Exposure to Toxic Agents: The Heme Biosynthetic Pathway and Hemoproteins as Indicator

The Metabolic Basis of Inherited Disease.

1983 • 2,885 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Handbook of Experimental Pharmacology

1968 • 789 citations

Metals as Regulators of Heme Metabolism

1977 • 338 citations

The Toxicity of Polychlorinated Polycyclic Compounds and Related Chemicals

1973 • 310 citations

Acquired Toxic Porphyria Cutanea Tarda Due to Hexachlorobenzene

1963 • 286 citations

Methemoglobinemia: A Comprehensive Treatise

2019 • 285 citations

Acquired Porphyria in Man and Rat due to Hexachlorobenzene Intoxication

1961 • 232 citations

Zinc Protoporphyrin in the Erythrocytes of Patients with Lead Intoxication and Iron Deficiency Anemia

1974 • 232 citations

Porphyrins in Human Diseases.

1977 • 225 citations

Suicidal Destruction of Cytochrome P-450 During Oxidative Drug Metabolism

1983 • 223 citations

Cutaneous Porphyria in Turkey

1960 • 220 citations

Industrially Acquired Porphyria

1964 • 210 citations

Hexachlorobenzene (HCB): A review

1979 • 207 citations

Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct

1981 • 206 citations

Comparative toxicologic study with polychlorinated biphenyls in chickens with special reference to porphyria, edema formation, liver necrosis, and tissue residues

1970 • 184 citations

Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates.

1980 • 178 citations

Nervous and Biochemical Disturbances Following Hexachlorobenzene Intoxication

1961 • 177 citations

Polybrominated biphenyls (PBB) environmental contamination in Michigan, 1973–1976

1977 • 165 citations

N-Phenylprotoporphyrin IX formation in the hemoglobin-phenylhydrazine reaction. Evidence for a protein-stabilized iron-phenyl intermediate.

1982 • 153 citations

Mechanism of cytochrome P-450 inhibition by cyclopropylamines

1982 • 141 citations

2,3,7,8-Tetrachlorodibenzo- p -dioxin: A Potent Inducer of δ-Aminolevulinic Acid Synthetase

1973 • 140 citations

Macrocyclic intermediates in the biosynthesis of porphyrins

1976 • 139 citations

Studies on the toxicology of hexachlorobenzene

1976 • 139 citations

Zinc Protoporphyrin (ZPP): A Simple, Sensitive, Fluorometric Screening Test for Lead Poisioning

1975 • 133 citations

Suicidal inactivation of cytochrome P-450 by cyclopropylamines. Evidence for cation-radical intermediates

1982 • 122 citations

Chemical porphyria in man

1980 • 115 citations

The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450

1971 • 115 citations

Erythropoietic protoporphyria and lead intoxication: the molecular basis for difference in cutaneous photosensitivity. II. Different binding of erythrocyte protoporphyrin to hemoglobin.

1975 • 113 citations

Tin: A Potent Inducer of Heme Oxygenase in Kidney

1976 • 111 citations

N-Alkylprotoporphyrin IX formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the alkyl group from the substrate to the porphyrin.

1981 • 106 citations

Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct.

1981 • 102 citations

Destruction of cytochrome P-450 by ethylene and other olefins.

1980 • 102 citations

Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase

1979 • 99 citations

Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation

1982 • 98 citations

Evaluation of Erythrocyte δ-amino Levulinic Acid Dehydratase Activity as a Short-Term Indicator in Fish of a Harmful Exposure to Lead

1977 • 96 citations

Uroporphyrin formation induced by chlorinated hydrocarbons (lindane, polychlorinated biphenyls, tetrachlorodibenzo-p-dioxin). Requirements for endogenous iron, protein synthesis and drug-metabolizing activity

1974 • 96 citations

Experimental hepatic porphyria induced by polychlorinated biphenyls

1974 • 92 citations

Decreased liver cytochrome P-450 in rats caused by norethindrone or ethynyloestradiol

1977 • 91 citations

Self-catalyzed destruction of cytochrome P-450: covalent binding of ethynyl sterols to prosthetic heme.

1979 • 83 citations

Uroporphyrinogen decarboxylase. Purification, properties, and inhibition by polychlorinated biphenyl isomers.

