Successful Culture and Selection of Cytokine Gene-Modified Human Dermal Fibroblasts for the Biologic Therapy of Patients with Cancer

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Experimental and Clinical Studies of Cytokine Gene-Modified Tumor Cells

1994 • 259 citations

Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.

1992 • 187 citations

Treatment of glioma by engineered interleukin 4-secreting cells.

1993 • 149 citations

Construction and Characterization of Retroviral Vectors Expressing Biologically Active Human Interleukin-12

1994 • 131 citations

An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.

1994 • 130 citations

High efficiency gene transfer into primary human tumor explants without cell selection.

1993 • 116 citations

Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines.

1994 • 95 citations

Retroviral vector-mediated lymphokine gene transfer into human renal cancer cells.

1992 • 83 citations

In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocompetence or the state of activation

1994 • 76 citations

Gene Therapy of Cancer: A Pilot Study of IL-4-Gene-Modified Fibroblasts Admixed with Autologous Tumor to Elicit an Immune Response. University of Pittsburgh

1994 • 74 citations

New strategies for active immunotherapy with genetically engineered tumor cells

1992 • 66 citations

Soluble mediators from mononuclear cells increase the synthesis of glycosaminoglycan by dermal fibroblast cultures derived from normal subjects and progressive systemic sclerosis patients

1985 • 58 citations

Transfection of interleukin 2 gene into human melanoma cells augments cellular immune response.

1993 • 41 citations

In Situ Interleukin-4 Gene Expression in Cancer Patients Treated with Genetically Modified Tumor Vaccine

1995 • 31 citations

Local IL-4 delivery enhances immune reactivity to murine tumors: gene therapy in combination with IL-2.

1994 • 22 citations

Human fibroblasts from cancer patients: lifespan and transformed phenotype in vitro and role of mesenchyme in vivo

1988 • 14 citations

IL-2 inhibits the induction of systemic antitumour immunity by IL-4 in the peritumoural treatment of experimental melanoma.

1993 • 5 citations