The influence of nickel and cobalt on putative members of the oxygen‐sensing pathway of erythropoietin‐producing HepG2 cells

Fenton's reagent revisited

1975 • 2,778 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

An essential role for free radicals and derived species in signal transduction

1997 • 909 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Oxygen(es) and the hypoxia-inducible factor-1.

1997 • 518 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

DNA Binding and Dimerization of the Fe−S-containing FNR Protein from Escherichia coli Are Regulated by Oxygen

1996 • 310 citations

Biological origin of free radicals, and mechanisms of antioxidant protection

1994 • 308 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Neutrophil signal transduction and activation of the respiratory burst

1993 • 262 citations

A versatile time-sharing multichannel spectrophotometer, reflectometer, and fluorometer

1975 • 238 citations

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1994 • 233 citations

In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction

1993 • 198 citations

Generation of Putative Intrastrand Cross-Links and Strand Breaks in DNA by Transition Metal Ion-Mediated Oxygen Radical Attack

1997 • 170 citations

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

1996 • 151 citations

Nickel induced lipid peroxidation in the rat: correlation with nickel effect on antioxidant defense systems

1990 • 134 citations

Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells.

1996 • 131 citations

Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2)

1993 • 93 citations

Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells

1997 • 84 citations

A comparison of cobalt(II) and iron(II) hydroxyl and superoxide free radical formation

1989 • 81 citations

Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species

1997 • 79 citations

X‐ray microanalysis of freeze‐dried and frozen‐hydrated cryosections

1988 • 70 citations

New trends in animation and visualization

1991 • 60 citations

Effects of cobalt on haem proteins of erythropoietin‐producing HepG2 cells in multicellular spheroid culture

1994 • 38 citations

Effects of Cadmium on Electrolyte Ions in Cultured Rat Hepatocytes Studied by X-Ray Microanalysis of Cryosections

1997 • 37 citations

Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys

1991 • 31 citations

Changes in redox affect the activity of erythropoietin RNA binding protein

1995 • 31 citations

Cell-specificity and signaling pathway of endothelin-1 gene regulation by hypoxia

1995 • 19 citations

In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction

1993 • 13 citations

Evidence for a relationship between the generation of reactive intermediates and the physicochemical characteristics of nickel oxides

1996 • 10 citations