Validation of an in vitro screen for phospholipidosis using a high-content biology platform

Cationic Amphiphilic Drug-Induced Phospholipidosis

1997 • 343 citations

Drug-Induced Phospholipidosis: Are There Functional Consequences?

2001 • 259 citations

A Toxicogenomic Approach to Drug-Induced Phospholipidosis: Analysis of Its Induction Mechanism and Establishment of a Novel in Vitro Screening System

2004 • 219 citations

Cationic amphiphilic drugs and phospholipid storage disorder.

1990 • 193 citations

Hepatic side-effects of antibiotics

1994 • 173 citations

Electron microscopic demonstration of lysosomal inclusion bodies in lung, liver, lymph nodes, and blood leukocytes of patients with amiodarone pulmonary toxicity

1985 • 121 citations

A review of the biology and toxicologic implications of the induction of lysosomal lamellar bodies by drugs

1989 • 115 citations

Studies on drug-induced lipidosis: subcellular localization of phospholipid and cholesterol in the liver of rats treated with chloroquine or 4,4'-bis (diethylaminoethoxy)alpha, beta-diethyldiphenylethane.

1980 • 107 citations

Chloroquine-induced phospholipid fatty liver. Measurement of drug and lipid concentrations in rat liver lysosomes.

1985 • 84 citations

Accumulation of weak bases in relation to intralysosomal pH in cultured human skin fibroblasts

1981 • 79 citations

A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development.

2003 • 77 citations

Amiodarone ? an inhibitor of phospholipase activity: a comparative study of the inhibitory effects of amiodarone, chloroquine and chlorpromazine

1987 • 73 citations

Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs.

1976 • 70 citations

Types of interaction of amphiphilic drugs with phospholipid vesicles.

1988 • 65 citations

In vitro inhibition of lysosomal phospholipase A1 of rat lung by amiodarone and desethylamiodarone

1988 • 65 citations

Evidence for lysosomotropic action of desipramine in cultured human fibroblasts.

1983 • 60 citations

Fluoxetine Hydrochloride (Prozac)-Induced Pulmonary Disease

1995 • 60 citations

Fluorescence studies on binding of amphiphilic drugs to isolated lamellar bodies: relevance to phospholipidosis

1989 • 59 citations

Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity

1996 • 57 citations

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes11Abbreviations: MMP, matrix metalloproteinase; MMPI, matrix metalloproteinase inhibitor; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; NBD-PE, N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; and MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; DMSO, dimethylsulfoxide; HPLC, high …

2001 • 55 citations

Studies on the mechanism of phospholipid storage induced by amantadine and chloroquine in Madin Darby canine kidney cells

1982 • 52 citations

Tamoxifen-induced generalized lipidosis in rats subchronically treated with high doses

1981 • 51 citations

Cationic amphiphilic drug-induced renal cortical lysosomal phospholipidosis: An in vivo comparative study with gentamicin and chlorphentermine

1987 • 37 citations

Citalopram‐induced Generalized Lipidosis in Rats

1983 • 35 citations

An in Vitro Fluorescence Assay for the Detection of Drug-Induced Cytoplasmic Lamellar Bodies

1991 • 35 citations

Amiodarone toxicity *1II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats

1991 • 33 citations

Ketoconazole-induced hepatic phospholipidosis in the mouse and its association with de-N-acetyl ketoconazole

1994 • 30 citations

Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus

1979 • 22 citations

In Vivo and In Vitro Reversibility of Chlorphentermine-Induced Phospholipidosis in Rat Alveolar Macrophages

1995 • 22 citations

Morphological changes in CNS of rats treated with perhexiline maleate (Pexid)

1978 • 20 citations

In vivo toxicity and pulmonary effects of promazine and chlorpromazine in rats

1990 • 20 citations

Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver

1983 • 19 citations

Reversible, hepatic, lysosomal phospholipidosis in rat induced by subchronic daily administration of trospectomycin sulfate

1989 • 16 citations

Species and dose differences in the accumulation of imipramine by mammalian lungs.

1981 • 16 citations

Zimelidine‐Induced Lipidosis in Rats

1980 • 16 citations

In Vitroandin VivoUltrastructural Changes Induced by Macrolide Antibiotic LY281389

1996 • 13 citations

Cytotoxicity and lamellar body induction potential of a racemic benzamide antiarrhythmic compound and enantiomers in cultured rat hepatocytes

1994 • 12 citations

MORPHOLOGICAL AND BIOCHEMICAL ALTERATION IN THE RAT LIVER INDUCED BY MAPROTILINE

1975 • 11 citations

Mrphological and Functional Changes in Mouse Splenic Lymphocytes Following<u>in Vivo</u>and in<u>Vitro</u>Exposure to Chlorphentermine

1986 • 9 citations

Newborn response to cationic amphiphilic drugs.

1985 • 4 citations