Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

2001 • 1,113 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

1998 • 820 citations

Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF ^Fbw7 Ubiquitin Ligase

2001 • 733 citations

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

1998 • 678 citations

The F-box protein family.

2000 • 674 citations

Light-Dependent Sequestration of TIMELESS by CRYPTOCHROME

1999 • 553 citations

Cycling vrille Expression Is Required for a Functional Drosophila Clock

1999 • 433 citations

Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP

1999 • 424 citations

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

2001 • 420 citations

Temporal phosphorylation of the Drosophila period protein.

1994 • 410 citations

The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction

1999 • 289 citations

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

2002 • 282 citations

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

2002 • 267 citations

A Role for the Proteasome in the Light Response of the Timeless Clock Protein

1999 • 266 citations

ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCF^βTrCPUbiquitin Ligase

2001 • 243 citations

Phosphorylation of PERIOD Is Influenced by Cycling Physical Associations of DOUBLE-TIME, PERIOD, and TIMELESS in the Drosophila Clock

2001 • 173 citations

Photic Signaling by Cryptochrome in the Drosophila Circadian System

2001 • 163 citations

Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells ofDrosophila cause abnormal behavioral rhythms

2000 • 143 citations

dCLOCK Is Present in Limiting Amounts and Likely Mediates Daily Interactions between the dCLOCK–CYC Transcription Factor and the PER–TIM Complex

2000 • 134 citations

Drosophila CLOCK Protein Is under Posttranscriptional Control and Influences Light-Induced Activity

2002 • 126 citations

RNA Interference of Gene Expression (RNAi) in Cultured Drosophila Cells

2001 • 122 citations

Differential Effects of Light and Heat on the Drosophila Circadian Clock Proteins PER and TIM

1998 • 106 citations

CASEIN KINASE I: ANOTHER COG IN THE CIRCADIAN CLOCKWORKS

2001 • 84 citations

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock

2000 • 82 citations

Role of Posttranscriptional Regulation in Orcadian Clocks: Lessons formDrosophila

1999 • 55 citations

Occurrence of a Putative SCF Ubiquitin Ligase Complex in Drosophila

2001 • 27 citations