Advanced Glycation End-products and Atherosclerosis

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

1992 • 1,488 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.

1994 • 863 citations

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

1992 • 808 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions.

1991 • 669 citations

Lipid advanced glycosylation: pathway for lipid oxidation in vivo.

1993 • 570 citations

Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo

1991 • 534 citations

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.

1991 • 522 citations

Immunochemical detection of advanced glycosylation end products in vivo.

1992 • 496 citations

Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.

1994 • 473 citations

Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.

1994 • 463 citations

Glycation, Glycoxidation, and Cross-Linking of Collagen by Glucose: Kinetics, Mechanisms, and Inhibition of Late Stages of the Maillard Reaction

1994 • 453 citations

Identification of Galectin-3 As a High-Affinity Binding Protein for Advanced Glycation End Products (AGE): A New Member of the AGE-Receptor Complex

1995 • 410 citations

beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis.

1993 • 405 citations

Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat

1991 • 395 citations

Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties.

1989 • 383 citations

Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications.

1992 • 378 citations

Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure

1994 • 374 citations

Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1.

1994 • 335 citations

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.

1985 • 312 citations

Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease.

1994 • 298 citations

Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein

1992 • 291 citations

Post‐Translational Modification of Proteins

1993 • 291 citations

Immunochemical approach to characterize advanced glycation end products of the Maillard reaction

1991 • 266 citations

Hemoglobin-AGE: A Circulating Marker of Advanced Glycosylation

1992 • 255 citations

Advanced Glycation Endproducts Promote Adhesion Molecule (VCAM-1, ICAM-1) Expression and Atheroma Formation in Normal Rabbits

1995 • 241 citations

Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus.

1992 • 215 citations

Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals.

1991 • 210 citations

Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins.

1991 • 189 citations

Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats

1992 • 178 citations

Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors.

1986 • 156 citations

Antibacterial activity of lysozyme and lactoferrin is inhibited by binding of advanced glycation–modified proteins to a conserved motif

1995 • 152 citations

Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats.

1993 • 145 citations

Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats

1992 • 139 citations

Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat

1994 • 126 citations

Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon gamma: role in tissue remodeling.

1993 • 125 citations

Purification and characterization of an Mr 87,000 protein kinase C substrate from rat brain.

1987 • 117 citations

Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats

1992 • 110 citations

The Maillard reaction in vivo

1991 • 108 citations

Prevention of Diabetes-Increased Aging Effect on Rat Collagen-Linked Fluorescence by Aminoguanidine and Rutin

1990 • 105 citations

Chemistry of collagen cross-links: glucose-mediated covalent cross-linking of type-IV collagen in lens capsules

1993 • 101 citations

Crosslines A and B as candidates for the fluorophores in age- and diabetes-related cross-linked proteins, and their diacetates produced by Maillard reaction of α-N-acetyl-<scp>L</scp>-lysine with<scp>D</scp>-glucose

1992 • 98 citations

Advanced glycosylation end-products in experimental murine diabetic nephropathy: effect of islet isografting and of aminoguanidine.

1989 • 94 citations

Prevention of glomerular basement membrane thickening by aminoguanidine in experimental diabetes mellitus

1991 • 91 citations

The 48-kDa subunit of the mammalian oligosaccharyltransferase complex is homologous to the essential yeast protein WBP1.

1992 • 88 citations

Isolation of cDNAs encoding a substrate for protein kinase C: Nucleotide sequence and chromosomal mapping of the gene for a human 80K protein

1989 • 69 citations

Production and characterization of antibodies to advanced glycation products on proteins

1989 • 61 citations

Aminoguanidine treatment reduces the increase in collagen stability of rats with experimental diabetes mellitus

1992 • 60 citations

Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects

1989 • 49 citations

Aminoguanidine reduces regional albumin clearance but not urinary albumin excretion in streptozotocin-diabetic rats

1994 • 30 citations

Aminoguanidine decreases urinary albumin and high-molecular-weight proteins in diabetic rats

1991 • 30 citations

The Effect of Aminoguanidine on the Blood- Retinal Barrier in Streptozocin- Induced Diabetic Rats

1991 • 18 citations