F-actin does not modulate the initial steps of the protein kinase C activation process in living nerve cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Protein kinase C

1991 • 914 citations

Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells

1983 • 736 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

Gap43, Marcks, and Cap23 Modulate Pi(4,5)p2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics through a Common Mechanism

2000 • 591 citations

Latrunculins—novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D

1989 • 566 citations

A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation

1999 • 386 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

Specific Interaction of the PDZ Domain Protein PICK1 with the COOH Terminus of Protein Kinase C-α

1997 • 247 citations

Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity

2000 • 238 citations

Direct Visualization of the Translocation of the γ-Subspecies of Protein Kinase C in Living Cells Using Fusion Proteins with Green Fluorescent Protein

1997 • 228 citations

Modulation of Actin Filament Behavior by GAP-43 (Neuromodulin) Is Dependent on the Phosphorylation Status of Serine 41, the Protein Kinase C Site

1997 • 209 citations

Protein Kinase C and the Cytoskeleton

1998 • 194 citations

Binding of Basic Peptides to Membranes Produces Lateral Domains Enriched in the Acidic Lipids Phosphatidylserine and Phosphatidylinositol 4,5-Bisphosphate: An Electrostatic Model and Experimental Results

1998 • 189 citations

Role of the Cytoskeleton in Calcium Signaling in NIH 3T3 Cells

1997 • 170 citations

RACK1, a Protein Kinase C Anchoring Protein, Coordinates the Binding of Activated Protein Kinase C and Select Pleckstrin Homology Domains in Vitro

1999 • 151 citations

Evidence That Atypical Protein Kinase C-λ and Atypical Protein Kinase C-ζ Participate in Ras-mediated Reorganization of the F-actin Cytoskeleton

1999 • 138 citations

Do neurons have a reserve of sodium channels for the generation of action potentials? A study on acutely isolated CA1 neurons from the guinea‐pig hippocampus

2000 • 137 citations

Three Distinct Mechanisms for Translocation and Activation of the δ Subspecies of Protein Kinase C

1998 • 135 citations

Protein Kinase C βII Specifically Binds to and Is Activated by F-actin

1996 • 133 citations

Molecular Analysis of the Interactions between Protein Kinase C-ε and Filamentous Actin

1998 • 120 citations

Cultured glial cells express the SNAP-25 analogue SNAP-23

1999 • 112 citations

The regulation of neurotransmitter secretion by protein kinase C

1998 • 101 citations

Requirement for Protein Kinase C θ for Cell Cycle Progression and Formation of Actin Stress Fibers and Filopodia in Vascular Endothelial Cells

1997 • 90 citations

Calcium and Protein Kinase C Regulate the Actin Cytoskeleton in the Synaptic Terminal of Retinal Bipolar Cells

1998 • 89 citations

Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction

1999 • 86 citations

Hormone- and phorbol ester-activated protein kinase C isozymes mediate a reorganization of the actin cytoskeleton associated with prolactin secretion in GH4C1 cells.

1992 • 82 citations

Actin disassembles reversibly during electrically induced recycling of synaptic vesicles in cultured neurons

1998 • 78 citations

Effects of rhizopodin and latrunculin B on the morphology and on the actin cytoskeleton of mammalian cells

1999 • 77 citations

Actin filament disruption inhibits L-type Ca²⁺channel current in cultured vascular smooth muscle cells

2000 • 75 citations

Regulation of muscarinic ligand binding sites by nerve growth factor in PC12 phaeochromocytoma cells

1982 • 74 citations

Ca2+ channel Ca2+-dependent inactivation in a mammalian central neuron involves the cytoskeleton

1994 • 74 citations

New fluorescent probes for protein kinase C. Synthesis, characterization, and application

1993 • 69 citations

Physical association and functional relationship between protein kinase Cζ and the actin cytoskeleton

1995 • 59 citations

Simultaneous visualization of the translocation of protein kinase Cα–green fluorescent protein hybrids and intracellular calcium concentrations

1999 • 54 citations

Protein kinase C-δ C2-like domain is a binding site for actin and enables actin redistribution in neutrophils

2001 • 51 citations

Hormone- and phorbol ester-activated protein kinase C isozymes mediate a reorganization of the actin cytoskeleton associated with prolactin secretion in GH4C1 cells

1992 • 38 citations

Protein kinase C-δ C2-like domain is a binding site for actin and enables actin redistribution in neutrophils

2001 • 37 citations

Stimulus-Induced Selective Association of Actin-Associated Proteins (α-Actinin) and Protein Kinase C Isoforms with the Cytoskeleton of Human Neutrophils

1999 • 37 citations

Interaction of Protein Kinase C with Filamentous Actin: Isozyme Specificity Resulting from Divergent Phorbol Ester and Calcium Dependencies

1999 • 34 citations

Differential expression of PKC isoforms and PC12 cell differentiation

1992 • 33 citations

A Single Point Mutation in the V3 Region Affects Protein Kinase Cα Targeting and Accumulation at Cell-Cell Contacts

2001 • 33 citations

Effects of phorbol esters on cytoskeletal proteins in cultured bovine chromaffin cells: induction of neurofilament phosphorylation and reorganization of actin.

1990 • 29 citations

Voltage‐activated lonic currents in differentiating rat cerebellar granule neurons cultured from the external germinal layer

1995 • 21 citations

Regulation of distinct pools of protein kinase C δ in beta cells

1996 • 18 citations

Synergistic Activation of Protein Kinase Cα, -βI, and -γ Isoforms Induced by Diacylglycerol and Phorbol Ester: Roles of Membrane Association and Activating Conformational Changes

1999 • 18 citations

Reversible protein kinase C activation in PC12 cells: effect of NGF treatment

2000 • 17 citations

Effect of PMA on the integrity of the membrane skeleton and morphology of epithelial MDCK cells is dependent on the activity of amiloride-sensitive ion transporters and membrane potential.

1997 • 17 citations

Effects of Mushroom Toxins on Glycogenolysis; Comparison of Toxicity of Phalloidin, .ALPHA.-Amanitin and DL-Propargylglycine in Isolated Rat Hepatocytes.

1992 • 11 citations

Rapid in Vitro Conformational Changes of the Catalytic Site of PKCα Assessed by FIM-1 Fluorescence

1999 • 10 citations

Molecular genetics and heterogeneity in manic depression

1988 • 7 citations