1983 • 81 citations

Drug-induced porphyrin biosynthesis—V

1972 • 81 citations

Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct

1978 • 80 citations

Hepatic porphyria induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse.

1973 • 79 citations

Effects of Diethyl-1, 4-dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylate on the Metabolism of Porphyrins and Iron

1963 • 77 citations

The reaction of phenylhydrazine with microsomal cytochrome P-450. Catalysis of heme modification.

1982 • 77 citations

N-Methylprotoporphyrin IX: chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine treatment.

1981 • 74 citations

Experimental porphyria in rats induced by chlorinated benzenes

1963 • 73 citations

δ-Amino Levulinic Acid Dehydratase Activity of Fish Blood as an Indicator of a Harmful Exposure to Lead

1976 • 71 citations

Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448

1984 • 70 citations

Metabolic activation of acetylenic substituents to derivatives in the rat causing the loss of hepatic cytochrome P-450 and haem

1978 • 69 citations

Polychlorinated biphenyls as inducers of hepatic porphyria in Japanese quail, with special reference to ?-aminolevulinic acid synthetase activity, fluorescence, and residues in the liver

1971 • 68 citations

Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt

1979 • 68 citations

Evidence for the transcriptional inhibition by heme of the synthesis of δ-aminolevulinate synthase in rat liver

1982 • 68 citations

Effects of a polybrominated biphenyl mixture in the rat and mouse

1983 • 67 citations

Comparative toxicity study of 2,4,5,2?,4?,5?-hexachlorobiphenyl and a polychlorinated biphenyl mixture in rabbits

1972 • 67 citations

Porphyria Caused by Hexachlorobenzene and Other Polyhalogenated Aromatic Hydrocarbons

1978 • 66 citations

The regulation of heme synthesis related to drug metabolism.

1973 • 66 citations

Some kinetic properties of human red cell uroporphyrinogen decarboxylase

1980 • 66 citations

Response of hepatic microsomal mixed-function oxidases to various types of insecticide chemical synergists administered to mice

1971 • 66 citations

Renal porphyrinuria during chronic methyl mercury exposure.

1977 • 65 citations

Interactions among lead, cadmium, and arsenic in relation to porphyrin excretion patterns.

1978 • 64 citations

Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins

1981 • 64 citations

Studies on the toxicology of hexachlorobenzene

1978 • 63 citations

A comparative study of two polychlorinated biphenyl mixtures (Aroclors 1242 and 1016) containing 42% chlorine on induction of hepatic porphyria and drug metabolizing enzymes

1975 • 62 citations

Central Nervous System Dysfunction Due to Lead Exposure

1978 • 62 citations

Immunoreactive uroporphyrinogen decarboxylase is unchanged in porphyria caused by TCDD and hexachlorobenzene

1982 • 62 citations

Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria

1983 • 60 citations

Inhibition of protohaem ferro-lyase in experimental porphyria. Isolation and partial characterization of a modified porphyrin inhibitor

1980 • 58 citations

Inhibition by hemin of in vitro translocation of chicken liver δ-aminolevulinate synthase into mitochondria

1983 • 57 citations

In vitro inhibitory effect on porphyrinogen carboxylyase of liver extracts from tcdd treated mice

1984 • 56 citations

Altered regulation of hepatic heme metabolism by indium chloride

1979 • 53 citations

High-performance liquid chromatography of naturally occurring 8-, 7-, 6-, 5- and 4-carboxylic porphyrin isomers

1983 • 52 citations

Studies on the toxicology of hexachlorobenzene

1978 • 52 citations

Porphyria turcica. Twenty years after hexachlorobenzene intoxication

1980 • 52 citations

Identification of N-methylprotoporphyrin IX in livers of untreated mice and mice treated with 3,5-diethoxycarbonyl-1,4-dihydrocollidine: Source of the methyl group

1981 • 52 citations

beta-meso-Phenylbiliverdin IX alpha and N-phenylprotoporphyrin IX, products of the reaction of phenylhydrazine with oxyhemoproteins.

