmonary hypertension and fenfluramine

1990 • 60 citations

Comparison of an ephedrine/caffeine combination and dexfenfluramine in the treatment of obesity. A double-blind multi-centre trial in general practice.

1994 • 57 citations

Role of 5-HT receptors in the effect of d-fenfluramine on feeding patterns in the rat

1992 • 57 citations

Carbohydrate craving, mood changes, and obesity.

1988 • 55 citations

d-Fenfluramine selectively decreases carbohydrate but not protein intake in obese subjects.

1984 • 53 citations

The International Primary Pulmonary Hypertension Study (IPPHS)

1994 • 51 citations

Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d- and dl-fenfluramine for 15 days

1985 • 50 citations

The pharmacokinetics of dexfenfluramine in obese and non-obese subjects.

1995 • 49 citations

Dexfenfluramine treatment of obesity: a double blind trial with post trial follow up.

1995 • 49 citations

Dexfenfluramine in the treatment of severe obesity: a placebo‐controlled investigation of the effects on weight loss, cardiovascular risk factors, food intake and eating behaviour

1992 • 48 citations

Report on the NIH Workshop on Pharmacologic Treatment of Obesity

1994 • 48 citations

In vitro and in vivo effects of d-fenfluramine: no apparent relation between 5-hydroxytryptamine release and hypophagia.

1995 • 47 citations

Serotonin and dietary fat intake: Effects of dexfenfluramine

1995 • 47 citations

The Effects of Dexfenfluramine on Blood Glucose Control in Patients with Type 2 Diabetes

1992 • 46 citations

Dexfenfluramine, Fluoxetine, and Weight Loss Among Female Carbohydrate Cravers

1993 • 44 citations

The 5-HT1B receptor mediates the effect of d-fenfluramine on eating caused by intra-hypothalamic injection of neuropeptide Y

1995 • 43 citations

Reduction of Visceral Adipose Tissue and Improvement of Metabolic Indices: Effect of Dexfenfluramine in NIDDM

1996 • 41 citations

Comparison of Medically Supervised and Unsupervised Approaches to Weight Loss and Control

1993 • 39 citations

Worldwide Epidemiology of Obesity

1994 • 39 citations

Progress report on the anorectic effects of dexfenfluramine, fluoxetine and sertraline.

1992 • 39 citations

Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets

1988 • 39 citations

Effects of dexfenfluramine treatment on body weight and postprandial thermogenesis in obese subjects. A double-blind placebo-controlled study.

1993 • 39 citations

d-fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release

1994 • 38 citations

Familial resemblance in fatness indicators

1983 • 38 citations

Effect of dexfenfluramine treatment on body weight, blood pressure and noradrenergic activity in obese hypertensive patients

1992 • 37 citations

Dexfenfluramine in Type II diabetes: effect on weight and diabetes control

1993 • 36 citations

The Comparison of Four Weight Reduction Strategies Aimed at Overweight Diabetic Patients

1995 • 35 citations

Socioeconomic Consequences of Obesity

1994 • 35 citations

Long-term changes of body weight and cardiovascular risk factors after weight reduction with group therapy and dexfenfluramine.

1994 • 33 citations

Haemodynamic, metabolic and endocrine effects of short-term dexfenfluramine treatment in young, obese women

1991 • 31 citations

The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine

1996 • 30 citations

Obese Patients with Type 2 Diabetes Poorly Controlled by Insulin and Metformin: Effects of Adjunctive Dexfenfluramine Therapy on Glycaemic Control

1994 • 29 citations

Chronic D-fenfluramine decreases serotonin transporter messenger RNA expression in dorsal raphe nucleus

1994 • 28 citations

Appetite regulation by serotoninergic mechanisms and effects of d-fenfluramine.

1994 • 28 citations

Comparative biodisposition and metabolism of¹⁴C-(±)-fenfluramine in mouse, rat, dog and man

1992 • 28 citations

The acute effect of dexfenfluramine on resting metabolic rate and postprandial thermogenesis in obese subjects: a double-blind placebo-controlled study.

1993 • 28 citations

Guidelines for the Approval and Use of Drugs to Treat Obesity

1995 • 28 citations

Neuroendocrine regulation and obesity.

1992 • 28 citations

d-Fenfluramine in a rat model of dietary fat-induced obesity

1993 • 26 citations

Influence of short-term dexfenfluramine therapy on glucose and lipid metabolism in obese non-diabetic patients

1993 • 26 citations

Dexfenfluramine

1990 • 24 citations

Drug therapy after very-low-calorie diets

1992 • 23 citations

5-HT and carbohydrate suppression: Effects of 5-HT antagonists on the action of d-fenfluramine and DOI

1993 • 23 citations

Long-term effect of dexfenfluramine on amino acid profiles and food selection in obese patients during weight loss.

1996 • 21 citations

Body weight evolution during dexfenfluramine treatment after initial weight control.

1992 • 21 citations

Dexfenfluramine reduces cardiovascular risk factors.

