Connexins in mammalian heart function

The Gap Junction Communication Channel

1996 • 1,896 citations

Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling

1996 • 1,301 citations

Cardiac Malformation in Neonatal Mice Lacking Connexin43

1995 • 1,242 citations

Cardiac Electrophysiology: From Cell to Bedside

1995 • 1,173 citations

Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells.

1995 • 821 citations

Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of Laterality

1995 • 376 citations

Opposite voltage gating polarities of two closely related onnexins

1994 • 353 citations

Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.

1993 • 324 citations

Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium.

1994 • 294 citations

Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins.

1994 • 286 citations

Intramolecular interactions mediate pH regulation of connexin43 channels

1996 • 263 citations

Selectivity of Connexin-Specific Gap Junctions Does Not Correlate With Channel Conductance

1995 • 258 citations

Functional analysis of selective interactions among rodent connexins.

1995 • 256 citations

Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.

1994 • 254 citations

Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells.

1994 • 240 citations

The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system

1993 • 236 citations

Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs

1992 • 224 citations

Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.

1993 • 218 citations

Restricted distribution of connexin40, a gap junctional protein, in mammalian heart.

1994 • 213 citations

Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells

1995 • 209 citations

Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions.

1993 • 209 citations

Structure of gap junction intercellular channels

1996 • 195 citations

Immunolabelling patterns of gap junction connexins in the developing and mature rat heart

1992 • 188 citations

A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1–1q1

1994 • 183 citations

Expression of Multiple Connexins in Cultured Neonatal Rat Ventricular Myocytes

1995 • 183 citations

Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties

1994 • 180 citations

Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells.

1994 • 177 citations

Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.

1995 • 168 citations

Gap junction channels: distinct voltage-sensitive and -insensitive conductance states

1994 • 167 citations

Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system

1995 • 165 citations

Identification of a proline residue as a transduction element involved in voltage gating of gap junctions

1993 • 160 citations

Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions

1996 • 153 citations

Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells

1995 • 148 citations

TPA Increases Conductance but Decreases Permeability in Neonatal Rat Cardiomyocyte Gap Junction Channels

1995 • 139 citations

Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities

1994 • 138 citations

Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart

1996 • 138 citations

Immunohistochemical delineation of the conduction system. II: The atrioventricular node and Purkinje fibers.

1993 • 126 citations

Differential connexin distribution accommodates cardiac function in different species

1995 • 123 citations

Multiple connexins colocalize in canine ventricular myocyte gap junctions.

1993 • 122 citations

Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle.

1993 • 120 citations

Expression of chimeric connexins reveals new properties of the formation and gating behavior of gap junction channels

1994 • 118 citations

Unique Conductance, Gating, and Selective Permeability Properties of Gap Junction Channels Formed by Connexin40

1995 • 116 citations

Immunohistochemical delineation of the conduction system. I: The sinoatrial node.

1993 • 110 citations

Functional analysis of amino acid sequences in connexin43 involved in intercellular communication through gap junctions

1995 • 109 citations

Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels

1995 • 102 citations

Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43.

1994 • 97 citations

Gap junctional channels in adult mammalian sinus nodal cells. Immunolocalization and electrophysiology.

1992 • 88 citations

Spatial Distribution of Connexin43, the Major Cardiac Gap Junction Protein, Visualizes the Cellular Network for Impulse Propagation From Sinoatrial Node to Atrium

1995 • 74 citations

Modification of gap junction conductance by divalent cations and protons in neonatal rat heart cells

1995 • 73 citations

Functional Analysis of the Connexin43 Gene Promoter in Vivo and in Vitro

1994 • 70 citations

Molecular Cloning of Two Human Cardiac Gap Junction Proteins, Connexin40 and Connexin45

1994 • 65 citations

Voltage dependent gating and single channel analysis of heterotypic gap junction channels formed of Cx45 and Cx43

1995 • 57 citations

pH sensitivity of the cardiac gap junction proteins, connexin 45 and 43

1995 • 49 citations

Expression of Multiple Gap Junction Proteins in Human Fetal and Infant Hearts

1994 • 40 citations

Immunohistochemical Localization of Gap Junction Protein Channels in Hamster Sinoatrial Node in Correlation with Electrophysiologic Mapping of the Pacemaker Region

1994 • 36 citations

Effect of Antipeptide Antibodies Directed against Three Domains of Connexin43 on the Gap Junctional Permeability of Cultured Heart Cells

1996 • 18 citations

Expression and distribution of connexin 40 in mammal heart

1995 • 10 citations

Expression of dog connexin 40 and 45 in paired Xenopus oocytes

1995 • 4 citations

Hiroshima welcomes gap junction communicants

1994 • 4 citations

Mechanism of carbachol-induced decrease of cardiac gap junctional conductance

1995 • 2 citations