Fluorescence studies on binding of amphiphilic drugs to isolated lamellar bodies: relevance to phospholipidosis

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

[6]Isolation of rat liver plasma membrane fragments in isotonic sucrose

1974 • 609 citations

Lipidosis induced by amphiphilic cationic drugs

1978 • 353 citations

ISOLATION AND CHARACTERIZATION OF LAMELLAR BODIES AND TUBULAR MYELIN FROM RAT LUNG HOMOGENATES

1973 • 260 citations

A Colorimetric Method for the Estimation of Succinic Dehydrogenase Activity

1960 • 249 citations

Inorganic phosphate assay with malachite green: An improvement and evaluation

1982 • 243 citations

Partition of chlorpromazine into lipid bilayer membranes: the effect of membrane structure and composition

1986 • 166 citations

Sarcoplasmic reticulum

1969 • 164 citations

Amiodarone lung: Pathologic finding in clinically toxic patients

1987 • 146 citations

Destruction of liver microsomal calcium pump activity by carbon tetrachloride and bromotrichloromethane

1981 • 123 citations

The binding of drugs to different polar lipids in vitro

1979 • 121 citations

Pulmonary and generalized lysosomal storage induced by amphiphilic drugs.

1984 • 112 citations

Studies on the mechanism of drug-induced lipidosis

1981 • 110 citations

Lung Concentric Laminar Organelle

1974 • 109 citations

NMR-Studies on the molecular basis of drug-induced phospholipidosis—II. Interaction between several amphiphilic drugs and phospholipids

1976 • 106 citations

Amiodarone-Associated Pulmonary Toxicity: A Clinical and Pathologic Study of Eleven Cases

1987 • 105 citations

Graphical analysis of ligand-binding systems: Evaluation by Monte Carlo studies

1980 • 104 citations

A convenient and sensitive fluorescence assay for phospholipid vesicles using diphenylhexatriene

1978 • 102 citations

The Localization, Metabolism, and Effects of Drugs and Toxicants in Lung

1975 • 85 citations

Mechanism of cationic amphiphilic drug inhibition of purified lysosomal phospholipase A1

1985 • 83 citations

Drug-induced lipidosis and the alveolar macrophage

1981 • 78 citations

Hydrolases of pulmonary lysosomes and lamellar bodies.

1982 • 77 citations

Bronchoalveolar Lavage in Amiodarone Pneumonitis

1987 • 74 citations

The isolation of lamellar bodies and their membranous content from rat lung, lamb tracheal fluid and human amniotic fluid

1978 • 71 citations

Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs.

1976 • 70 citations

Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects.

1988 • 66 citations

Types of interaction of amphiphilic drugs with phospholipid vesicles.

1988 • 65 citations

Electrostatic interactions in the binding of fluorescent probes to lipid membranes

1973 • 57 citations

Active uptake of propranolol by isolated rabbit alveolar macrophages and its inhibition by other basic amines.

1980 • 46 citations

Influence of various cationic amphiphilic drugs on the phase-transition temperature of phosphatidylcholine liposomes

1983 • 45 citations

Pulmonary sequestration of amiodarone and desethylamiodarone.

1986 • 45 citations

Fluorescence Spectroscopy of Biological Membranes

1981 • 42 citations

Fluorescence studies of the binding of amphiphilic amines with phospholipids.

1985 • 41 citations

PHYSIOLOGICAL DISTRIBUTION AND METABOLIC INACTIVATION OF CHLORCYCLIZINE AND CYCLIZINE.

1965 • 41 citations

Recovery from amiodarone-induced lipidosis in laboratory animals: A toxicological study

1984 • 39 citations

Influence of cationic amphiphilic drugs on the phosphatidylcholine hydrolysis by phospholipase A2

1987 • 34 citations

Metabolism of chlorpromazine by pulmonary microsomal enzymes in the rat and rabbit

1982 • 31 citations

Drug-Induced Foam Cell Reactions in Rats, II. Chemical Analysis of Lipids Stored in Lungs and Foam Cells after Treatment with Chlorphentermine, 5-[p-(Fluoren-9-ylidenemethyl)phenyl]-2-piperidineethanol (RMI 10.393) and 1-Chloramitriptyline

1975 • 31 citations

Distribution and metabolism of chlorphentermine-C14 in rats and mice

1968 • 30 citations

Species Differences in Pulmonary N-Oxidation of Chlorpromazine and Imipramine

1984 • 24 citations

Alterations in rat alveolar surfactant phospholipids and proteins induced by administration of chlorphentermine

1986 • 23 citations

Stereoselective oxidative metabolism of propranolol in the microsomal fraction from rat and human liver. Use of deuterium labeling and pseudoracemic mixtures.

1986 • 22 citations

Effect of amiodarone on Na⁺‐, K⁺‐ATPase and Mg²⁺‐ATPase activities in rat brain synaptosomes

1986 • 21 citations

N-oxidation of imipramine by isolated perfused rat and rabbit lung

1980 • 20 citations

Effect of cytochrome P-450 and flavin-containing monooxygenase modifying factors on the in vitro metabolism of amiodarone by rat and rabbit.

1987 • 18 citations

Chlorphentermine uptake by isolated perfused rabbit lung

1980 • 18 citations

Structure and function of propranolol: A β‐adrenergic blocking drug

1981 • 17 citations

Pulmonary Metabolism of Imipramine in the Rat and Rabbit

1981 • 16 citations

Uptake and metabolism of chlorpromazine by rat and rabbit lungs.

1980 • 16 citations

Role of drug metabolism in protection against chlorphentermine-induced pulmonary phospholipidosis in adult rat

1981 • 12 citations

Changes of transition temperatures of phosphatidylcholine and phosphatidylglycerol in presence of amphiphilic drugs

1986 • 9 citations

Reductive dechlorination of chloramphenicol by rat liver microsomes.

1983 • 4 citations

Drug-Specificity in the Perturbation of Pulmonary Disposition of Serotonin in Rabbit in vivo

1983 • 2 citations