Cardiovascular and Central Nervous System Effects of Intravenous Levobupivacaine and Bupivacaine in Sheep

Simultaneous Statistical Inference

1981 • 5,665 citations

Toxicological and Local Anaesthetic Effects of Optically Active Isomers of Two Local Anaesthetic Compounds

1972 • 240 citations

Stereoselective Block of Cardiac Sodium Channels by Bupivacaine in Guinea Pig Ventricular Myocytes

1995 • 210 citations

Myocardial Uptake of Bupivacaine

1993 • 161 citations

Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep.

1989 • 142 citations

Hemodynamic and Central Nervous System Effects of Intravenous Bolus Doses of Lidocaine, Bupivacaine, and Ropivacaine in Sheep

1989 • 141 citations

Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea‐pig papillary muscle

1991 • 140 citations

Myocardial and Cerebral Drug Concentrations and the Mechanisms of Death after Fatal Intravenous Doses of Lidocaine, Bupivacaine, and Ropivacaine in the Sheep

1989 • 130 citations

Depression of Myocardial Contractility In Vitro by Bupivacaine, Etidocaine, and Lidocaine

1986 • 121 citations

Comparative Systemic Toxicity of Ropivacaine and Bupivacaine in Nonpregnant and Pregnant Ewes

1995 • 118 citations

Stereoselective Inhibition of Neuronal Sodium Channels by Local Anesthetics Evidence For Two Sites of Action?

1992 • 111 citations

Stereospecific Effect of Bupivacaine Isomers on Atrioventricular Conduction in the Isolated Perfused Guinea Pig Heart

1997 • 101 citations

Enantiomer-specific effects of an intravenously administered arrhythmogenic dose of bupivacaine on neurons of the nucleus tractus solitarius and the cardiovascular system in the anesthetized rat.

1992 • 98 citations

Chronotropic and inotropic effects of ropivacaine, bupivacaine, and lidocaine in the spontaneously beating and electrically paced isolated, perfused rabbit heart.

1992 • 84 citations

Differential Depressant and Electrophysiologic Cardiotoxicity of Local Anesthetics

1986 • 75 citations

Local anesthetics potently block a potential insensitive potassium channel in myelinated nerve.

1995 • 67 citations

DISPOSITION OF MEPIVACAINE AND BUPIVACAINE ENANTIOMERS IN SHEEP †

1991 • 67 citations

Severe Hypoxia Enhances Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Lightly Anesthetized Pigs

1992 • 62 citations

Toxicity and Systemic Effects of Local Anesthetic Agents

1987 • 55 citations

Toxicity of Local Anesthetic Agents

1994 • 55 citations

CARDIOVASCULAR EFFECTS AND REGIONAL CLEARANCES OF I.V. BUPIVACAINE IN SHEEP: ENANTIOMERIC ANALYSIS

1991 • 49 citations

Systemic and Regional Pharmacokinetics of Levobupivacaine and Bupivacaine Enantiomers in Sheep

1998 • 40 citations

Bupivacaine Enantiomer Pharmacokinetics After Intercostal Neural Blockade in Liver Transplantation Patients

1995 • 34 citations

Meeting Highlights: Meeting of the British Pharmacological Society 5 - 7 January 1994, London, UK

1994 • 31 citations

Echocardiographic Evaluation of Bupivacaine Cardiotoxicity

1994 • 28 citations

Functional interaction between local anaesthetics and calcium antagonists in guineapig myocardium: 2. Electrophysiological studies with bupivacaine and nifedipine

1994 • 27 citations

BARBITURATE ANESTHESIA AND ALCOHOLISM IN A RAT MODEL

1986 • 25 citations

Systemic and Regional Pharmacokinetics of Levobupivacaine and Bupivacaine Enantiomers in Sheep

1998 • 25 citations

Pharmacokinetics of bupivacaine enantiomers in sheep: Influence of dosage regimen and study design

1994 • 23 citations

Myocardial Pharmacokinetics of Thiopental in Sheep after Short-Term Administration: Relationship to Thiopental-Induced Reductions in Myocardial Contractility

1996 • 13 citations

The Effects of Bupivacaine and Ropivacaine on Baroreflex Sensitivity With or Without Respiratory Acidosis and Alkalosis in Rats

1997 • 12 citations

Stereochemistry and its relevance in anaesthesiology

1991 • 11 citations

The Effects of Bupivacaine and Ropivacaine on Baroreflex Sensitivity With or Without Respiratory Acidosis and Alkalosis in Rats

1997 • 11 citations

Decreased coronary blood flow is not responsible for myocardial dysfunction during bupivacaine‐induced cardiotoxicity

1996 • 6 citations