1981 • 50 citations

Liver production of N‐alkylated porphyrins caused in mice by treatment with substituted dihydropyridines

1981 • 50 citations

Sex differences in the metabolism of hexachlorobenzene by rats and the development of porphyria in females

1982 • 50 citations

Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism

1978 • 50 citations

Cyclopropylamines as suicide substrates for cytochromes P-450

1979 • 47 citations

HEXACHLOROBENZENEINDUCED FORPHYRIA EFFECT OF CHELATION ON THE DISEASE, PORPHYRIN AND METAL METABOLISM

1966 • 47 citations

Drug-induced conversion of liver haem into modified porphyrins. Evidence for two classes of products

1980 • 47 citations

Regulation of cytochrome P‐450‐dependent microsomal drug‐metabolizing enzymes by nickel, cobalt, and iron

1977 • 46 citations

Porphyrogenic effect of chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats. Dose-effect relationship following urinary excretion of porphyrins

1981 • 45 citations

A difference between two strains of rats in their liver non-haem iron content and in their response to the porphyrogenic effect of hexachlorobenzene

1979 • 44 citations

Hemoprotein destruction. Iron-nitrogen shift of a phenyl group in a porphyrin complex

1982 • 43 citations

Studies on the action of porphyrinogenic trace metals on the activity of hepatic uroporphyrinogen decarboxylase

1981 • 43 citations

Metabolism as a prerequisite for the porphyrinogenic action of polyhalogenated aromatics, with special reference to hexachlorobenzene and polybrominated biphenyls (Firemaster BP-6)

1980 • 43 citations

Drug Interactions in Experimental Hepatic Porphyria

1973 • 42 citations

Conversion of liver haem into N‐substituted porphyrins or green pigments

1980 • 42 citations

Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action

1977 • 39 citations

Second derivative-high-performance liquid chromatographic-fluorometric detection of porphyrins in chick embryo liver cell culture medium

1980 • 39 citations

PORPHYRIAS AND PORPHYRIN METABOLISM, WITH SPECIAL REFERENCE TO PORPHYRIA IN CHILDHOOD.

1964 • 39 citations

The inhibition of testicular heme oxygenase activity by cadmium. A novel cellular response.

1982 • 38 citations

Biotransformation and porphyrinogenic action of hexachlorobenzene and its metabolites in a primary liver cell culture

1981 • 38 citations

Induction of porphyrin synthesis in chick embryo liver cell culture by synthetic polychlorobiphenyl isomers

1978 • 38 citations

Effects of Administration of Cobalt Chloride and Cobalt Protoporphyrin on δ-Aminolevulinate Synthase in Rat Liver1

1978 • 36 citations

Studies of the relationship between chemical structure and porphyria-inducing activity

1965 • 36 citations

Selective inhibition of δ-aminolevulinic acid dehydratase by indium chloride in rat kidney: Biochemical and ultrastructural studies

1982 • 36 citations

Increased Liver Haem Degradation Caused by Foreign Chemicals: A Comparison of the Effects of 2-Allyl-2-isopropylacetamide and Cobaltous Chloride

1976 • 35 citations

Porphyria Turcica

1980 • 34 citations

Association between induction of aryl hydrocarbon hydroxylase and depression of uroporphyrinogen decarboxylase activity.

1977 • 34 citations

Selective activation of particulate guanylate cyclase by a specific class of porphyrins.

1984 • 33 citations

Effect of Cobalt on Heme Biosynthesis in Rat Liver and Spleen1

1975 • 31 citations

Effects of metals on heme biosynthesis and metabolism.

1978 • 30 citations

Studies on the toxicology of hexachlorobenzene

1983 • 30 citations

Porphyrias and Porphyrin Metabolism, with Special Reference to Porphyria in Childhood

1964 • 30 citations

Mechanism of the inhibitory action of phenelzine on microsomal drug metabolism.

1981 • 30 citations

Structural effects in alkyl nitrite oxidation of human hemoglobin.

1984 • 30 citations

Loss of Liver Cytochrome P-450 Caused by Chemicals

1978 • 28 citations

Chlorinated benzene induction of hepatic porphyria

1977 • 28 citations

ADVANCES IN PHARMACOLOGY AND THERAPEUTICS II

1982 • 27 citations

The effects of chemicals on hepatic heme biosynthesis

1981 • 27 citations

Alterations induced in heme pathway enzymes and monooxygenases by gold.