1994 • 21 citations

Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms

1993 • 21 citations

Feeding pattern studies suggest that d-fenfluramine and sertraline specifically enhance the state of satiety in rats

1992 • 20 citations

Effect of escalating doses of d-fenfluramine on the content of indoles in brain

1992 • 20 citations

In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat

1996 • 19 citations

The Interactions of MK‐801 with the Amphetamine Analogues d‐Methamphetamine (d‐METH), 3,4‐Methylenedioxymethamphetamine (d‐MDMA) or d‐Fenfluramine (d‐FEN): Neural Damage and Neural Protection^a

1993 • 19 citations

Effect of dexfenfluramine on body weight, blood pressure, insulin resistance and serum cholesterol in obese individuals.

1995 • 18 citations

The effect of dexfenfluramine on eating habits in a Dutch ambulatory android overweight population with an overconsumption of snacks.

1995 • 18 citations

Changes in energy metabolism and metabolite patterns of obese rats after application of dexfenfluramine

1996 • 17 citations

Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies.

1992 • 17 citations

Dexfenfluramine and appetite in humans.

1992 • 17 citations

Effects of dexfenfluramine on free fatty acid turnover and oxidation in obese patients with type 2 diabetes mellitus

1995 • 17 citations

Oral kinetics of dexfenfluramine and dexnorfenfluramine in non-human primates

1995 • 16 citations

Psychological and metabolic effects of dietary carbohydrates and dexfenfluramine during a low-energy diet in obese women

1994 • 16 citations

Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR: LA‐corpulent rats treated with <scp>d</scp>‐fenfluramine

1992 • 16 citations

Effects of dexfenfluramine on resting metabolic rate and thermogenesis in premenopausal obese women during therapeutic weight reduction

1995 • 16 citations

Lipostatic and ischymetric mechanisms originate dexfenfluramine-induced anorexia

1988 • 14 citations

The Economics of Treating Obesity

1994 • 14 citations

Metabolic abnormalities linked to obesity: Effects of dexfenfluramine in the corpulent rat

1995 • 14 citations

Pharmacological aspects of obesity treatment: towards the 21st century.

1995 • 14 citations

Effects of dexfenfluramine of glucose turnover in non-insulin-dependent diabetes mellitus

1994 • 13 citations

Energy metabolism and metabolite patterns of rats after application of dexfenfluramine.

1994 • 13 citations

Management Strategies for Weight Control

1990 • 12 citations

Enhancement of the thermic effect of food by d-fenfluramine.

1988 • 12 citations

Obesity Drug Renews Toxicity Debate

1994 • 12 citations

Effect of dexfenfluramine on gastric emptying of a mixed solid-liquid meal in obese subjects

1990 • 11 citations

[A case of chronic pulmonary hypertension after fenfluramine intake].

1982 • 11 citations

Effects of chronic low doses of d-fenfluramine on weight gain and calorie intake, brown adipose tissue thermogenic parameters and brain neurotransmitter content in rats fed chow or palatable diets.

1989 • 10 citations

The influence of chronic administration of the serotonin agonist dexfenfluramine on responsiveness to corticotropin releasing hormone and growth hormone-releasing hormone in moderately obese people

1995 • 10 citations

Serotoninergic receptor activation by dextrofenfluramine enhances the blunted pituitary-adrenal responsiveness to corticotropin-releasing hormone in obese subjects

1992 • 10 citations

Effect of dexfenfluramine on energy expenditure in obese patients on a very-low-calorie-diet.

1995 • 9 citations

Options for the Management of Obesity

1994 • 9 citations

An update on the pharmacology of serotoninergic appetite-suppressive drugs.

1992 • 9 citations

Turnover and Oxidation Rates of Plasma-Free Fatty Acids in Obese Patients Treated with Dexfenfluramine

1993 • 9 citations

Endocrine and Metabolic Effects of Dexfenfluramine in Patients with Android Obesity

1993 • 9 citations

Repeated Administration of Escalating High Doses of Dexfenfluramine does not Produce Morphological Evidence for Neurotoxicity in the Cortex of Rats

1996 • 8 citations

Specific stimulation of brain serotonin mediated neurotransmission by dexfenfluramine does not restore growth hormone responsiveness in obese women

1996 • 8 citations

Epidemiological data on hyperinsulinaemia and vascular disease

1993 • 6 citations

TREATMENT OF OBESE PATIENTS WITH DEXFENFLURAMINE

1995 • 6 citations

The effect of withdrawal and re-introduction of dexfenfluramine in the treatment of obesity.

1996 • 5 citations

Introduction

1995 • 5 citations

Effect of dexfenfluramine on energy expenditure in man.

1992 • 4 citations

Effects of tianeptine on 5-HTP- and dextrofenfluramine-induced hypophagia in the rat

1993 • 4 citations

[Severe pulmonary hypertension complicating a long treatment with dexfenfluramine].

1994 • 2 citations