Humoral autoimmunity against endothelium: theory or reality?

Toll-like receptors and innate immunity

2001 • 4,138 citations

The Antiphospholipid Syndrome

2002 • 1,551 citations

Apoptotic Vascular Endothelial Cells Become Procoagulant

1997 • 612 citations

Vascular-Bed–Specific Hemostasis and Hypercoagulable States

1999 • 575 citations

Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells.

1994 • 557 citations

Antigenic Heterogeneity of Vascular Endothelium

1991 • 358 citations

Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies

2003 • 315 citations

Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti‐β₂‐Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β₂‐Glycoprotein I and Induce Endothelial Activation

1997 • 293 citations

Presence of complement-fixing anti-endothelial cell antibodies in systemic lupus erythematosus.

1984 • 253 citations

The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis.

1998 • 222 citations

Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95

2000 • 220 citations

IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines.

1996 • 219 citations

Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies

2004 • 218 citations

Dimers of β2-Glycoprotein I Increase Platelet Deposition to Collagen via Interaction with Phospholipids and the Apolipoprotein E Receptor 2′

2003 • 217 citations

Measurement and characterisation of circulating anti-endothelial cell IgG in connective tissue diseases.

1988 • 182 citations

Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis

2001 • 180 citations

Antiphospholipid Syndrome Infectious Origin

2004 • 147 citations

Anti‐endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion

1996 • 141 citations

IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner

1999 • 127 citations

Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: The pathogenic and diagnostic implications

2001 • 125 citations

Anti-platelet factor 4/heparin antibodies from patients with heparin-induced thrombocytopenia provoke direct activation of microvascular endothelial cells

2002 • 116 citations

In vivo analysis of the apoptosis‐inducing effect of anti–endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay

2003 • 112 citations

Characterization of the Endothelial Surface Proteins Recognized by Anti-Endothelial Antibodies in Primary and Secondary Autoimmune Vasculitis

1994 • 107 citations

Endothelial cell activation by antiphospholipid antibodies

2004 • 105 citations

Anti-endothelial cell antibodies in patients withWegener's granulomatosis and micropolyarteritis

1990 • 105 citations

Identification of an autoantibody to vascular endothelial cell-specific antigens in patients with systemic vasculitis

1989 • 101 citations

Anti-endothelial cell IgG fractions from systemic lupus erythematosus patients bind to human endothelial cells and induce a pro-adhesive and a pro-infiammatory phenotype in vitro

1999 • 98 citations

In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.

1999 • 96 citations

Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies

2004 • 95 citations

Pathogenic mechanisms mediating antiphospholipid syndrome

2001 • 95 citations

Induction of endothelial cell apoptosis by heat‐shock protein 60–reactive antibodies from anti–endothelial cell autoantibody–positive systemic lupus erythematosus patients

2004 • 90 citations

Clinical Significance of Anti-endothelial Cell Antibodies in Systemic Vasculitis: A Longitudinal Study Comparing Anti-endothelial Cell Antibodies and Anti-neutrophil Cytoplasm Antibodies

1993 • 84 citations

In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades

2004 • 83 citations

Pathogenic role of anti-endothelial cell antibodies in vasculitis. An idiotypic experimental model.

1996 • 83 citations

Anti-endothelial cell antibodies: detection and characterization using a cellular enzyme-linked immunosorbent assay.

1987 • 82 citations

Atherosclerosis and Autoimmunity

1994 • 82 citations

Different mechanisms by which anti-DNA MoAbs bind to human endothelial cells and glomerular mesangial cells

1992 • 81 citations

Antibodies to endothelial cells in primary vasculitides mediate in vitro endothelial cytotoxicity in the presence of normal peripheral blood mononuclear cells

1992 • 77 citations

Analysis of natural and disease-associated autoantibody repertoires: anti-endothelial cell IgG autoantibody activity in the serum of healthy individuals and patients with systemic lupus erythematosus

1994 • 71 citations

Anti-endothelial cell auto-antibodies in hepatitis C virus mixed cryoglobulinemia

1999 • 67 citations

Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels

1999 • 65 citations

Identification of candidate endothelial cell autoantigens in systemic lupus erythematosus using a molecular cloning strategy: a role for ribosomal P protein P0 as an endothelial cell autoantigen

2000 • 64 citations

Antibody Penetration Into Living Cells: Pathogenic, Preventive and Immuno-Therapeutic Implications

2003 • 63 citations

Antiphospholipid antibodies as cause of pregnancy loss

2004 • 62 citations

Anti-endothelial cell antibody binding makes negatively charged phospholipids accessible to antiphospholipid antibodies

1998 • 60 citations

A need for standardization of the anti-endothelial-cell antibody test

1995 • 59 citations

IgG Binding to Endothelial Cells in Systemic Lupus Erythematosus

1986 • 55 citations

Human monoclonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro

2001 • 54 citations

Disease activity and autoantibodies to endothelial cells in patients with Wegener's granulomatosis

1996 • 53 citations

Endothelial cell binding by human polyclonal anti-DNA antibodies: relationship to disease activity and endothelial functional alterations

1995 • 52 citations

Endothelial cells, antineutrophil cytoplasmic antibodies, and cytokines in the pathogenesis of systemic vasculitis

2004 • 48 citations

Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus.

2003 • 45 citations

Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin‐linked pathway

2002 • 42 citations

Antibodies against astrocyte M₁ and M₂ muscarinic cholinoceptor from schizophrenic patients' sera

2003 • 42 citations

Natural Anti-endothelial Cell Antibodies (AECA)

1999 • 37 citations

Cytotoxic endothelial cell antibodies in mixed connective tissue disease

1989 • 33 citations

Characterization of murine monoclonal anti-endothelial cell antibodies (AECA) produced by idiotypic manipulation with human AECA

1998 • 28 citations

More to death than dying: apoptosis in the pathogenesis of SSA/Ro-SSB/La-associated congenital heart block

2004 • 26 citations

Plasma levels of soluble endothelial cell protein C receptor in patients with Wegener's granulomatosis

2002 • 26 citations

The molecular basis of antiphospholipid syndrome

2003 • 23 citations

The Identification of Endothelial Cell Autoantigens

2000 • 21 citations

Functional and structural characterization of anti-beta1-adrenoceptor autoantibodies of spontaneously hypertensive rats.

2003 • 20 citations

Purification and characterization of an endothelial cell-viability maintaining factor from fetal bovine serum

1995 • 19 citations

[20] Receptor-ligand internalization

1999 • 17 citations

Normal human IgG prevents endothelial cell activation induced by TNFα and oxidized low-density lipoprotein atherogenic stimuli

2003 • 17 citations

Activation of Endothelial Cells by β2-Glycoprotein I (β2GPI) Antibodies Is Mediated by Annexin II Cross Linking and May Involve TLR4.

2004 • 14 citations

Antiphospholipid antibodies: immunological aspects

2004 • 13 citations

An IgM class anti-neutrophil cytoplasm antibody inhibits neutrophil adhesion and apoptosis via a Syk dependent signaling cascade

2004 • 8 citations

Functional Heterogeneity of Pathogenic Anti-Endothelial Cell Antibodies

2001 • 5 citations

Pathogenicity of Antiendothelial Cell Autoantibodies

2001 • 4 citations