New RNA species is produced by alternate polyadenylation following rearrangement associated withCAD gene amplification

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

GENE AMPLIFICATION

1984 • 580 citations

Identification of procollagen mRNAs transferred to diazobenzyloxymethyl paper from formaldehyde agarose gels

1979 • 564 citations

Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas

1983 • 504 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

α-Thalassaemia caused by a polyadenylation signal mutation

1983 • 407 citations

Are U4 small nuclear ribonucleoproteins involved in polyadenylation?

1984 • 379 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Direct transfer of cloned genes from bacteria to mammalian cells.

1980 • 291 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1976 • 228 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

DNA Rearrangement and Altered RNA Expression of the c-mybOncogene In Mouse Plasmacytoid Lymphosarcomas

1983 • 167 citations

Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis B virus chimeric plasmids.

1983 • 164 citations

Generation of authentic 3′ termini of an H2A mRNA in vivo is dependent on a short inverted DNA repeat and on spacer sequences

1982 • 139 citations

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

1981 • 127 citations

Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.

1984 • 113 citations

The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker

1981 • 104 citations

Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites.

1985 • 102 citations

N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis.

1979 • 95 citations

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: I. Isolation of a mutant defective in the early steps of de novo pyrimidine synthesis

1977 • 78 citations

Structure of Amplified DNA in Different Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

1983 • 75 citations

Structure of the Gene for CAD, the Multifunctional Protein That Initiates UMP Synthesis in Syrian Hamster Cells

1982 • 69 citations

Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.

1983 • 48 citations

Polyadenylic acid addition sites in the adenovirus type 2 major late transcription unit

1983 • 46 citations

The 3′ noncoding region of β-globin mRNA is not essential for in vitro translation

1979 • 43 citations

Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells.

1982 • 42 citations

Similar 150-kilobase DNA sequences are amplified in independently derived methotrexate-resistant Chinese hamster cells.

1985 • 37 citations

Segregation and rearrangement of coamplified genes in different lineages of mutant cells that overproduce adenylate deaminase.

1986 • 37 citations

Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.

1983 • 35 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 34 citations