The high affinity receptor for IgE on mast cells

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

1990 • 975 citations

Complete structure and expression in transfected cells of high affinity IgE receptor

1989 • 515 citations

Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

1989 • 494 citations

Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.

1977 • 366 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

1984 • 351 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

Hydrophobic Organization of Membrane Proteins

1989 • 316 citations

THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS

1974 • 307 citations

Localization of the binding site for the human high-affinity Fc receptor on IgG

1988 • 287 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

A macrophage Fcγ receptor and the mast cell receptor for IgE share an identical subunit

1989 • 268 citations

Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.

1990 • 234 citations

Complete structure of the mouse mast cell receptor for IgE (Fc ϵ RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells

1989 • 231 citations

The mast cell binding site on human immunoglobulin E

1988 • 221 citations

Expression of High-affinity Binding of Human Immunoglobulin E by Transfected Cells

1989 • 194 citations

A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of FcγRIII

1989 • 189 citations

Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells

1985 • 186 citations

Effect of Antigen Binding on the Properties of Antibody

1974 • 182 citations

IgE-mediated degranulation of mast cells does not require opening of ion channels

1986 • 179 citations

Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell

1978 • 167 citations

Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.

1990 • 163 citations

Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells.

1980 • 151 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Lateral motion and valence of Fc receptors on rat peritoneal mast cells

1976 • 144 citations

Structural Mutations of the T Cell Receptor ζ Chain and Its Role in T Cell Activation

1990 • 132 citations

Rat mast cells permeabilised with streptolysin O secrete histamine in response to Ca2+ at concentrations buffered in the micromolar range

1987 • 126 citations

Antibody-cell interactions: Fc receptors

1989 • 126 citations

SURFACE IgE ON HUMAN BASOPHILS DURING HISTAMINE RELEASE

1973 • 113 citations

Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.

1988 • 113 citations

Cross-linking of receptor-bound IgE to aggregates larger than dimers leads to rapid immobilization.

1986 • 112 citations

A cDNA presumptively coding for the .alpha. subunit of the receptor with high affinity for immunoglobulin E

1987 • 111 citations

Fc receptors and the action of antibodies

1991 • 110 citations

Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E.

1988 • 109 citations

Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells.

1985 • 104 citations

Signal Transduction and Cellular Response in RBL-2H3 Mast Cells

2015 • 103 citations

Triggering of Cultured Neoplastic Mast Cells by Antibodies to the Receptor for IgE

1978 • 101 citations

The high-affinity receptor for IgE

1990 • 101 citations

Studies with a monoclonal antibody to the β subunit of the receptor with high affinity for immunoglobulin E

1988 • 96 citations

Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor

1988 • 92 citations

The cromolyn binding protein constitutes the Ca2+ channel of basophils opening upon immunological stimulus.

1984 • 92 citations

Morphologic and immunologic characterization of human basophils developed in cultures of cord blood mononuclear cells.

1985 • 91 citations

Membrane Phosphoinositide-Activated Signals in Mast Cells and Basophils1

2015 • 91 citations

Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release.

1987 • 90 citations

Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19.

1988 • 85 citations

Cross-linking of immunoglobulin E-receptor complexes induces their interaction with the cytoskeleton of rat basophilic leukemia cells.

1986 • 75 citations

Distribution and valency of receptor for IgE on rodent mast cells and related tumour cells

1976 • 74 citations

Composition and subunit structure of the cell receptor for immunoglobulin E.

1980 • 70 citations

Translocation of protein kinase C in rat basophilic leukemic cells induced by phorbol ester or by aggregation of IgE receptors.

1988 • 69 citations

Rat mast cells permeabilized with Sendai virus secrete histamine in response to Ca2+ buffered in the micromolar range

1983 • 68 citations

Histamine Release from Rat Mast Cells by Antibodies against Rat Basophilic Leukemia Cell Membrane

1977 • 67 citations

Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19.

1989 • 63 citations

Early expression of high-affinity receptor for immunoglobulin E (Fc epsilon RI) during differentiation of mouse mast cells and human basophils.

1990 • 61 citations

Small oligomers of immunoglobulin E (IgE) cause large-scale clustering of IgE receptors on the surface of rat basophilic leukemia cells.

1984 • 58 citations

Surface expression of mutated subunits of the high affinity mast cell receptor for IgE.

1990 • 52 citations

Antigen‐Dependent transition of IgE to a detergent‐insoluble form is associated with reduced IgE receptor‐dependent secretion from RBL‐2H3 mast cells

1990 • 51 citations

Cross-linking of IgE-receptor complexes by rigid bivalent antigens greater than 200 A in length triggers cellular degranulation.

1988 • 51 citations

Dissociation of the receptor for immunoglobulin E in mild detergents

1985 • 50 citations

Phosphatidylcholine is a quantitatively more important source of increased 1,2-diacylglycerol than is phosphatidylinositol in mast cells.

1990 • 44 citations

Receptor-mediated release of inositol 1,4,5-trisphosphate and inositol 1,4-bisphosphate in rat basophilic leukemia RBL-2H3 cells permeabilized with streptolysin O

1989 • 42 citations

Immobilization and internalization of mutated IgE receptors in transfected cells.

1991 • 41 citations

The cell surface receptor for immunoglobulin E. Effect of tunicamycin on molecular properties of receptor from rat basophilic leukemia cells.

1981 • 40 citations

The receptor for immunoglobulin E: Examination for kinase activity and as a substrate for kinases

1986 • 39 citations

Aggregation of IgE receptors induces degranulation in rat basophilic leukemia cells permeabilized with alpha-toxin from Staphylococcus aureus.

1988 • 35 citations

Expression and characterization of a truncated murine Fc gamma receptor.

1988 • 34 citations

Changes in the receptor for immunoglobulin E coincident with receptor-mediated stimulation of basophilic leukemia cells

1983 • 29 citations

Subthreshold and Suboptimal Desensitization of Human Basophils

1982 • 29 citations

Selective phosphorylation of the IgE receptor in antigen-stimulated rat mast cells.

1983 • 28 citations

Transmembrane signaling in P815 mastocytoma cells by transfected IgE receptors.

1990 • 28 citations

Interaction of IgE with Its High-Affinity Receptor

1989 • 27 citations

Internalization of ige receptors on rat basophilic leukemic cells by phorbol ester. comparison with endocytosis induced by receptor aggregation

1989 • 26 citations

Calcium specificity of the antigen-induced channels in rat basophilic leukemia cells

1988 • 25 citations

IgE receptor-mediated hydrolysis of phosphoinositides by cytoplasts from rat basophilic leukemia cells.

1989 • 21 citations

Isolation and purification of an Fc.epsilon. receptor activated ion channel from the rat mast cell line RBL-2H3

1988 • 19 citations

Covalent crosslinking of subunits of the receptor for immunoglobulin E induced by immunoprecipitation

1983 • 18 citations

Calcium: An Important Second Messenger in Mast Cells

2007 • 14 citations

Fc epsilon RI-mediated hydrolysis of phosphoinositides in ghosts derived from rat basophilic leukemia cells.

1991 • 12 citations

Is There Specificity Involved in Fcε Receptor Aggregation Which Leads to an Effective Secretory Stimulus?

1989 • 8 citations

Rapid phosphorylation of a 92,000 MW protein on activation of rat basophilic leukaemia cells for histamine release.

1987 • 6 citations

The High Affinity Receptor for Immunoglobulin E: New Developments

1989 • 4 citations