The Signal Sequence of Lymphocytic Choriomeningitis Virus Contains an Immunodominant Cytotoxic T Cell Epitope That Is Restricted by both H-2Dband H-2KbMolecules

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.

1991 • 334 citations

Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex.

1980 • 306 citations

Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

1992 • 295 citations

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides

1993 • 256 citations

Peptide selection by MHC class I molecules

1991 • 253 citations

The three-dimensional structure of H-2Db at 2.4 Å resolution: Implications for antigen-determinant selection

1994 • 243 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

1993 • 224 citations

Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype.

1995 • 213 citations

Several HLA alleles share overlapping peptide specificities.

1995 • 197 citations

Localization of allodeterminants on H-2Kb antigens determined with monoclonal antibodies and H-2 mutant mice.

1982 • 194 citations

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.

1996 • 189 citations

Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.

1988 • 166 citations

Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus

1988 • 155 citations

Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor

1988 • 151 citations

An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

1995 • 145 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a K^b‐restricted ovalbumin peptide and an assessment of the predictive power of MHC‐binding motifs

1992 • 134 citations

Vaccination and protection from a lethal viral infection: Identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope

1990 • 132 citations

Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.

1994 • 126 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations.

1994 • 112 citations

Similar antigenic surfaces, rather than sequence homology, dictate T-cell epitope molecular mimicry.

1995 • 99 citations

Broad recognition of cytotoxic T cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules.

1992 • 97 citations

The MHC class l-restricted T cell response to Sendai virus infection in C57BL/6 mice: a single immunodominant epitope elicits an extremely diverse repertoire of T cells

1994 • 95 citations

Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus

1995 • 91 citations

Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule

1995 • 89 citations

Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen

1995 • 87 citations

Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus.

1992 • 86 citations

CTL Escape Viral Variants

1995 • 83 citations

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

1994 • 82 citations

Expression of adenoviral E3 transgenes in β cells prevents autoimmune diabetes

1997 • 81 citations

Different MHC class I alleles compete for presentation of overlapping viral epitopes

1995 • 75 citations

Quantitation of peptide anchor residue contributions to class I major histocompatibility complex molecule binding.

1993 • 70 citations

Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition

1997 • 66 citations

Differences in peptide presentation between B27 subtypes: The importance of the P1 side chain in maintaining high affinity peptide binding to B★2703

1994 • 65 citations

Binding of Viral Antigens to Major Histocompatibility Complex Class I H-2Db Molecules Is Controlled by Dominant Negative Elements at Peptide Non-anchor Residues

1996 • 62 citations

CTL Escape Viral Variants

1995 • 59 citations

Viral mutations, TCR antagonism and escape from the immune response

1995 • 58 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants.

1984 • 57 citations

A common antiviral cytotoxic T-lymphocyte epitope for diverse major histocompatibility complex haplotypes: implications for vaccination.

1992 • 55 citations

Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation.

1994 • 48 citations

Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection

1995 • 48 citations

Multiple pathways are involved in the extracellular processing of MHC class I-restricted peptides.

1993 • 48 citations

Preferred size of peptides that bind to H‐2 K^b is sequence dependent

1992 • 44 citations

The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes.

1995 • 41 citations

Binding of nonamer peptides to three HLA-B51 molecules which differ by a single amino acid substitution in the A-pocket

1996 • 37 citations

The peptide binding specificity of HLA-B27 subtypes

1994 • 37 citations

The essence of epitopes.

1994 • 36 citations

HLA Photoaffinity Labeling Reveals Overlapping Binding of Homologous Melanoma-associated Gene Peptides by HLA-A1, HLA-A29, and HLA-B44

1996 • 24 citations

Role for MHC class I molecules in selecting and protecting high affinity peptides in the presence of proteases.

1994 • 20 citations

Relative implication of peptide residues in binding to major histocompatibility complex class I H-2Db: application to the design of high-affinity, allele-specific peptides

1995 • 20 citations

Cytotoxic T cell repertoire selection. A single amino acid determines alternative class I restriction.

1994 • 19 citations

The peptide-binding specificity of HLA-B27 subtype (B∗2705) analyzed by the use of polyalanine model peptides

1994 • 14 citations

Presentation of a horse cytochrome c peptide by multiple H‐2^b class I major histocompatibility complex (MHC) molecules to C57BL/6‐ and bm1‐derived cytotoxic T lymphocytes: Presence of a single MHC anchor residue may confer efficient peptide‐specific CTL recognition

1994 • 6 citations