Functional analogues of bleomycin: DNA cleavage by bleomycin and hemin-intercalators

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses

1984 • 477 citations

Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.

1981 • 458 citations

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

1981 • 415 citations

Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

1982 • 403 citations

Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II).

1982 • 332 citations

gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.

1983 • 319 citations

Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

1978 • 299 citations

3'-Phosphatase activity in T4 polynucleotide kinase

1977 • 272 citations

Interaction of bleomycin with DNA.

1978 • 250 citations

Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II).

1985 • 243 citations

Origin of malondialdehyde from DNA degraded by Fe(II) x bleomycin.

1980 • 172 citations

DNA affinity cleaving

1984 • 153 citations

Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysate.

1978 • 139 citations

Design synthesis of a sequence-specific DNA cleaving molecule. (Distamycin-EDTA)iron(II)

1982 • 124 citations

Calculation of Van der Waals Interactions and Hydrogen Bonding in Crystals

1969 • 99 citations

Synthetic analogues and biosynthetic intermediates of bleomycin. Metal-binding, dioxygen interaction, and implication for the role of functional groups in bleomycin action mechanism.

1983 • 72 citations

Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage.

1982 • 67 citations

Altered mobility of polydeoxyribonucleotides in high resolution polyaciylamide gels due to removal of terminal phosphates

1981 • 64 citations

Modification of DNA with potent mutacarcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole isolated from a glutamic acid pyrolysate: structure of the modified nucleic acid base and initial chemical event caused by the mutagen

1982 • 61 citations

Sequence-specific double-strand cleavage of DNA by bis(EDTA-distamycin.iron(II)) and EDTA-bis(distamycin).iron(II)

1983 • 56 citations

Interactions of bleomycin with DNA

1980 • 37 citations

Mutagenic chemistry of heteroaromatic amines and mitomycin C

1984 • 32 citations

The bleomycins: Antitumor copper-binding antibiotics

2005 • 31 citations

Bleomycin models. Haemin–acridines which bind to DNA and cause oxygen-dependent scission

1982 • 29 citations

Synthesis of porphyrin(Fe)-intercalators which cause DNA scission

1983 • 26 citations

Non-covalent interaction with DNA of the mutagens 2-amino-dipyrido[1,2-a:3′,2′-d]imidazole and methyl-substituted isomers

1980 • 19 citations

Interaction of mutagens isolated from L-glutamic acid pyrolysate with DNA

1980 • 13 citations