Crystal structure of bacterial multidrug efflux transporter AcrB

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Automated MAD and MIR structure solution

1999 • 3,079 citations

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

2000 • 1,768 citations

Maximum-likelihood density modification

2000 • 1,651 citations

Mapping the Protein Universe

1996 • 1,508 citations

Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

2000 • 1,052 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism

2002 • 1,010 citations

AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants

1996 • 798 citations

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

1965 • 715 citations

Structure of MsbA from E. coli : A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters

2001 • 626 citations

The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

1999 • 587 citations

Antibiotic Susceptibility Profiles of Escherichia coli Strains Lacking Multidrug Efflux Pump Genes

2001 • 469 citations

Active efflux of bile salts by Escherichia coli

1997 • 465 citations

Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms.

2001 • 447 citations

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

1999 • 428 citations

Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

1999 • 348 citations

Transmembrane Molecular Pump Activity of Niemann-Pick C1 Protein

2000 • 324 citations

A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria

1994 • 320 citations

Efflux pumps and drug resistance in Gram-negative bacteria

1994 • 284 citations

Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes 1 1Edited by G. von Heijne

2000 • 270 citations

Three-dimensional structure of the ion-coupled transport protein NhaA

2000 • 264 citations

A family of Gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from Gram-negative bacteria

2006 • 249 citations

Multidrug Efflux Pump AcrAB of Salmonella typhimurium Excretes Only Those β-Lactam Antibiotics Containing Lipophilic Side Chains

1998 • 226 citations

AcrA is a highly asymmetric protein capable of spanning the periplasm 1 1Edited by I. B. Holland

1999 • 207 citations

AcrAB and related multidrug efflux pumps of Escherichia coli.

2001 • 205 citations

A family of Gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from Gram-negative bacteria

1997 • 196 citations

Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy

1997 • 179 citations

Reciprocal-space solvent flattening

1999 • 178 citations

Inner membrane efflux components are responsible for beta-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa

1997 • 118 citations

Identification of Essential Charged Residues in Transmembrane Segments of the Multidrug Transporter MexB of Pseudomonas aeruginosa

2001 • 114 citations

Contributions of the AmpC β-Lactamase and the AcrAB Multidrug Efflux System in Intrinsic Resistance of Escherichia coli K-12 to β-Lactams

2000 • 101 citations

Two-Dimensional Crystallization ofEscherichia coliLactose Permease

1999 • 85 citations

Projection structure and molecular architecture of OxlT, a bacterial membrane transporter

2001 • 68 citations

The quarternary molecular architecture of TetA, a secondary tetracycline transporter from Escherichia coli

2000 • 55 citations

Lipid-Layer Crystallization and Preliminary Three-Dimensional Structural Analysis of AcrA, the Periplasmic Component of a Bacterial Multidrug Efflux Pump

2001 • 44 citations

Membrane Topology of a Multidrug Efflux Transporter, AcrB, in Escherichia coli

2002 • 41 citations

How do exported proteins and antibiotics bypass the periplasm in Gram-negative bacterial cells?

2000 • 25 citations