Clinical implications of the stress response.

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Protein folding in the cell

1992 • 4,138 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

MOLECULAR CHAPERONES

1991 • 1,089 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Heat shock protein 70-associated peptides elicit specific cancer immunity.

1993 • 631 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

1993 • 494 citations

How Cells Respond to Stress

1993 • 481 citations

Stress proteins, infection, and immune surveillance

1989 • 477 citations

A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein.

1991 • 445 citations

Hyperthermia Protects Against Light Damage in the Rat Retina

1988 • 445 citations

Induction of Salmonella Stress Proteins Upon Infection of Macrophages

1990 • 429 citations

Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity.

1992 • 412 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

Chlamydial disease pathogenesis. The 57-kD chlamydial hypersensitivity antigen is a stress response protein.

1989 • 334 citations

Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion?

1992 • 323 citations

Protein Folding in the Cell: The Role of Molecular Chaperones Hsp70 and Hsp60

1992 • 306 citations

Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin

1994 • 297 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

Activation of Heat Shock Factor 2 during Hemin-Induced Differentiation of Human Erythroleukemia Cells

1992 • 281 citations

Heat-shock response and limitation of tissue necrosis during occlusion/reperfusion in rabbit hearts.

1993 • 278 citations

Recognition of heat shock proteins and γΔ cell function

1990 • 247 citations

Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins

1992 • 232 citations

Steroid receptors and their associated proteins

1993 • 231 citations

Interaction of the Rous Sarcoma Virus Protein pp60 src with the Cellular Proteins pp50 and pp90

1986 • 223 citations

Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes.

1990 • 221 citations

Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response.

1991 • 215 citations

Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response.

1993 • 214 citations

Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis

1991 • 199 citations

Flavonoids inhibit the expression of heat shock proteins.

1990 • 183 citations

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

1989 • 179 citations

Autoimmunity to Chaperonins in the Pathogenesis of Arthritis and Diabetes

1991 • 172 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.

1992 • 168 citations

Induction of Heat Stress Proteins Is Associated with Decreased Mortality in an Animal Model of Acute Lung Injury

1993 • 160 citations

A 66-kilodalton heat shock protein of Salmonella typhimurium is responsible for binding of the bacterium to intestinal mucus

1992 • 160 citations

Heat shock protein expression in vulnerable cells of the rat hippocampus as an indicator of excitation-induced neuronal stress

1992 • 158 citations

Mycobacterial heat‐shock proteins as carrier molecules

1991 • 122 citations

Heat-shock proteins: Immunity and autoimmunity

1992 • 122 citations

Synthesis of stress proteins in rat cardiac myocytes 2-4 days after imposition of hemodynamic overload.

1988 • 116 citations

Mycobacterial heat‐shock proteins as carrier molecules. II: The use of the 70‐kDa mycobacterial heat‐shock protein as carrier for conjugated vaccinescan circumvent the need for adjuvants and Bacillus Calmette Guérin priming)

1992 • 114 citations

A malaria heat‐shock‐like determinant expressed on the infected hepatocyte surface is the target of antibody‐dependent cell‐mediated cytotoxic mechanisms by nonparenchymal liver cells

1990 • 110 citations

Heat shock proteins in immune responses.

1993 • 88 citations

Protective immunization of the squirrel monkey against asexual blood stages of Plasmodium falciparum by use of parasite protein fractions.

1984 • 84 citations

An 80-kilodalton antigen from Histoplasma capsulatum that has homology to heat shock protein 70 induces cell-mediated immune responses and protection in mice

1992 • 84 citations

Molecular response to surgical stress: specific and simultaneous heat shock protein induction in the adrenal cortex, aorta, and vena cava.

1991 • 83 citations

Major cytoplasmic membrane protein of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, induces protective immunity in a guinea pig model of Legionnaires' disease.

1993 • 81 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1994 • 75 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 75 citations

T cell and antibody reactivity with the Borrelia burgdorferi 60-kDa heat shock protein in Lyme arthritis.

1991 • 57 citations

Improving Acute Skin-Flap Survival Through Stress Conditioning Using Heat Shock and Recovery

1992 • 49 citations

Dopaminergic regulation of heat shock protein-70 expression in adrenal gland and aorta.

1993 • 44 citations

Whole body heat stress fails to limit infarct size in the reperfused rabbit heart

1992 • 42 citations

Antigenic analysis of the chlamydial 75-kilodalton protein

1992 • 27 citations

Dopaminergic regulation of heat shock protein-70 expression in adrenal gland and aorta

1993 • 20 citations

Autoimmunity To Chaperonins In The Pathogenesis Of Arthritis And Diabetes

1991 • 9 citations

Mucosal immunology

1990 • 8 citations

Heat-shock proteins: immunity and autoimmunity

1992 • 7 citations

Heat shock proteins and autoimmunity: facts or fiction?

1991 • 6 citations

4 Thermotolerance, Thermoresistance, and Thermosensitization

1990 • 6 citations