Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

1992 • 979 citations

Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells

1997 • 592 citations

Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells

2001 • 586 citations

Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles

1998 • 509 citations

Radiation-Induced Bystander Effects: Past History and Future Directions

2001 • 496 citations

Induction of a bystander mutagenic effect of alpha particles in mammalian cells

2000 • 473 citations

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

1997 • 445 citations

Studies of bystander effects in human fibroblasts using a charged particle microbeam

1998 • 410 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures.

2002 • 325 citations

The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated Cells

2001 • 308 citations

Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target

1996 • 286 citations

Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-Particle Radiation: Evidence for a Bystander Effect

1999 • 265 citations

Radiation risk to low fluences of α particles may be greater than we thought

2001 • 218 citations

Isoleucine-mediated regulation of genome repliction in various mammalian cell lines.

1971 • 188 citations

Free Radical-Initiated and Gap Junction-Mediated Bystander Effect due to Nonuniform Distribution of Incorporated Radioactivity in a Three-Dimensional Tissue Culture Model

2001 • 153 citations

HPRTMutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations

2001 • 133 citations

Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles

2002 • 106 citations

The Chinese hamster HPRT gene: Restriction map, sequence analysis, and multiplex PCR deletion screen

1991 • 89 citations

Design of a Benchtop Alpha Particle Irradiator

1995 • 57 citations

The application of the microbial “tooth-pick” technique to somatic cell genetics, and its use in the isolation of X-ray sensitive mutants of chinese hamster ovary cells

1982 • 52 citations

A Possible Role of Ku in Mediating Sequential Repair of Closely Opposed Lesions

2001 • 30 citations

A mutation in codon 717 of the CHO-K1 elongation factor 2 gene prevents the first step in the biosynthesis of diphthamide

1992 • 20 citations

Molecular structural analysis of 417 HPRT mutations induced by restriction endonucleases in Chinese hamster ovary (CHO) cells

1995 • 18 citations

The molecular nature of spontaneous mutations at the hprt locus in the radiosensitive CHO mutant xrs-5

1996 • 5 citations