1978 • 27 citations

Drug-induced porphyrin biosynthesis—XIX

1979 • 26 citations

Formation of cobalt protoporphyrin by chicken hepatocytes in culture

1982 • 26 citations

Differential inhibition of erythrocyte and hepatic uroporphyrinogen 1 synthetase activity by lead

1974 • 25 citations

Prostacyclin Synthase, a Cytochrome P450 Enzyme

1983 • 25 citations

Ferrochelatase-inhibitory and porphyrin-inducing properties of 3,5-diethoxycarbonyl-1, 4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.

1981 • 24 citations

Maintenance of microsomal hemoprotein concentrations following inhibition of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydrocollidine in chick embryo liver.

1979 • 23 citations

Polychlorobiphenyls that induce δ‐aminolevulinic acid synthetase inhibit uroporphyrinogen decarboxylase in cultured chick embryo liver cells

1981 • 23 citations

Changes in Haem Synthesis Associated with Occupational Exposure to Organic and Inorganic Sulphides

1983 • 22 citations

Effect of cobalt on the synthesis and degradation of hepatic catalse in vivo

1974 • 22 citations

Lead Poisoning in an Art Conservator

1982 • 20 citations

Inhibition of uroporphyrinogen decarboxylase by 3,3′,4,4′-tetrachlorobiphenyl in chick embryo liver cell culture

1983 • 20 citations

Current status of neurotoxicology, basic and applied

1982 • 20 citations

The effect of cobaltous chloride on liver haem metabolism in the rat. Evidence for inhibition of haem synthesis and for increased haem degradation.

1976 • 19 citations

Identification of cobalt protoporphyrin IX formation in vivo following cobalt administration to rats

1980 • 19 citations

Patterns of porphyrin accumulation in response to chemicals in chick embryo liver cells

1983 • 17 citations

The effects of environmental lead exposure and in vitro zinc on tissue δ-aminolevulinic acid dehydratase in urban pigeons

1983 • 17 citations

Urinary uroporphyrin as an indicator of arsenic exposure in rats.

1983 • 17 citations

Salmonella typhi spondylitis: an unusual presentation.

1971 • 16 citations

Biotransformation of glyceryl trinitrate to glyceryl dinitrate by human hemoglobin

1984 • 16 citations

Heme metabolism in the fetoplacental unit and neonatal livers during lactation: effect of gold sodium thiomalate.

1980 • 15 citations

Coproporphyrinuria and chronic hepatic porphyria type A found in people frome Seveso (Italy) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1979 • 15 citations

Drug Induced Porphyrin Biosynthesis

1973 • 15 citations

DIAZINON AND PORPHYRIA CUTANEA TARDA

1979 • 14 citations

Alterations in the heme biosynthetic pathway as an index of exposure to toxins

1982 • 14 citations

Croporphyrinuria and chronic hepatic porphyria type A found in farm families from Michigan (USA) exposed to polybrominated biphenyls (PBB)

1979 • 13 citations

Comparison of the porphyrinogenic activity of hexabromobenzene and hexachlorobenzene in primiparous wistar rats

1979 • 12 citations

Separation of impurities in diazinon preparations and their effect on porphyrin biosynthesis in tissue culture

1982 • 11 citations

Brominated benzene induction of hepatic porphyria

1979 • 10 citations

Relative abilities on a molar basis of hexafluoro-, hexachloro- and hexabromobenzenes to decrease liver uroporphyrinogen decarboxylase activity and cause porphyria in female rats.

1980 • 10 citations

Studies on the porphyrinogenic action of 1,2,4-trichlorobenzene in birds

1983 • 7 citations

Porphyrinogen carboxy-lyase from chick embryo liver—in vivo effect of heptachlor and lindane

1980 • 7 citations

雌ラットにおけるヘキサフルオロ-,ヘキサクロロ-およびヘキサブロモ-ベンゼンの肝臓ウロポルフィリノーゲンデカルボキシラーゼ活性抑制およびポルフィリン症誘発のモル比による相対活性

1980 • 6 citations

The site of inhibition of porphyrin biosynthesis by an isomer of diazinon in rats

1983 • 5 citations

Why is the patient with lead intoxication not light sensitive?

1982 • 5 citations

[Toxic hepato-cutaneous porphyria (occupational disease)].

1975 • 4 citations

Toxic Effects of Metals on the Synthesis and Disposition of Heme

1982 • 2 citations

Deleted Work

1955 • 0 citations