Free Radicals, Cytokines, and Respiratory Muscles in COPD Patients

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Free radicals and tissue damage produced by exercise

1982 • 1,754 citations

Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis

2004 • 1,754 citations

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

2001 • 1,102 citations

Physiology of Nitric Oxide in Skeletal Muscle

2001 • 1,053 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Acute Inflammatory Responses in the Airways and Peripheral Blood After Short-Term Exposure to Diesel Exhaust in Healthy Human Volunteers

1999 • 875 citations

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

1996 • 727 citations

Cytokines Involved in the Systemic Inflammatory Response Induced by Exposure to Particulate Matter Air Pollutants (PM₁₀)

2001 • 665 citations

IL-6-induced skeletal muscle atrophy

2004 • 556 citations

Inflammatory cell response to acute muscle injury

1995 • 528 citations

Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.

1996 • 526 citations

Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro

1992 • 496 citations

Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease.

1994 • 487 citations

Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α

1998 • 486 citations

Contractile Properties of the Human Diaphragm during Chronic Hyperinflation

1991 • 450 citations

Histochemical and morphological characteristics of the vastus lateralis muscle in patients with chronic obstructive pulmonary disease

1998 • 442 citations

Pulmonary and Systemic Oxidant/Antioxidant Imbalance in Chronic Obstructive Pulmonary Disease

2005 • 402 citations

Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor‐κΒ

2001 • 400 citations

Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

1996 • 400 citations

Cellular Adaptations in the Diaphragm in Chronic Obstructive Pulmonary Disease

1997 • 383 citations

Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals

1983 • 318 citations

Respiratory and Limb Muscle Weakness Induced by Tumor Necrosis Factor-α

2002 • 315 citations

Exercise-induced Quadriceps Oxidative Stress and Peripheral Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

2003 • 257 citations

Microtubule dysfunction by posttranslational nitrotyrosination of α-tubulin: A nitric oxide-dependent mechanism of cellular injury

1999 • 255 citations

DNA Damage by Nitric Oxide

1996 • 248 citations

Physiological role of tumor necrosis factor α in traumatic muscle injury

2002 • 244 citations

Oxidative Stress and Respiratory Muscle Dysfunction in Severe Chronic Obstructive Pulmonary Disease

2005 • 244 citations

Enhanced neutrophil response in chronic obstructive pulmonary disease

2001 • 237 citations

Injury of the Human Diaphragm Associated with Exertion and Chronic Obstructive Pulmonary Disease

2001 • 235 citations

The role of cytokines in cancer cachexia

1999 • 224 citations

Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation.

2000 • 223 citations

Oxidative Stress in Pathogenesis of Chronic Obstructive Pulmonary Disease: Cellular and Molecular Mechanisms

2005 • 218 citations

Peripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPD

2004 • 218 citations

Cardiac-Specific Overexpression of Tumor Necrosis Factor-α Causes Oxidative Stress and Contractile Dysfunction in Mouse Diaphragm

2000 • 211 citations

Subcellular adaptation of the human diaphragm in chronic obstructive pulmonary disease

1999 • 204 citations

The Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration

2001 • 157 citations

Nitric Oxide Synthases and Protein Oxidation in the Quadriceps Femoris of Patients with Chronic Obstructive Pulmonary Disease

2003 • 153 citations

Role of TNF-α signaling in regeneration of cardiotoxin-injured muscle

2005 • 153 citations

Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation.

1992 • 151 citations

ROS in the local and systemic pathogenesis of COPD

2003 • 145 citations

Human Diaphragm Remodeling Associated with Chronic Obstructive Pulmonary Disease

2003 • 145 citations

Macrophage-released Factor Stimulates Selectively Myogenic Cells in Primary Muscle Culture

1995 • 144 citations

Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis

2002 • 143 citations

Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease

2005 • 142 citations

IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis

1996 • 140 citations

Tumor necrosis factor-α inhibits myogenesis through redox-dependent and -independent pathways

2002 • 132 citations

Insulin-like Growth Factor-II, Phosphatidylinositol 3-Kinase, Nuclear Factor-κB and Inducible Nitric-oxide Synthase Define a Common Myogenic Signaling Pathway

1999 • 126 citations

Side-Stream Cigarette Smoke Induces Dose–Response in Systemic Inflammatory Cytokine Production and Oxidative Stress

2002 • 112 citations

Effect of tumor necrosis factor-α on skeletal muscle metabolism

2001 • 112 citations

Expression of tumor necrosis factor-α in regenerating muscle fibers in inflammatory and non-inflammatory myopathies

2003 • 108 citations

Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones

2005 • 95 citations

Free radical induced respiratory muscle dysfunction.

1998 • 93 citations

Regulation of C2C12 myogenic terminal differentiation by MKK3/p38α pathway

2003 • 90 citations

Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function

1997 • 86 citations

Expression and Carbonylation of Creatine Kinase in the Quadriceps Femoris Muscles of Patients with Chronic Obstructive Pulmonary Disease

2005 • 86 citations

Diaphragm muscle fiber injury after inspiratory resistive breathing.

1997 • 84 citations

Expiratory muscle endurance in chronic obstructive pulmonary disease

2002 • 83 citations

Differential Cytokine Gene Expression in the Diaphragm in Response to Strenuous Resistive Breathing

2004 • 78 citations

Body composition and metabolic rate in rat during a continuous infusion of cachectin

1991 • 70 citations

Altered antioxidant status in peripheral skeletal muscle of patients with COPD

2004 • 67 citations

The Activity of Cytochrome Oxidase Is Increased in Circulating Lymphocytes of Patients with Chronic Obstructive Pulmonary Disease, Asthma, and Chronic Arthritis

2000 • 65 citations

Structural and functional changes in the skeletal muscles of COPD patients: the "compartments" theory.

2001 • 62 citations

Respiratory loading intensity and diaphragm oxidative stress:N-acetyl-cysteine effects

2005 • 53 citations

Regenerating soleus and extensor digitorum longus muscles of the rat show elevated levels of TNF‐α and its receptors, TNFR‐60 and TNFR‐80

2001 • 51 citations

Kinetic analysis of cytokine response to cigarette smoke condensate by human endothelial and monocytic cells

2005 • 45 citations

N-acetylcysteine increases manganese superoxide dismutase activity in septic rat diaphragms

2005 • 41 citations

Proinflammatory Cytokines Regulate Myogenic Cell Proliferation and Fusion but Have No Impact on Myotube Protein Metabolism or Stress Protein Expression

1998 • 37 citations

Parasternal and external intercostal responses to various respiratory maneuvers

1992 • 23 citations

Comparison of 99mTc-DTPA and urea for measuring cefepime concentrations in epithelial lining fluid

2004 • 23 citations

Photoluminescence of δ-doped ZnSe:(Te,N) grown by molecular beam epitaxy

2001 • 10 citations

Morphological and functional recovery from diaphragm injury: an in vivo rat diaphragm injury model

2001 • 9 citations